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| 1 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Primary liposarcoma of esophagus:A case report显示文摘当食道的脂肪的肉瘤是一个极其稀罕的肿瘤时,脂肉瘤是在成年生命的最普通的软织物肉瘤。在世界文学,仅仅食道的脂肪的肉瘤的 14 个案例被描述了。我们报导着急地与一枚燃烧制动火箭为剧烈腹上部的疼痛进入我们的医院的一个 72 年的老男病人胸骨的感觉,坚持的恶心,呕吐并且咽下困难。钡燕子,上面胃肠(官方补给) 内视镜检查法,食道的测压法和 CT 扫描,没能精确地诊断损害。在一个食道的息肉样瘤的外科的切除术以后,组织学的考试揭示了一个区分得好的等级我脂肪的肉瘤。诊断、治疗学的工具被讨论,文学的结果被考察。 | Theodore D Liakakos Theodore G Troupis Charalambos Tzathas Konstantina Spirou Irene Nikolaou Spiridon Ladas Gabriel M Karatzas | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 4 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 5 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 6 | Reducing Hospital Morbidity and Mortality Following Esophagectomy显示文摘 | B.Zane Atkins Ashish S. Shah Kelley A. Hutcheson Jennifer H. Mangum Theodore N. Pappas David H. Harpole Thomas A. D’Amico | 2004 | The Annals of Thoracic Surgery2004，，4： | 2 |
| 7 | principles of stressfracture management : the ways and bows of an increasingly common injury显示文摘 | Andrew D William J Theodore A | 2001 | Postgrad Med2001，110，3： | 1 |
| 8 | CV706,a prostate cancer-specific adenovirus variant,in combination with radiotherapy produces synergistic antitumor efficacy without increasing toxicity显示文摘 | Yu C Theodore D Jeanette D | 2001 | Cancer Res2001，61，14： | 1 |
| 9 | An inmging overview of pri- mary tumors of the spine part-Malignant tumors 显示文摘 | Theodorou D Theodorou S Sartoris D | 2008 | Clin hnaging2008，32，3： | 1 |
| 10 | Magnetically pro- cessedcarbon nanotube/epoxy nanocomposites: Morpholo- gy, thermal, and mechanical properties显示文摘 | Abdalla M Dean D Theodore M | 2010 | Polymer2010，51，7： | 1 |
| 11 | The ability of traditional vital signs and shock in- dex to identify ruptured ectopic pregnancy显示文摘 | ROBERT H BIRRHAHN M D THEODORE J | | Am J obstet Gyneeol0，189，： | 1 |
| 12 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 13 | Management options in vertebral artery injuries显示文摘 | Demetriades D Theodorou D Asensio J | 1996 | Br J Surg1996，83，： | 1 |
| 14 | Social stigmatization and hepatitis C virus infection显示文摘 | Zacks S Beavers K Theodore D | 2006 | Journal of Clinical Gastroenterology2006，40，3： | 1 |
| 15 | The degree of oxidative stress is associated with major adverse effects after lung resection:a prospective study显示文摘 | Misthos P Katsaragakis S Theodorou D | | 0，，04： | 1 |
| 16 | The degree of oxidative stress is associated with major adverse dffects after lung resection:aprospective study显示文摘 | Misthos P Katsaragakis S Theodorou D | 2006 | Eur J Cardiothorac Surg2006，29，4： | 1 |
| 17 | Manufactured nanoparticles:their uptake and effects on fish-a mechanistic analysis 显示文摘 | Richard D Handy Theodore B Henry Tessa M | 2008 | Ecotoxicology2008，17，： | 1 |
| 18 | Detailed molecular structure of a vinyl polymer glass 显示文摘 | THEODOROU D N SUTER U W | 1985 | Macromolecules1985，18，7： | 1 |
| 19 | Adverse effects associated with physical restraint 显示文摘 | Wanda K Mohr Theodore A Petti Brian D Mohr | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 20 | Thyrotoxic periodic paraly-sis and intravenous propranolol in the emergency setting显示文摘 | Robet H Birkhahn M D Theodore J | 2000 | J Emerg Medic2000，，： | 1 |
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