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| 1 | Genetic and epigenetic risks of intracytoplasmic sperm injection method显示文摘怀孕由帮助繁殖技术完成了,特别地由胞质内精子注射(ICSI ) 过程,产生对与 ICSI 对待的男人口固有的基因风险和对这个创新过程固有的另外的风险。记录,以及理论,风险在现在的评论学习被讨论。这些风险主要表示位于男性下面的基因畸形的后果代替生育力(或不孕) 并且可能在不孕的治疗为新奇途径和应用的发展成为激发器。另外,冒的风险,当先天的异例和另外的理论或随机的风险被讨论,一个复合基因背景出现在出生。最近的数据建议那种帮助繁殖技术可能也影响雄配子,雌配子,或力量的渐成说特征影响早胚胎开始。它可能也为印畸形的 genomic 与增加的风险被联系。 | Ioannis Georgiou Maria Syrrou Nicolaos Pardalidis Konstantinos Karakitsios Themis Mantzavinos Nikolaos Giotitsas Dimitrios Loutradis Fotis Dimitriadis Motoaki Saito Ikuo Miyagawa Pavlos Tzoumis Anastasios Sylakos Nikolaos Kanakas Theodoros Moustakareas Dimitrios Baltogiannis Stavros Touloupides Dimitrios Giannakis Michael Fatouros Nikolaos Sofikitis | 2006 | Asian Journal of Andrology2006，8，6： | 9 |
| 2 | Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver显示文摘AIM To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genesin zebrafish.METHODS Zebrafish(n = 104),wild type,adult,male and female,were divided into two groups:Control and ethanol(0.05 v/v).The ethanol was directly added into water;tanks water were changed every two days and the ethanol replaced.The animals were fed twice a day with fish food until satiety.After two and four weeks of trial,livers were dissected,histological analysis(hematoxilineosin and Oil Red staining) and gene expression assessment of adiponectin,adiponectin receptor 2(adipor2),sirtuin-1(sirt-1),tumor necrosis factor-alpha(tnf-a),interleukin-1b(il-1b) and interleukin-10(il-10) were performed.Ultrastructural evaluations were conducted at fourth week.RESULTS Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks,as demonstrated by oil red staining.In ethanol-treated animals,the main ultrastructural changes were related to cytoplasmic lipid particles and droplets,increased number of rough endoplasmic reticulum cisterns and glycogen particles.Between two and four weeks,hepatic mR NA expression of il-1b,sirt-1 and adipor2 were upregulated,indicating that ethanol triggered signaling molecules which are key elements in both hepatic inflammatory and protective responses.Adiponectin was not detected in the liver of animals exposed and not exposed to ethanol,and il-10 did not show significant difference.CONCLUSION Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol. | Ana Claudia Reis Schneider Cleandra Gregório Carolina Uribe-Cruz Ranieli Guizzo Tais Malysz Maria Cristina Faccioni-Heuser Larisse Longo Themis Reverbel da Silveira | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Cirrhosis in children and adolescents: An overview显示文摘Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. Most cases in clinical practice are caused by similar etiologies. In infants, cirrhosis is most often caused by biliary atresia and genetic-metabolic diseases, while in older children, it tends to result from autoimmune hepatitis,Wilson's disease, alpha-1-antitrypsin deficiency and primary sclerosing cholangitis. The symptoms of cirrhosis in children and adolescents are similar to those of adults. However, in pediatric patients, the first sign of cirrhosis is often poor weight gain. The complications of pediatric cirrhosis are similar to those observed in adult patients, and include gastrointestinal bleeding caused by gastroesophageal varices, ascites and spontaneous bacterial peritonitis. In pediatric patients, special attention should be paid to the nutritional alterations caused by cirrhosis, since children and adolescents have higher nutritional requirements for growth and development. Children and adolescents with chronic cholestasis are at risk for several nutritional deficiencies. Malnutrition can have severe consequences for both pre- and post-liver transplant patients. The treatment of cirrhosis-induced portal hypertension in children and adolescents is mostly based on methods developed for adults. The present article will review the diagnostic and differential diagnostic aspects of end-stage liver disease in children, as well as the major treatment options for this condition. | Raquel Borges Pinto Ana Claudia Reis Schneider Themis Reverbel da Silveira | 2015 | World Journal of Hepatology2015，7，3： | 3 |
