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| 1 | Multi-component AVO response of thin beds based on reflectance spectrum theory显示文摘地震 AVO 分析现在是为认出潜在的烃水库的主要标准之一。带 stratigraphic 结构,岩性学,和毛孔液体的信息的体积散布信息为地震探索是更有用的。然而,传统的 AVO 分析基于 Zoeppritz 方程,它仅仅包含单个接口的信息。薄床厚度的量的解释对薄床结构解释,水库描述,和侧面的水库预言必要。基于在频率的有弹性的波浪繁殖矩阵,域在这篇论文导出的反射光谱方程证明接口和间隔在振幅上有效果。方程关于单个接口并且体积散布包括信息。因为反射光谱方程是薄床厚度和频率的连续功能,在反射光谱上分析单个频率和床厚度的效果是方便的。床厚度是可被分析的直到床厚度是 vanishingly 小的。这些特征不能被 Fourier 变换完成。震波的繁殖是复杂的,各种各样的波浪模式同时存在。反射光谱包括各种各样的宣传波浪模式和 multiples 并且对模仿多部件更好薄床 AVO 回答比跟踪方法的光线。 | Chen Tiansheng Liu Yang | 2006 | Applied Geophysics2006，3，1： | 7 |
| 2 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77hkxfufcovfou06kbq.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 3 | Effect of preparation methods on the structure and catalytic performance of Fe–Zn/K catalysts for CO2 hydrogenation to light olefins显示文摘Potassium promoted iron–zinc catalysts prepared by co-precipitation method(C–Fe–Zn/K),solvothermal method(S–Fe–Zn/K)and hydrothermal method(H–Fe–Zn/K)could selectively convert CO_2to light olefins,respectively.The physicochemical properties of the obtained catalysts were determined by SEM,N_2physisorption,XRD,H_2-TPR,CO_2-TPD and XPS measurements.The results demonstrated that preparation methods had great influences on the morphology,phase structures,reduction and adsorption behavior,and hence the catalytic performance of the catalysts.The samples prepared by hydrothermal and co-precipitation method generated small uniform particles and led to lower specific surface area.In contrast,microspheres with larger specific surface area were formed by self-assembly of nanosheets using solvothermal method.ZnFe_2O_4was the only detectable phase in the fresh C–2Fe–1Zn/K,S–3Fe–1Zn/K and S–2Fe–1Zn/K samples.ZnFe_2O_4and ZnO co-existed with increasing Zncontent in S–1Fe–1Zn/K sample,while ZnO and Fe_2O_3could be observed over H–2Fe–1Zn/K sample.All the used samples contained Fe_3O_4,ZnO and Fe_5C_2.The peak intensity of ZnO was strong in the AR-H–2Fe–1Zn/K sample while it was the lowest in the AR-C–2Fe–1Zn/K sample after reaction.The formation of ZnFe_2O_4increased the interaction between iron and zinc for C–2Fe–1Zn/K and S–Fe–Zn/K samples,causing easier reduction of Fe_2O_3to Fe_3O_4.The surface basicity of the sample prepared by co-precipitation method was much more than that of the other two methods.During CO_2hydrogenation,all the catalysts showed good activity and olefin selectivity.The CO selectivity was increased with increasing Zncontent over S–Fe–Zn/K samples.H–2Fe–1Zn/K catalyst preferred to the production of C_5^+hydrocarbons.CO_2conversion of 54.76%and C_2~=–C_4~=contents of 57.38%were obtained on C–2Fe–1Zn/K sample,respectively. | Xu Wang Jianli Zhang Jingyu Chen Qingxiang Ma Subing Fan Tiansheng Zhao | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 6 |
| 4 | Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning显示文摘Previous studies have demonstrated that pine pollen can inhibit cerebral cortical cell apoptosis in mice with arsenic poisoning.The present study sought to detect the influence of pine pollen on apoptosis-related proteins.Immunohistochemistry,western blotting and enzyme-linked immunosorbent assays were used to measure the levels of apoptosis-related proteins in the cerebral cortex of mice with arsenic poisoning.Results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing Bax,Bcl-2 protein expression and increasing p53 protein expression. | Yanhong Luo Yaodong Wei Taizhong Wang Dongzhu Chen Tiansheng Lu Ruibo Wu Keke Si | 2012 | Neural Regeneration Research2012，7，12： | 4 |
