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| 1 | Locomotor activity and anxiety status, but not spatial working memory,are affected in mice after brief exposure to cuprizone显示文摘Chronic long-term exposure to cuprizone causes severe brain demyelination in mice,which leads to changes in locomotion,working memory and anxiety.These findings suggest the importance of intact myelin for these behaviors.This study aimed to investigate the possible behavioral changes in mice with mild oligodendrocyte/myelin damage that parallels the white matter changes seen in the brains of patients with psychiatric disporders.We used the cuprizonetreated mouse model to test both tissue changes and behavioral functions(locomotor activity,anxiety status,and spatial working memory).The results showed that mice given cuprizone in their diet for 7 days had no significant myelin breakdown as evaluated by immunohistochemical staining for myelin basic protein,while the number of mature oligodendrocytes was reduced.The number and length of Caspr protein clusters,a structural marker of the node of Ranvier,did not change.The locomotor activity of the cuprizonetreated mice increased whereas their anxiety levels were lower than in normal controls;spatial working memory,however,did not change.These results,for the first time,link emotion-related behavior with mild white matter damage in cuprizone-treated mice. | Handi Zhang Yanbo Zhang Haiyun Xu Lingyan Wang Jinsong Zhao Junhui Wang Zhijun Zhang Qingrong Tan Jiming Kong Qingjun Huang Xin-Min Li | 2013 | Neuroscience Bulletin2013，29，5： | 4 |
| 2 | Stress Proteins (HSPs): Method of Detection and Their use as an Environmental Biomarker显示文摘 | Lewis S Handy R D | 1999 | Ecotoxicology1999，8，： | 2 |
| 3 | Growth and optical properties of ytterbium and rare earth ions codoped CaF2-SrF2 eutectic solid-solution(RE=Y^(3+),Gd^(3+),La^(3+))显示文摘Ytterbium and rare earth ions(RE=Y,Gd,La)codoped CaF_(2)-SrF_(2)single crystals(3 at%Yb,6 at%RE:CaF_(2)-SrF_(2))were fabricated by temperature gradient technology(TGT).All the space groups remain the same Fm3m as that of Yb:CaF_(2)-SrF_(2).The lattice parameter a,unit cell volume V,as well as bond length of Ca/Sr-F and F-F increase in the sequence of rare-earth ions radius Y^(3+) | Binbin Jiang Lihe Zheng Dapeng Jiang Handi Yin Jiangang Zheng Qiuhong Yang Guofeng Cheng Liangbi Su | 2021 | Journal of Rare Earths2021，39，4： | 2 |
| 4 | Microfluidic-based single cell trapping using a combination of stagnation point flow and physical barrier显示文摘Single cell trapping in vitro by microfluidic device is an emerging approach for the study of the relationship between single cells and their dynamic biochemical microenvironments. In this paper, a hydrodynamic-based microfluidic device for single cell trapping is designed using a combination of stagnation point flow and physical barrier.The microfluidic device overcomes the weakness of the traditional ones, which have been only based upon either stagnation point flows or physical barriers, and can conveniently load dynamic biochemical signals to the trapped cell. In addition, it can connect with a programmable syringe pump and a microscope to constitute an integrated experimental system.It is experimentally verified that the microfluidic system can trap single cells in vitro even under flow disturbance and conveniently load biochemical signals to the trapped cell. The designed micro-device would provide a simple yet effective experimental platform for further study of the interactions between single cells and their microenvironments. | Miao Yu Zongzheng Chen Cheng Xiang Bo Liu Handi Xie Kairong Qin | 2016 | Acta Mechanica Sinica2016，32，3： | 2 |
| 5 | A Laboratory Study of Oil Recovery by SolutionGas Drive显示文摘 | | 1958 | Transaction AIME1958，213，： | 1 |
| 6 | Trust and the Virtual Organization 显示文摘 | Handy C | 1995 | Harvard Business Review1995，，3： | 1 |
| 7 | Stress Proteins (HSPs):Method of detection and their use as an environmental biomarker 显示文摘 | Lewis S Handy R D | 1999 | Ecotoxicology1999，8，： | 1 |
| 8 | Epigenetic modifications: basic mechanisms and role in cardiovascular disease 显示文摘 | Handy DE Castro R Loscalzo J | 2011 | Circulation2011，123，19： | 1 |
| 9 | Assessing Economic preferences forbiologica! diversity and ecosystem services at the Central Sulawesi Rainforest Margin 显示文摘 | Jan Barkmann Klaus Glenk Handian Handi | 2007 | Environmental Science and Engineering2007，，10： | 1 |
| 10 | Reconstruction of the anterior cruciate ligament:dynamic strain evaluation of the graft显示文摘 | HANDI M DRZIK M CERULLI G | | 0，，03： | 1 |
| 11 | Ecotoxicity test methods for engineered nanomaterials: practicalexperiences and recommendations from the bench显示文摘 | Handy RD Cornelis G Fernandes T | 2012 | Environ Toxicol Chem2012，31，1： | 1 |
| 12 | The Arch in Soil Arching显示文摘 | Handy B L | 1985 | Journal of Geotechnical Engineering1985，111，3： | 1 |
| 13 | Adiponectin inhibits leptinsignalling via multiple mechanisms to exert protective effects againsthepatic fibrosis显示文摘 | HANDY JA FU PP KUMAR P | 2011 | Biochem J2011，440，3： | 1 |
| 14 | Miller MD The graft tunnel angles in posterior eruciate ligament reconstruction: acadaveric comparison of two techniques for femoral tunnel placement显示文摘 | Handy MH Blessey PB Kline AJ | 2005 | Arthroscopy2005，21，： | 1 |
| 15 | Infrastructure, programs, and policies to increase bicycling: An international review 显示文摘 | PUCHER J DILL J HANDY S | 2010 | Preventive Medicine2010，50，： | 1 |
| 16 | Regional Versus Local Accessibility: Neo-traditional Development and Its Implications for Non-work Travel显示文摘 | Handy S L | 1992 | Built Environment1992，18，4： | 1 |
| 17 | Measuring the Unmeasurable: Urban Design Qualities Related to WaIKability显示文摘 | Ewing R Handy S | 2009 | Journal of Urban Design2009，，1： | 1 |
| 18 | Trust and the Virtual Organization 显示文摘 | Handy C | 1995 | Harvard Business Review1995，，73： | 1 |
| 19 | Toxic Microcystis is widespread in Lake Erie: PCR detection of toxin genes and molecular characterization of associated cyanobacterial communities 显示文摘 | Ouellette A J A Handy S M Wilhelm S W | 2006 | Microbial Ecology2006，51，： | 1 |
| 20 | A laboratory study of oil recovery by solution gas drive显示文摘 | HANDY L | 1958 | Transaction AIME1958，212，： | 1 |
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