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| 1 | Antibacterial and Antibiotic-Potentiation Activities of Some Cameroonian Food Plants against Multi-Drug Resistant Gram-Negative Bacteria显示文摘Objective:To evaluate the in vitro antibacterial properties and the ability to potentiate some common antibiotics effects of the methanol extracts of 11 Cameroonian food plants on 29 Gram-negative bacteria expressing multidrug resistant(MDR) phenotypes.Methods:The antimicrobial activity of the extracts was performed using the broth microdilution method.The phytochemical screening of these extracts was also performed using standard methods.Resutts:Ocimum basilicum,Gnetum africanum and Eucalyptus robusta extracts possessed an antibacterial activity against all the 29 studied bacteria.The extracts from G.africanum and E.robusta were the most active with the lowest minimal inhibitory concentration of 64 μg/mL on Escherichia coli AG100 A for both extracts and also against Klebsiella pneumoniae K24 for G.africanum.When tested in the presence of phenylalanine-arginine β-Naphtylamide(PA β N),an efflux pump inhibitor,the extract of Thymus vulgaris and E.Robusta showed the best activities on most tested strains.E.Robusta extract showed good synergistic effects,improving the activity of commonly used antibiotics in about 85%of cases.Conclusion:The overall results obtained provide the baseline information for the use of the tested plants in the treatment of bacterial infections. | Simplice B.Tankeo Stephen T.Lacmata Jaures A.K.Noumedem Jean P.Dzoyem Jules R Kuiate Victor Kuete | 2014 | Chinese Journal of Integrative Medicine2014，20，7： | 7 |
| 2 | E24 profile slope stability analysis in Haizhou Opencast Coal Mine of Fuxin显示文摘The E24 profile slope analyzed belongs to a series of excavated slopes of the Haizhou Opencast Coal Mine. It seems to be divided into Downslope Part and Upslope Part. Its profile comprises two noticeable coal seams, called the 8# and 9# weak layers, considered as the potential failure surfaces. In consideration of the actual configuration as in the perspective of any modification, assessing the stability of this slope with various profile forms under given conditions, and assessing the risk of instability and quantifying the influence of earthworks or other modifications to the stability of this slope, have constituted the primordial objectives carried out. From assumed potential failure surfaces, any specific profiles and specified slip surfaces are defined. A factor of safety (FoS) is computed for each specified slip surface; the smallest FoS found corresponds to the least favorable slip surface. The safety factor values obtained are compared to the suggested safety factor. Limit equilibrium methods of vertical slices implemented in Slope/W, computer program for slope stability analyses, have been adopted to perform the E24 slope stability analysis. The safety factor values computed with 9# weak layer are lower than for 8#; the factors of safety obtained with Sarma's method are the smallest; more, without groundwater (long term) overall values are greater than those determined under groundwater condition (short term). The lowest safety factor value is found for a profile depending on an adopted earthwork sequence. The E24 profile slope stability analysis shows the instability risk for the deepest weak layer, and also shows the short and long term stability of this slope for the envisaged earth movements. However it demonstrates the existence of instability risk for any earthwork firstly affecting the downslope part. | Simplice F. BOBY | 2007 | Global Geology2007，10，2： | 3 |
| 3 | Antimicrobial resistance of abnormal vaginal discharges microorganisms in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of bacterial strains and fungal strains infecting the vaginal tract and test their sensitivity to antibiotics in women attending Saint Camille Medical Centre in Ouagadougou.Methods:From January 2008 to December 2009,a total of 2000 vaginal swabs were cultivated for bacterial and fungal identification and isolation.Furthermore,bacterial strains were tested for their susceptibility to several antibiotics used in routine in the centre. Results:The results revealed that microbial isolation and identification was attempted for 1536/2000 sample,a positivity rate of 76.80%.Candida albicans(48.76%),followed by Escherichia coli(16.67%),Streptococcus agalactiae(8-14%) and Staphylococcus aureus(7.55%) were the major agents of genital tract infections in patients.Mycoplasma