| 5 | Joint PP and PS AVO inversion based on Zoeppritz equations显示文摘Considering Zoeppritz equations,reflections of PP and PS are only the function of ratios of density and velocity.So the inversion results will be the same if the ratios are the same but values of density,velocities of P-wave and S-wave are different without strict constraint.This paper makes efforts to explore nonlinear simultaneous PP and PS inversion with expectation to reduce the ambiguity of AVO analysis by utilizing the redundancy of multi-component AVO measurements.Accurate estimation of ratio parameters depends on independence of input data.There are only two independent AVO attributes for PP reflectivity (i.e.intercept and gradient) and two for PS reflectivity (i.e.pseudo-intercept and pseudo-gradient or extreme amplitude),respectively.For individual PP and PS inversion,the values of least-squares objective function do not converge around a large neighborhood of chosen true model parameters.Fortunately for joint PP and PS inversion the values of the least-squares objective function show closed contours with single minima.Finally the power function fitting is used to provide a higher precision AVO attributes than traditional polynomial fitting.By using the four independent fitting attributes (two independent attributes for PP and PS respectively),the inversion of four ratio parameters (velocities and densities) would be estimated with less errors than that in traditional method. | Xiucheng Wei Tiansheng Chen | 2011 | Earthquake Science2011，24，4： | 2 |
| 6 | Regulating the nanoscale intimacy of metal and acidic sites in Ru/γ-Al_(2)O_(3)for the selective conversions of lignin-derived phenols to jet fuels显示文摘Catalytic hydrodeoxygenation(HDO)of biomass-derived oxy-compounds to advanced hydrocarbon fuels usually requires bifunctional catalysts containing metals and acidic sites.The appropriate tuning of metal and/or acidic active sites at interfaces of bifunctional catalysts can significantly improve catalyst activity and product selectivity.Here,4-trifuoromethyl salicylic acid(TFMSA),as a hydrothermal stable organic acid,was employed to tailor the bifunctional interface of Ru/γ-Al_(2)O_(3)to enhance the catalytic performance on converting lignin-derived phenols to jet fuel range cycloalkanes.More than 80%phenol was converted into cyclohexane at 230°C for 1 h over Ru/γ-Al_(2)O_(3)modified by TFMSA,which was about three times higher than that over unmodified Ru/γ-Al_(2)O_(3).X-ray diffraction(XRD),Transmission electron microscope(TEM),H2 chemisorption,and energy dispersive X-ray spectroscopy(EDS)elemental mapping results indicated that Ru nanoparticles and TFMSA were well distributed onγ-Al_(2)O_(3),and a nanoscale intimacy between Ru and TFMSA was reached.Meanwhile,Fourier transform infrared spectroscopy after pyridine adsorption(Py-FT-IR)analysis proved that Brønsted acidic sites on the catalytic interfaces of TFMSA modified Ru/γ-Al_(2)O_(3)had been improved.Moreover,the kinetic and density functional theory(DFT)results suggested that the synergistic effects of adjacent Ru nanoparticles and acidic sites were crutial for promoting the rate-limiting conversion step of phenol HDO to cyclohexane. | Shanshuai Chen Weichen Wang Xue Li Puxiang Yan Wanying Han Tian Sheng Tiansheng Deng Wanbin Zhu Hongliang Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 7 | Reservoir prediction using multi-wave seismic attributes显示文摘The main problems in seismic attribute technology are the redundancy of data and the uncertainty of attributes,and these problems become much more serious in multi-wave seismic exploration.Data redundancy will increase the burden on interpreters,occupy large computer memory,take much more computing time,conceal the effective information,and especially cause the 'curse of dimension'.Uncertainty of attributes will reduce the accuracy of rebuilding the relationship between attributes and geological significance.In order to solve these problems,we study methods of principal component analysis (PCA),independent component analysis (ICA) for attribute optimization and support vector machine (SVM) for reservoir prediction.We propose a flow chart of multi-wave seismic attribute process and further apply it to multi-wave seismic reservoir prediction.The processing results of real seismic data demonstrate that reservoir prediction based on combination of PP-and PS-wave attributes,compared with that based on traditional PP-wave attributes,can improve the prediction accuracy. | Ye Yuan Yang Liu Jingyu Zhang Xiucheng Wei Tiansheng Chen | 2011 | Earthquake Science2011，24，4： | 1 |
| 8 | Iron/copper promoted oxidative homo - coupling reaction of terminal alkynes using air as the oxi- dam显示文摘 | Xu Meng Chuanbin Li Baochun Han Tiansheng Wang Baohua Chen | 2010 | Tetrahedron2010，66，23： | 1 |
