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| 1 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 2 | The collection of NFATcl-dependent transcripts in the osteoclast includes nuerous genes non -essential to physiologic bone resorption 显示文摘 | Julia F Fabienner Coury Rosalyn S | 2012 | Bone2012，51，： | 1 |
| 3 | Calcium regulates the PI3K-Akt pathway in stretched osteoblasts显示文摘 | Theodora Danciu Rosalyn | 2003 | FEBS Letters2003，536，： | 1 |
| 4 | Recombinant factor VIIa in the treatment of non-hemophiliac bleeding.显示文摘 | Masha SHL Rosalyn PSC | | 0，，： | 1 |
| 5 | Telephony-based voice pathology assess-ment using automated speech analysis显示文摘 | Moran Rosalyn J Reilly Richard B Philip de Chazal | 2006 | IEEE Transactions on Biomedical Engineering2006，53，3： | 1 |
| 6 | Earnings Persistence, Accruals and Managerial Share Ownership 显示文摘 | Rosalyn Oei Alan Ramsay Paul Mather | 2008 | Accounting and Finance2008，，48： | 1 |
| 7 | The Aerodynamics of free- flight maneuvers in drosophila 显示文摘 | Steven N F Rosalyn S Michael H D | 2003 | Science2003，300，： | 1 |
| 8 | Continuous improvement :ten essential criteria显示文摘 | Mike Kaye Rosalyn Anderson | 1999 | International Journal of Quality &Reliability Management1999，16，5： | 1 |
| 9 | Bone Segmentation and 3D Visualization of CT Images lbr Traumatic Pelvic Injuries 显示文摘 | WU Jie Ashwin Belle Rosalyn H Hargraves | 2014 | International Journal of Imaging Systems and Technology(S0899-9457)2014，24，1： | 1 |
| 10 | Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis显示文摘 | Rosalyn Díaz Ji Won Kim Jia-Ji Hui Zhaodong Li Gary P. Swain Keith S.K. Fong Katalin Csiszar Pierre A. Russo Elizabeth B. Rand Emma E. Furth Rebecca G. Wells | 2008 | Human Pathology2008，，1： | 1 |
| 11 | The cold‐shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production显示文摘 | Mohamed BAl‐Fageeh Rosalyn JMarchant Martin JCarden C MarkSmales | 2006 | Biotechnol Bioeng2006，，5： | 1 |
| 12 | Certain Unresolved Aspects of the Law of State Immunity 显示文摘 | Rosalyn Higgins | 1982 | Netherland International Law Review1982，29，2： | 1 |
| 13 | Dynamic Causal Models and Physiological Inference:AValidation Study Using Isoflurane Anaesthesia in Rodents显示文摘 | Rosalyn J Moran Fabienne Jung Tetsuya Kumagai | 2011 | PLoS ONE2011，6，22： | 1 |
| 14 | Out- break of Legionnaires' disease associated with a decorative fountain: an environmental and case - control study 显示文摘 | Rosalyn E OLoughlin L on Kightlinger Matthew C Werpy | 2007 | BMC Infectious Dis- ease2007，7，93： | 1 |
| 15 | Time and the Law: International Perspectives on an Old Problem 显示文摘 | Rosalyn Higgins | 1997 | International and Com- parative Law Quarterly1997，46，3： | 1 |
| 16 | Injectable Silk Foams for Soft Tissue Regeneration显示文摘 | Evangelia Bellas Tim J. Lo Eric P. Fournier Joseph E. Brown Rosalyn D. Abbott Eun S. Gil Kacey G. Marra J. Peter Rubin Gary G. Leisk David L. Kaplan | 2015 | Adv. Healthcare Mater2015，，3： | 1 |
| 17 | Risk factors for severe respiratory syncytial virus infection among alaska native children 显示文摘 | Lisa RB Rosalyn JS | 2002 | Pediatrics2002，109，： | 1 |
| 18 | Targeting the epidermal growth factor receptor in non-small-cell lung cancer: Who, which, when, and how?显示文摘 | Rosalyn Juergens MD Julie Brahmer MD MSc | 2007 | Current Oncology Reports2007，，4： | 1 |
| 19 | Loss of caveolin‐1 in prostate cancer stroma correlates with reduced relapse‐free survival and is functionally relevant to tumour progression显示文摘 | Gustavo Ayala Matteo Morello Anna Frolov Sungyong You Rile Li Fabiana Rosati Gianluca Bartolucci Giovanna Danza Rosalyn M Adam Timothy C Thompson Michael P Lisanti Michael R Freeman Dolores Di Vizio | 2013 | Pathol2013，，1： | 1 |
| 20 | 包膜挛缩的危险因素分析:一项SIENTRA圆形光面及毛面假体隆乳术的5年研究分析显示文摘背景与目的尽管有一些广泛认可的相关因素,但导致包膜挛缩的多层面的因素在近几十年内仍未解决。本研究将调查首次隆乳术患者导致包膜挛缩的一些潜在危险因素。方法本研究资料包含2560例首次隆乳术患者,假体5109只,由34位医师在5年内施行的SIENTRA临床研究结果。患者每年随访一次,记录包膜挛缩的Baker分级。潜在危险因素包括患者属性、假体属性、手术特征、腔隙冲洗和术后特征,对其进行频率和多变量模型分析。结果在5年中,共有179例患者的265只乳房假体发生包膜挛缩。由假体产生的包膜挛缩的总体Kaplan—Meier概率为7.6%。未调整的分析显示,以下因素会增加包膜挛缩的发生概率:光面假体、环乳晕切口、乳腺下层面置入、抗生素及类固醇腔隙冲洗、被建议按摩及外科胸罩(P值均〈0.05)。将所有危险因素调整为模型中的变量,其多变量分析的结果发现6种因素与包膜挛缩有独立关联(假体置入层次、假体表面、切口位置、血肿或血清肿发展、假体尺寸及外科胸罩;P值均〈0.05)。结论本研究分析证实,排除其他因素的情况下,肌肉下层次置人和选择毛面假体可显著减少包膜挛缩的发生。 | W. Grant Stevens Maurice Y. Nahabedian M. Bradley Calobrace Jennifer L. Harrington Peter J.Capizzi Robert Cohen Rosalyn C. d'Incelli Maggi Beckstrand 魏峰(译) 高景恒(译) 张晨(译) | 2014 | 中国美容整形外科杂志2014，25，2： | 1 |
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