hominis and Ureaplasma urealyticum combined accounted for less than 7%.Trichomonas vaginalis was identified in 1.04%coses.The antimicrobial tests revealed that the microorganisms developed resistance to several antibiotics including beta lactams.However,antibiotics such as cefamenzol,ciprofloxacin and norfloxacin were still active on these bacteria.Conclusions:The results reveal that many sexually active women are infected by one or more microbial pathogens,probably because of the lock of hygiene or the adoption of some risky behaviors,such as not using condoms or having multiple sexual partners.Efforts should be made to address these points in the country. | Simplice D Karou Florencia Djigma Tani Sagna Christelle Nadembega Moctar Zeba Aboudoulaye Kabre Kokou Anani Djeneba Ouermi Charlemagne Gnoula Virginio Pietra Salvatore Pignatelli Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 4 | Catheter-based renal sympathetic denervation for resistant hypertension:durability of blood pressure reduction out to 24 months显示文摘 | Simplicity HTN-1 Investigators | 2011 | Hypertension2011，57，： | 1 |
| 5 | Seroepidemiology of Hepatitis B and C Viruses in the General Population of Burkina Faso显示文摘 | Issoufou Tao Tegwindé R. Compaoré Birama Diarra Florencia Djigma Theodora M. Zohoncon Maléki Assih Djeneba Ouermi Virginio Pietra Simplice D. Karou Jacques Simpore Annarosa Floreani | 2014 | Hepatitis Research and Treatment2014，，： | 1 |
| 6 | How Would Population Growth Affect Investment in the Future? Asymmetric Panel Causality Evidence for Africa显示文摘 | Simplice A. Asongu | 2013 | African Development Review2013，，1： | 1 |
| 7 | Study of Pineapple Peelings Processing into Vinegar by Biotechnology显示文摘 | Seyram K Sossou Yaovi Ameyapoh Simplice D Karou | 2009 | Pakistan Journal of Biological Sciences2009，12，11： | 1 |
| 8 | Size,efficiency,market power,and economies of scale in the African banking sector显示文摘There is a growing body of evidence that interest rate spreads in Africa are higher for big banks compared to small banks.One concern is that big banks might be using their market power to charge higher lending rates as they become larger,more efficient,and unchallenged.In contrast,several studies found that when bank size increases beyond certain thresholds,diseconomies of scale are introduced that lead to inefficiency.In that case,we also would expect to see widened interest margins.This study examines the connection between bank size and efficiency to understand whether that relationship is influenced by exploitation of market power or economies of scale.Using a panel of 162 African banks for 2001–2011,we analyzed the empirical data using instrumental variables and fixed effects regressions,with overlapping and non-overlapping thresholds for bank size.We found two key results.First,bank size increases bank interest rate margins with an inverted U-shaped nexus.Second,market power and economies of scale do not increase or decrease the interest rate margins significantly.The main policy implication is that interest rate margins cannot be elucidated by either market power or economies of scale.Other implications are discussed. | Simplice A.Asongu Nicholas M.Odhiambo | 2019 | Financial Innovation2019，5，1： | 1 |
| 9 | Interconnections between governance and socioeconomic conditions:Understanding the challenges in sub-Saharan Africa显示文摘Given that challenges on the issue of socioeconomic development faced by countries in sub-Saharan Africa(SSA)have been identified as critical to strengthening the inherent link between governance and socioeconomic conditions,this study examines the interconnections between governance and socioeconomic conditions in SSA.With a focus on 25 countries in SSA between 2005 and 2019,we conduct the analysis based on the Panel-Corrected Standard Error and System Generalized Method of Moments estimations and panel causality tests.The results show that SSA does not seem to have the means of effective governance to spur improved socioeconomic conditions.Moreover,the pervasiveness of institutional problems in many countries of SSA has been responsible for the poor socioeconomic conditions in the region.Likewise,governance quality and socioeconomic conditions are found to influence each other.An improvement in socioeconomic conditions could result in better governance quality.On the other hand,governance quality is viewed as a vital ingredient in achieving needed socioeconomic development outcomes.Thus,it is suggested that there is a need for countries in SSA to streamline governing systems toward engendering improved well-being.The introduction and implementation of transformative policies through effective governance are also necessary for ensuring critical structural changes and increasing social service provision.Overall,there should be a proactive identification of ineffective policies and procedures by policymakers to enhance meaningful impacts in the region. | Fisayo FAGBEMI Geraldine Ejiaka NZERIBE Tolulope Temilola OSINUBI Simplice ASONGU | 2021 | Regional Sustainability2021，2，4： | 1 |