| 9 | Efficient gene editing in a medaka(Oryzias latipes)cell line and embryos by SpCas9/tRNA-gRNA显示文摘Generation of mutants with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)is commonly carried out in fish species by co-injecting a mixture of Cas9 messenger RNA(mRNA)or protein and transcribed guide RNA(gRNA).However,the appropriate expression system to produce functional gRNAs in fish embryos and cells is rarely present.In this study,we employed a poly-transfer RNA(tRNA)-gRNA(PTG)system driven by cytomegalovirus(CMV)promoter to target the medaka(Oryzias latipes)endogenous gene tyrosinase(tyr)or paired box 6.1(pax6.1)and illustrated its function in a medaka cell line and embryos.The PTG system was combined with the CRISPR/Cas9 system under high levels of promoter to successfully induce gene editing in medaka.This is a valuable step forward in potential application of the CRISPR/Cas9 system in medaka and other teleosts. | Qihua PAN Junzhi LUO Yuewen JIANG Zhi WANG Ke LU Tiansheng CHEN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 0 |
| 10 | Filamentation initiated by Cas2 and its association with the acquisition process in cells显示文摘Cas1-and-Cas2-mediated new spacer acquisition is an essential process for bacterial adaptive immunity.The process is critical for the ecology of the oral microflora and oral health.Although molecular mechanisms for spacer acquisition are known,it has never been established if this process is associated with the morphological changes of bacteria.In this study,we demonstrated a novel Cas2-induced filamentation phenotype in E.coli that was regulated by co-expression of the Cas1 protein.A 30 amino acid motif at the carboxyl terminus of Cas2 is necessary for this function.By imaging analysis,we provided evidence to argue that Cas-induced filamentation is a step coupled with new spacer acquisition during which filaments are characterised by polyploidy with asymmetric cell division.This work may open new opportunities to investigate the adaptive immune response and microbial balance for oral health. | Lei Wang Xin Yu Mengjie Li Guiqin Sun Lin Zou Tiansheng Li Linlin Hou Yameng Guo Danfeng Shen Di Qu Xunjia Cheng Li Chen | 2019 | International Journal of Oral Science2019，11，4： | 0 |
| 11 | Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target显示文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3]. | Yingkuan Shao Kailun Xu Xi Zheng Biting Zhou Xiuli Zhang Lin Wang Yaoting Sun Dan Li Ting Chen Jian Wang Shaojun Yu Lifeng Sun Xiaoming Xu Shaozhi Dai Huanhuan Gao Guan Ruan Wei Liu Xue Cai Tiansheng Zhu Lina Qi Jiani Chen Wangxiong Hu Xingyue Weng Yi Zhu Xueping Xiang Zhiyuan Hu Jinfan Li Lirong Chen Jimin Shao Shu Zheng Tiannan Guo | 2022 | Cancer Communications2022，42，2： | 0 |
| 12 | Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives显示文摘Tissue engineering aims to offer large-scale replacement of damaged organs using implants with the com-bination of cells,growth factors and scaffolds.However,the intra/peri-implant region is exposed to se-vere hypoxic stress and oxidative stress during the early stage of implantation with bone graft materials,which endangers the survival,proliferation and differentiation of seed cells within the implants as well as the host cells surrounding the implants.If the bone graft material could spontaneously and intelligently regulate the hypoxic stress and oxidative stress to a moderate level,it will facilitate the vascularization of the implants and the rapid regeneration of the bone tissue.In this review,we will first introduce the signaling pathways of cellular response under hypoxic stress and oxidative stress,then present the clas-sical material designs and examples in response to hypoxic stress and oxidative stress.And finally,we will address the important role of epigenetic mechanisms in the regulation of hypoxic stress and oxida-tive stress and describe the potential applications and prospective smart bone graft materials based on novel epigenetic factors against hypoxic stress and oxidative stress in bone repair.The main content of this review is summarized in the following graphical abstract. | Hao Hu Xiao Liu Jun Chen Shangbin Cui Hualin Yi Gang Wang Renxian Wang Tiansheng Zheng Ben Wan Zhiyu