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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome:A randomized,double-blind study显示文摘AIM:To assess the effects and safety of Lactobacillus casei rhamnosus LCR35 complete freeze-dried culture(LCR35) in patients suffering from irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in 50 patients complaining of IBS symptoms complying with RomeⅢcriteria.Patients were allocated to receive either LCR35(n = 25) at a minimum daily dose of 6 × 108 colony forming units or placebo(n = 25) for 4 wk.At inclusion,after treatment and 2 wk later,patients completed the IBS severity scale.Change from baseline in the IBS severity score at the end of treatment was the primary efficacy criterion.Changes were compared between groups in the whole population and in IBS subtypes(IBS with predominance of constipation,IBS with predominance of diarrhoea,mixed IBS,unsubtyped IBS).The presence of lactobacillus casei rhamnosus in stools was investigated at inclusion and at the end of treatment.The gastrointestinal quality of life questionnaire and the hospital anxiety and depression(HAD) scale were also completed.RESULTS:Both groups were balanced for baseline characteristics.In 85% of patients,stool analyses showed that lactobacillus casei rhamnosus able to survive in the digestive tract.In the whole population,improvements in the IBS severity score did not differ significantly between treatments with a 25% decrease after 4-wk treatment,and a 15% decrease from baseline 2 wk later in both groups.In IBS subgroups,statistical analysis could not be performed due to small sample size,but a clinical response in favour of LCR35 was observed in IBS patients with predominance of diarrhoea:no change in the symptom severity score was seen with the placebo after 4 wk treatment,whereas a clinically relevant decrease occurred with LCR35(-37% vs-3%).Furthermore,in spite of an increase in symptom intensity,the IBS severity score was maintained below the baseline value 2 wk later with LCR35(-19% from baseline),whilst a slight 5% increase from baseline was observed with placebo.In the IBS subgroup with predominance of diarrhoea only,a clinically relevant decrease in abdominal pain severity score(-36%)was observed with LCR35,whereas no change occurred with placebo.In mixed IBS patients,the 20% and 30% decreases in the IBS severity score observed after treatment with LCR35 and placebo,respectively,were maintained 2 wk later in both groups.A clinical response slightly in favour of placebo was observed at the end of the treatment period in IBS patients with predominance of constipation(-41% vs-20%) and unsubtyped IBS patients(-47% vs-17%),with the same value maintained 2 wk later.In both groups,no clinically relevant changes were observed either for the gastrointestinal quality of life index or HAD score.Thus,these results suggest that sub-grouping of IBS patients may be important for optimizing treatment responses by the physician.CONCLUSION:This pilot study suggests that LCR35 could have some efficacy in IBS patients complaining of diarrhoea.These preliminary results need to be conf irmed in larger studies. | Michel Dapoigny Thierry Piche Philippe Ducrotte Bernard Lunaud Jean-Michel Cardot Annick Bernalier-Donadille | 2012 | World Journal of Gastroenterology2012，18，17： | 10 |