| 10 | Part Ⅱ :Calculation of canopy photosynthesis显示文摘 | Spitters C J T Separating the diffuse and direct component of global radiation and its simplications for modeling canopy photosynthesis | 1986 | Agric For Meteorol1986，38，1： | 1 |
| 11 | In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants显示文摘Objective:To investigate the antimalarial effect of a few plants in Togo folk medicine. Methods:After ethnobotanical survey,Opilia celtidifolia,Pavetta corymbosa(P.corymbosa) and Tamarindus indica(T.indica) were selected for screening.In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi microtest.Results:Different IC50,values of the extracts ranged from 2.042 to 100.000μg/mL. According to the results,the methanol extract of aerial part of P.corymbosa followed by aqueous extract of fruit of T.indica were the most active(IC50 of 2.042 and 4.786μg/mL,respectively). Qualitative test revealed the presence of alkaloids in the leaves of P.corymbosa that may be responsible for the activity of the plant.Conclusions:Our study provides scientific evidence for usage of plant in the folk medicine,and further studies are needed for identification and purification of the active principles. | Koffi Koudouvo Simplice D.Karou Denise P.Ilboudo Kouami Kokou Kodjo Essien Kodjo Aklikokou Comlan de Souza Jacques Simpore Mensavi Gbeassor | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 1 |
| 12 | Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes显示文摘 | Stephen T. Lacmata Victor Kuete Jean P. Dzoyem Simplice B. Tankeo Gerald Ngo Teke Jules R. Kuiate Jean-Marie Pages Namrita Lall | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 13 | Catheter-based renal sympathet-ic denervation for resistant hypertension: durability of blood pres-sure reduction out to 24 months显示文摘 | Simplicity HTN-1 Investigators | 2011 | Hypertension2011，57，5： | 1 |
| 14 | Antimicrobial,antiplasmodial,haemolytic and antioxidant activities of crude extracts from three selected Togolese medicinal plants显示文摘Objective:To investigate the antioxidant,antimicrobial,antiplasmodial,acute toxicity and haemolytic activities of methanolic extracts of three plants.Phytochemical analysis to determine the phenolic contents was also carried out.Methods:The 2,2-diphenyl-1- picryl-hydrazyl(DPPH) free radical scavenging,NCCLS broth microdilution and Plasmodium Lactate Dehydrogenase(pLDH) assays were used to determine antioxidant,antimicrobial and antiplasmodial activities,respectively.Haemolysis assay was conducted on A+ human red blood cells and acute toxicity on male Swiss albino mice.Phenolics were quantitatively determined using spectrophotometric methods.Results:The DPPH assay yielded interesting antioxidant activities of methanolic extract of Parinari curatellifolia(P.curatellifolia) and Entada africana (E.africana)(IC50 were 0.20±0.01μg/mL and 0.47±0.01μg/mL,respectively).This activity was highly correlated with phenolic contents of extracts.The antimicrobial tests displayed minimal inhibitory concentrations(MICs) values ranging from 0.90 to 1.80 mg/mL for Serratia marcescens (5.marcescens) the most susceptible bacterial strain.MIC value was 1.20 mg/mL for susceptible fungal strains including Mucor rouxi(M.rouxi),Fusarium oxyporum(F.oxyporum) and Rhizopus nigricans(R.nigricans).pLDH assay showed moderate antiplasmodial activity of Balanites aegyptiaca(B.aegyptiaca)(IC50= 24.56±3.45μg/mL),however this extract was highly haemolytic and toxic in mice(LD50= 625±128mg/kg).Conclusions:Our results support in part the use of the selected plants in the treatment of microbial infections.In addition the plant showed interesting antioxidant activity that could be useful in the management of oxidative stress. | Simplice D Karou Tchadjobo Tchacondo Lassina Ouattara Kokou Anani Aly Savadogo Amegnona Agbonon Mossaclok Ben Attaia Comlan de Souza Mohsen Sakly Jacques Simpore | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 1 |