Zhou Yong Wan Manman Gao Dafu Chen Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 13 | Biomimetic hydroxyapatite coating on the 3D-printed bioactive porous composite ceramic scaffolds promoted osteogenic differentiation via PI3K/AKT/mTOR signaling pathways and facilitated bone regeneration in vivo显示文摘The architecture and surface modifications have been regarded as effective methods to enhance the bi-ological response of biomaterials in bone tissue engineering.The porous architecture of the implanta-tion was essential conditions for bone regeneration.Meanwhile,the design of biomimetic hydroxyap-atite(HAp)coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate osteogenesis.However,bioactive bio-ceramics such asβ-tricalcium phosphate(β-TCP)and calcium sili-cate(CS)with superior apatite-forming ability were reported to present better osteogenic activity than that of HAp.Hence in this study,3D-printed interconnected porous bioactive ceramicsβ-TCP/CS scaf-fold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction,and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells(mBM-SCs)and the potential mechanisms were explored.The results indicated that HAp apatite coating en-hanced cell proliferation,alkaline phosphatase(ALP)activity,and osteogenic gene expression.Further-more,PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular functions.The present results demonstrated that the key molecules of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and mammalian target of rapamycin(mTOR)were activated after the biomimetic hydrox-yapatite coating were constructed on the 3D-printed ceramic scaffolds.Besides,the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor HY-10358.In vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone quality.These results suggest that biomimetic HAp coating constructed on the 3D-printed bioac-tive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration. | Bizhi Tan Naru Zhao Wei Guo Fangli Huang Hao Hu Yan Chen Jungang Li Zemin Ling Zhiyuan Zou Rongcheng Hu Chun Liu Tiansheng Zheng Gang Wang Xiao Liu Yingjun Wang Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 14 | Atomically precise gold nanoclusters for healthcare applications显示文摘The potential application of gold nanoparticles(GNPs)in biomedicine has been extensively reported.However,there is still too much puzzle about their real face and potential health risks in comparison with the commercial drug molecules.The emergence of atomically precise gold nanoclusters(APGNCs)provides the opportunity to address the puzzle due to their ultrasmall size,defined molecular formula,editable surface engineering,available structures and unique physicochemical properties including excellent biocompatibility,strong luminescence,enzyme-like activity and efficient renal clearance,et al.Recently,these advantages of APGNCs also endow them promising performances in healthcare such as bioimaging,drug delivery,antibacterial and cancer therapy.Especially,their clear composition and structures like the commercial drug molecules facilitate the study of their functions and the structure-activity relationship in healthcare,which is essential for the guided design of APGNC nanomedicine.Therefore,this review will focus the advantages and recent progress of APGNCs in health care and envision their prospects for the future. | Tiansheng Wei Congcong Mi Yan Sun Yining Chen Xiaoyang Hu Zibao Gan Xiuwen Zheng | 2023 | Biomedical Engineering Communications2023，2，4： | 0 |
| 15 | Twin Domain Fragmentation in YBa_(2)Cu_(3)O_(7-δ) Under Electron Irradiation显示文摘Detwinning and retwinnuig processes in the orthorhombic YBa_(2)Cu_(3)O_(7-δ) have been directly observed under appropriate electron irradiation by transmission electron microscope.These processes can be repeated many times and are accompanied by twin domsdn fragmentation and appreciable increase of twin interface density which is a potential pinning center in YBa_(2)Cu_(3)O_(7-δ),The meaning of this effect in raising J_(c) of the material YBa_(2)Cu_(3)O_(7-δ) is suggested and discussed. | SHI Tiansheng WANG Geya ZHU Jie CHEN Yixing ZHANG Jihua | 1991 | Chinese Physics Letters1991，8，10： | 0 |
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