| 3 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 4 | Nickel ferrite spinel as catalyst precursor in the dry reforming of methane:Synthesis,characterization and catalytic properties显示文摘Dry reforming of methane by CO2 using nickel ferrite as precursor of catalysts was investigated.Nickel ferrite crystalline particles were prepared by coprecipitation of nitrates with NaOH or ammonia followed by calcination,or by hydrothermal synthesis without calcination step.The textural and structural properties were determined by a number of analysis methods,including X-ray diffraction (XRD),Raman spectroscopy and X-ray photoelectron spectroscopy (XPS),among which X-ray diffraction (XRD) was at room and variable temperatures.All synthesized oxides showed the presence of micro or nanoparticles of NiFe2O4 inverse spinel,but Fe2O3 (hematite) was also present when ammonia was used for coprecipitation.The reducibility by hydrogen was studied by temperature-programmed reduction (TPR) and in situ XRD,which showed the influence of the preparation method.The surface area (BET),particle size (Rietveld refinement),as well as surface Ni/Fe atomic ratio (XPS) and the behavior upon reduction varied according to the synthesis method.The catalytic reactivity was investigated using isopropanol decomposition to determine the acid/base properties.The catalytic performance of methane reforming with CO2 was measured with and without the pre-treatment of catalysts under H2 in 650-800 C range.The catalytic conversions of methane and CO2 were quite low but they increased when the catalysts were pre-reduced.A significant contribution of reverse water gas shift reaction accounted for the low values of H2 /CO ratio.No coking was observed as shown by the reoxidation step performed after the catalytic reactions.The possible formation of nickel-iron alloy observed during the study of reducibility by hydrogen was invoked to account for the catalytic behavior. | Rafik Benrabaa Hamza Boukhlouf Axel Lfberg Annick Rubbens Rose-Nelle Vannier Elisabeth Bordes-Richard Akila Barama | 2012 | Journal of Natural Gas Chemistry2012，21，5： | 5 |
| 5 | 2010-2015年全球实验室网络支持的消除麻疹和风疹工作的进展显示文摘2012年,世界卫生大会(World Health Assembly)签署全球疫苗行动计划(Global Vaccine Action Plan,GVAP),该计划旨在2020年前消除世界卫生组织(World Health Qrganization,WHO)5个区域的麻疹和风疹。2013年9月,WHO 6个区域的所有国家都已确立消除麻疹的目标,其中3个区域还确立了消除风疹和先天性风疹综合征的目标. | mick n.mulders paul a.rota joseph p.icenogle kevin e.brown makoto takeda gloria j.rey myriam c.ben mamou annick r.g.a.dosseh charles r.byabamazima hinda j.ahmed sirima pattamadilok yan zhang marta gacic-dobo peter m.strebel james l.goodson 周惠嘉(翻译) | 2018 | 上海预防医学2018，30，2： | 4 |
| 6 | Decrease in uric acid in acute ischemic stroke correlates with stroke severity, evolution and outcome显示文摘 | Raf Brouns Annick Wauters Gerda Van De Vijver Didier De Surgeloose Rishi Sheorajpanday Peter P. De Deyn | 2010 | Clinical Chemistry and Laboratory Medicine2010，，3： | 3 |
| 7 | Hip joint center localisation: A biomechanical application to hip arthroplasty population显示文摘AIM: To determine hip joint center(HJC) location on hip arthroplasty population comparing predictive and functional approaches with radiographic measurements.METHODS: The distance between the HJC and the mid-pelvis was calculated and compared between the three approaches. The localisation error between the predictive and functional approach was compared using the radiographic measurements as the reference. The operated leg was compared to the non-operated leg.RESULTS: A significant difference was found for the distance between the HJC and the mid-pelvis when comparing the predictive and functional method. The functional method leads to fewer errors. A statistical difference was found for the localization error between the predictive and functional method. The functional method is twice more precise.CONCLUSION: Although being more individualized, the functional method improves HJC localization and should be used in three-dimensional gait analysis. | Vicky Bouffard Mickael Begon Annick Champagne Payam Farhadnia Pascal-André Vendittoli Martin Lavigne Franois Prince | 2012 | World Journal of Orthopedics2012，3，8： | 3 |