| 15 | Epidemiology and antibiotic resistance of bacterial meningitis in Dapaong,northern Togo显示文摘Objective:To assess the seasonality of the bacterial meningitis and the antibiotic resistance of incriminated bacteria over the last three years in the northern Togo.Methods:From January 2007 to January 2010,533 cerebrospinal fluids(CSF) samples were collected from patients suspected of meningitis in the Regional Hospital of Dapaong(northern Togo).After microscopic examination,samples were cultured for bacterial identification and antibiotic susceptibility. Results:The study included 533 patients(306 male and 227 female) aged from 1 day to 55 years [average age(13.00±2.07) years].Bacterial isolation and identification were attempted for 254/533 (47.65%) samples.The bacteria]species identified were:Neisseria meningitidis A(N.meningitidis A)(58.27%),Neisseria meningitidis W135(N,meningitidis W135)(7.09%),Streptococcus pneumoniae(S.pneumoniae)(26.77%),Haemophilus influenza B(H.influenza B)(6.30%) and Enterobacteriaceae(1.57%).The results indicated that bacterial meningitis occur from November to May with a peak in February for H.influenzae and S.pneumoniae and March for Neisseriaceae. The distribution of positive CSF with regards to the age showed that subjects between 6 and 12 years followed by subjects of 0 to 5 years were most affected with respective frequencies of 67.82%and 56.52%(P<0.001).Susceptibility tests revealed that bacteria have developed resistance to several antibiotics including aminosides(resistance rate>20%for both bacterial strains),macrolides(resistance rate>30%for H.influenzae) quinolones(resistance rate>15% for H.influenzae and N.meningitidis W135).Over three years,the prevalence of S.pneumoniae significantly increased from 8.48%to 73.33%(P<0.001),while the changes in the prevalence of H.influenzae B were not statistically significant:4.24%,vs.8.89%,(P= 0.233).Conclusions: Our results indicate that data in African countries differ depending on geographical location in relation to the African meningitis belt.This underlines the importance of epidemiological surveillance of bacterial meningitis. | Simplice D Karou Abago Balaka Mitiname Bamok Damhan Tchelougou Malki Assih Kokou Anani Kodjo Agbonoko Jacques Simpore Comlan de Souza | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，11： | 1 |
| 16 | Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial):a randomised controlled trial显示文摘 | Simplicity HTN-2 Investigators Esler MD Krum H | | 0，，9756： | 1 |
| 17 | Enteric parasites prevalence at Saint Camille Medical Centre in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of parasitic infections among patients attending Saint Camille Medical Centre and to estimate co-parasitic infections rates.Methods:From January to December 2009,stool samples were collected from 11 728 persons,aged from five months to 72 years and suffering from gastroenteritis.After macroscopic description,the stools were examined by light microscopy to search for the presence of parasites.Results:From the 11 728 analyzed stools,6 154(52.47%) were infected with at least one parasite.Protozoan frequently encountered were:Giardia intestinalis(43.47%),Entamoeba histolytica/Entamoeba dispar(30.74%) and Trichomonas irUestinalis(21.72%),while Hymenolepis nana(2.25%) was the most common helminth.Co-infections occurred in 22.34%cases.Within the multi-infected samples,dual and triple infections accounted for 71.18%and 20.00%,respectively.Giardia irUestinalis for protozoan and Hymenolepis nana for helminths were the most implicated co-infections.Conclusions: This study confirms that intestinal parasites are still a public health problem in Burkina Faso.To reduce the incidence of parasitic infections,it is necessary to promote the education of people so that they practice the rules of individual and collective hygiene. | Simplice Damintoti Karou Drissa Sanou Djeneba Ouermi Salvatore Pignatelli Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 1 |
| 18 | Study of Pineapple Peelings Processing into Vinegar by Biotechnology显示文摘 | Seyram K Sossou Yaovi Ameyapoh Simplice D Karou | 2009 | Pakistan Journal of Biological Sciences2009，12，11： | 1 |
| 19 | Catheter-based renal sympathetic denervation for resistant hypertension:durability of blood pressure reduction out to 24 months显示文摘 | Simplicity HTN-1 Investigators | | 0，，05： | 1 |
| 20 | Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial):a randomised controlled trial显示文摘 | Simplicity HTN-2 Investigators Esler MD Krum H | | 0，，9756： | 1 |
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