|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 2 | Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models显示文摘AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein isothiocyanate(FITC)-dextran was measured to assess permeability across cell monolayers and rat colon tissues. Effects of plecanatide and dolcanatide on the integrity of tight junctions in Caco-2 and T84 monolayers and on the expression and localization of occludin and zonula occludens-1(ZO-1) were examined by immunofluorescence microscopy. Anti-nociceptive activity of these agonists was evaluated in trinitrobenzene sulfonic acid(TNBS)-induced inflammatory as well as in non-inflammatory partial restraint stress(PRS) rat models. Statistical significance between the treatment groups in the permeability studies were evaluated using unpaired t-tests.RESULTS Treatment of T84 and Caco-2 monolayers with lipopolysaccharide(LPS) rapidly increased permeability, which was effectively suppressed when monolayers were also treated with plecanatide or dolcanatide. Similarly, when T84 and Caco-2 monolayers were treated with LPS, cell surface localization of tight junction proteins occludin and ZO-1 was severely disrupted. When cell monolayers were treated with LPS in the presence of plecanatide or dolcanatide, occludin and ZO-1 were localized at the cell surface of adjoining cells, similar to that observed for vehicle treated cells. Treatment of cell monolayers with plecanatide or dolcanatide without LPS did not alter permeability, integrity of tight junctions and cell surface localization of either of the tight junction proteins. In rat visceral hypersensitivity models, both agonists suppressed the TNBS-induced increase in abdominal contractions in response to colorectal distension without affecting the colonic wall elasticity, and both agonists also reduced colonic hypersensitivity in the PRS model. CONCLUSION Our results suggest that activation of GC-C signaling might be involved in maintenance of barrier function, possibly through regulating normal localization of tight junction proteins. Consistent with these findings, plecanatide and dolcanatide showed potent antinociceptive activity in rat visceral hypersensitivity models. These results imply that activation of GC-C signaling may be an attractive therapeutic approach to treat functional constipation disorders and inflammatory gastrointestinal conditions. | Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 3 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 4 | The relations among environmental disclosure, environmental performance, and economic performance: a simultaneous equations approach显示文摘 | Sulaiman A Al-Tuwaijri Theodore E Christensen K.E Hughes | 2003 | Accounting, Organizations and Society2003，，5： | 2 |
| 5 | Adaptive design optimization of wireless sensor networks using genetic algorithms显示文摘 | Konstantinos P F Theodore A T | 2007 | Computer Networks2007，51，4： | 1 |
| 6 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | LOWE S E THEODOROU M K TRINCI A P J | 1985 | Journal of General Microbiology1985，131，： | 1 |
| 7 | principles of stressfracture management : the ways and bows of an increasingly common injury显示文摘 | Andrew D William J Theodore A | 2001 | Postgrad Med2001，110，3： | 1 |
| 8 | Chaoslike states can be expected before andafter logistic growth 显示文摘 | THEODORE M DEBECKER A | 1992 | Technological forecasting & so- cial change1992，41，2： | 1 |
| 9 | Image quality of sparse -aperture designs for remote sensing显示文摘 | Robert D F Theodore A T Jason R C | 2002 | Optical Engineering2002，41，8： | 1 |
| 10 | Hepatitis B virus reactivation in patients receivingchemotherapy for malignancies:role of precore stop-codon and basic core promoter mutations显示文摘 | Alexopoulou A Theodorou M Dourakis SP | 2006 | J Viral Hepat2006，13，9： | 1 |
| 11 | Amplification of avian reovirus RNA using the reverse transcriptase-polymerase chain reaction显示文摘 | Xie Zhixun Avian A F Theodore G | 1997 | Avian Dis1997，41，： | 1 |
| 12 | Trends in Prevalence, Awareness, Treatment, and Control of Hypertension the United States, 1988-2000显示文摘 | Hajjar Ihab Kotchen Theodore A | 2003 | The Journal of the American Medical Association2003，290，： | 1 |
| 13 | Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1α, 25-dihydroxyvitamin D3-assoeiated IEX-1 gene repression显示文摘 | Im J H Craig Theodore A Pittelkow M R Rajiv Kumar | 2002 | Oncogene2002，21，： | 1 |
| 14 | Development of glucocorticoid receptor regulation in the rat forebrain: Implications for adverse effects of glucocorticoids in preterm infants显示文摘 | Theodore A | 2008 | Brain Research Bulletin2008，78，： | 1 |
| 15 | Comparison of the assumed modes and finite element modes for flexible multilink manipulators显示文摘 | Theodore R J Ghosal A | 1995 | International Journal of Robotics Research1995，14，2： | 1 |
| 16 | AudiomagnetoteUuric characterization of range-front faults, Snake Range, Nevada显示文摘 | THEODORE H A DONALD S S | 2011 | Geophysics2011，76，1： | 1 |
| 17 | Level-of-service model for pedestrians at signalized intersections显示文摘 | Theodore A Petritsch Bruce W Landis Peyton S McLeod | 2005 | Journal of Transportation Research Board2005，，1： | 1 |
| 18 | Adverse effects associated with physical restraint 显示文摘 | Wanda K Mohr Theodore A Petti Brian D Mohr | 2003 | Can J Psychiatry2003，48，5： | 1 |
| 19 | Towards a non-invasive interictal application of hypothermia for treating seizures:a feasibility and pilot study显示文摘 | Bagic A Theodore WH Boudreau EA | 2008 | Acta Neurol Seand2008，118，： | 1 |
| 20 | Detection of Avian Adenovirus by Polymerase Chain Reaction 显示文摘 | Xie Z X Fadl A A Theodore G | 1999 | Avian Deseases1999，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员