| 4 | Molecular characterization of field azoxystrobin-resistant isolates of Botrytis cinerea显示文摘 | JIANG J H DING L S THEMIS J | 2009 | Pestic Biochem Phys2009，93，2： | 1 |
| 5 | Gene therapy progress and prospects: Fetal gene therapy-first proofs of conceptsome adverse effects 显示文摘 | Coutelle C Themis M Waddington S N | 2005 | Gene Ther2005，12，： | 1 |
| 6 | Retroviral gene transfer to the liver in vivo during triodothyronine induced hyperplasia 显示文摘 | Forties S J Themis M Alison M R | 1998 | Gene Therapy1998，5，5： | 1 |
| 7 | Ranking university departments using the mean h - index 显示文摘 | THEMIS L | 2010 | Scientometrics2010，82，2： | 1 |
| 8 | Advances in under- standing molecular mechanisms of fungicide resistance and molecular detection of resistant genotypes in phytopatho- genic fungi 显示文摘 | Zhonghua Ma Themis J Michailides | 2005 | Crop Protection2005，，24： | 1 |
| 9 | Progress in understanding molecular mechanisms and evolution of resistance to succinate dehy drogenase inhibiting(SDHI) fungicides in phytopathogenie fungi显示文摘 | Herve F Avenot Themis J Michailides | 2010 | Crop Protection2010，29，： | 1 |
| 10 | Resistance to Boscalid Fungicide in Alternaria alternata Isolates from Pistachio in California显示文摘 | Herve F Avenot Themis J Michailides | 2007 | Plant Disease2007，91，： | 1 |
| 11 | Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in children and adolescents显示文摘 | Etienne M. Sokal Annick Bourgois Xavier Stéphenne Themis Silveira Gilda Porta Dace Gardovska Bj?rn Fischler Deirdre Kelly | 2010 | Journal of Hepatology2010，，6： | 1 |
| 12 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro 显示文摘 | Tolmachov O Ma Y L Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 13 | Resistance to azoxystrobin in Aternaria isolates from pistachio in California 显示文摘 | Ma Z H Dan F Themis J M | 2003 | Pesticide Biochemistry and Physiology2003，，66： | 1 |
| 14 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro 显示文摘 | Tolmachov O Ma Y L Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 15 | Web Search Using a Genetic Algorithms显示文摘 | Nick Z Themis P | 2001 | IEEE Internet Computing2001，，3： | 1 |
| 16 | Prospective Randomized Comparison of Chemoembolization with Doxorubicin-Eluting Beads and Bland Embolization with BeadBlock for Hepatocellular Carcinoma显示文摘 | Katerina Malagari Mary Pomoni Alexis Kelekis Anastasia Pomoni Spyros Dourakis Themis Spyridopoulos Hippokratis Moschouris Emmanouil Emmanouil Spyros Rizos Dimitrios Kelekis | 2010 | CardioVascular and Interventional Radiology2010，，3： | 1 |
| 17 | Michailides, Genetic structure of Botrytis cinerea populations from different host plants in California显示文摘 | Zhonghua Ma Themis J | 2005 | Plant Disease2005，89，10： | 1 |
| 18 | Excess nitrogen raises nectarine susceptibility to disease and insects显示文摘 | KENT M D JOHNSON R S THEMIS J M | 1995 | California Agriculture1995，49，4： | 1 |
| 19 | Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro显示文摘 | Tolmachov O Ma YL Themis M | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 20 | Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1显示文摘 | Eden ER Patel DD Sun XM Burden JJ Themis M Edwards M | 2002 | J Clin Invest2002，110，11： | 1 |
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