| 8 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 9 | 聚焦离子束在金属研究中的应用显示文摘由于聚焦离子束(Focused Ion Beam,简称FIB)显微镜的最新运用,材料科学得以迅速发展。钢铁行业中,聚焦离子束技术不仅可以不断将涂料和钝化层变薄,而且特别适用于多相或成分混杂的和/或多孔材料的透射电子显微镜(Transmission Electron Microscope,简称TEM)薄片制备。四年前,在ArcelorMittal Gent设备上安装了三重束聚焦离子束仪器。随后利用该仪器对大量的各种各样的材料进行筛选和/或处理,以进一步进行TEM分析。FIB技术成功运用于图层、基体和界面研究领域。比如:1)图层应用:厚度均匀性、缺损性及腐蚀研究;2)衬底分析:裂纹扩展、晶界及晶粒取向;3)界面分析:金属间(化合的)相、扩散和偏聚,外延研究。由于FIB仪器的高成本性以及配套需要的专业操作技能,毫无疑问局限了其在钢铁研究中的日常应用。不过,仍然可以从聚焦离子束制备样品的独特方式中获得许多经济效益,比如更短的样品制备时间、对抽样区域的选择性,当然还有人为因素的影响极其有限。因此,通常情况下,FIB样品制备成为唯一一种可以用于制备透射电子显微镜薄片的途径。FIB同TEM的联用分析技术开启了一个化学的、微结构和晶体信息的新世界,这种新领域将在以下研究中得以体现:1)锌-铝-镁涂层的共晶相表征;2)富铬钝化层的缺损学研究;3)耐候钢的结构组成;4)无锌涂层的微结构:铝/镁显示为纳米晶体状的铝镁多相结构。 | XHOFFER Chris DHONT Annick WILLEMS Annick | 2012 | 冶金分析2012，32，7： | 2 |
| 10 | HBV induced carcinogenesis显示文摘 | Delphine Cougot Christine Neuveut Marie Annick Buendia | 2005 | Journal of Clinical Virology2005，，： | 2 |
| 11 | Agricultural land-use change and its drivers in mountain landscapes: A case study in the Pyrenees显示文摘 | Anne Mottet Sylvie Ladet Nathalie Coqué Annick Gibon | 2005 | Agriculture Ecosystems and Environment2005，，2： | 2 |
| 12 | Mechanisms of HBV-related hepatocarcinogenesis显示文摘 | Christine Neuveut Yu Wei Marie Annick Buendia | 2009 | Journal of Hepatology2009，，4： | 2 |
| 13 | 在急性卒中的血压管理中我们(不)了解什么?显示文摘尽管治疗高血压在预防首发或复发性卒中中的作用不容置疑,但对卒中后最初数小时或数天内的高血压管理仍存在争论。80%的卒中患者在发病后数天内有血压升高,尚缺乏来自随机对照试验的高质量证据指导其治疗。理论上,对卒中发病后的血压管理有正反两方面的争论意见。大多数治疗指南建议根据病理生理学原理不对血压进行处理。但是,对随机试验的事后分析提示血压升高与复发性卒中和高病死率有关,即使在校正混杂因素后亦如此。另一方面,初步研究表明,经过选择的患者亚组人为地升高血压可能是有益的。在本综述中,我们对有关这一课题的最新研究做一概括。 | Annick Verstappen Vincent Thijs 卢林 李义召 | 2006 | 国际脑血管病杂志2006，14，12： | 2 |
| 14 | Dihydrosphingosine-lnduced Programmed Cell Death in Tobacco BY-2 Cells Is Independent of H2O2 Production显示文摘 | Christophe Lachaud | 2011 | Molecular Plant2011，4，2： | 2 |
| 15 | Prominent and Persistent Extraneural Infection in Human PrP Trausgenic Mice Infected with Variant CJD显示文摘 | Vincent Beringue Annick Le Dur Philippe Tixador | 2008 | PLoS ONF2008，，1： | 1 |
| 16 | D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function显示文摘 | Masato Sasaki Christiane B. Knobbe Momoe Itsumi Andrew J. Elia Isaac S. Harris Iok In Christine Chio Rob A. Cairns Susan McCracken Andrew Wakeham Jillian Haight Annick You Ten Bryan Snow Takeshi Ueda Satoshi Inoue Kazuo Yamamoto Myunggon Ko Anjana Rao Kat | 2012 | Genes & Development2012，，18： | 1 |
| 17 | Gout-associated uric acid crystals activate theNALP3 inflammasome显示文摘 | Fabio Martinon Virginie Petrilli Annick Mayor | | 0，，： | 1 |
| 18 | Bevacizumab plus irinotecan in recurrent glioblastoma multiforme显示文摘 | James J Vredenburgh Annick Desjardins James E Herndon | 2007 | J Clin Oncol2007，25，30： | 1 |
| 19 | The effect of changing ration ingredients on acid status,renal function,and macromineral metabolism显示文摘 | Ellion Block | 1995 | J Dairy Sci1995，78，： | 1 |
| 20 | Residual alkalinity as tracer to estimate the changes indueed by forage cultivation in a non-saline irrigated sodic soil显示文摘 | Laurent B Vincent V Annick R | 2001 | Agricultural Water Management2001，50，3： | 1 |
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