2篇
您的检索式：作者名="Kenneth J.Pienta"
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| 1 | Metastatic prostate cancer remains incurable, why?显示文摘Metastatic prostate cancer patients present in two waysdwith already disseminated disease at the time of presentation or with disease recurrence after definitive local therapy.Androgen deprivation therapy is given as the most effective initial treatment to patients.However,after the initial response,almost all patients will eventually progress despite the low levels of testosterone.Disease at this stage is termed castration resistant prostate cancer(CRPC).Before 2010,the taxane docetaxel was the first and only life prolonging agent for metastatic CRPC(mCRPC).The last decade has witnessed robust progress in CRPC therapeutics development.Abiraterone,enzalutamide,apalutamide and sipuleucel-T have been evaluated as first-and second-line agents in mCRPC patients,while cabazitaxel was approved as a second-line treatment.Radium-223 dichloride was approved in symptomatic patients with bone metastases and no known visceral metastases pre-and post-docetaxel.However,despite significant advances,mCRPC remains a lethal disease.Both primary and acquired resistance have been observed in CRPC patients treated by these new agents.It could be solely cell intrinsic or it is possible that the clonal heterogeneity in treated tumors may result from the adaptive responses to the selective pressures within the tumor microenvironment.The aim of this review is to list current treatment agents of CRPC and summarize recent findings in therapeutic resistance mechanisms. | Liang Dong Richard C.Zieren Wei Xue Theo M.de Reijke Kenneth J.Pienta | 2019 | Asian Journal of Urology2019，6，1： | 9 |
| 2 | Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer显示文摘 | YusukeShiozawa Aaron M.Havens YounghunJung Anne M.Ziegler Elisabeth A.Pedersen JingchengWang JianhuaWang GanweiLu G. DavidRoodman Robert D.Loberg Kenneth J.Pienta Russell S.Taichman | 2008 | J Cell Biochem2008，，2： | 1 |
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