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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | The bone marrow functionally contributes to liver fibrosis显示文摘 | Russo F P Alison M R Bigger B W | 2006 | Gastroenterology2006，130，6： | 1 |
| 3 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 4 | Cancer stem cells:problems for therapy显示文摘 | Alison M R Lira S M Nieholson L J | 2011 | JPathol2011，223，2： | 1 |
| 5 | Antiepileptie drugs:Are women aware of interactions with oral contraceptivesand potential teratogenicity?显示文摘 | Alison M P Anne R D Kritzer J | 2009 | Epilepsy & Behavior2009，4，14： | 1 |
| 6 | Retroviral gene transfer to the liver in vivo during triodothyronine induced hyperplasia 显示文摘 | Forties S J Themis M Alison M R | 1998 | Gene Therapy1998，5，5： | 1 |
| 7 | The new stem cell biology:something for every显示文摘 | Preston S L Alison M R Forbes S J | 2003 | J Clin Pathol:Mol Pathol2003，56，： | 1 |
| 8 | Neurode- velopmental effects of lanthanum in mice 显示文摘 | WAYNE B ROBERT F R ALISON M | 2000 | Neurotoxi- cology and Teratology2000，22，： | 1 |
| 9 | Some Local Environmental Effects onMercury Emission and Absorption at a Soil Surface显示文摘 | ALISON A G DAVID R M | 2000 | Science ofthe Total Environment2000，260，123： | 1 |
| 10 | A model for bipolar charge transport, trapping and recombination in degassed crosslinked polyethene显示文摘 | Alison J M Hill R M | 1994 | Journal of Physics D: Applied Physics1994，27，6： | 1 |
| 11 | Hepatocytes from non-hepatic adult stem cells显示文摘 | ALISON M R POULSOM R JEFFERY R | 2000 | Nature2000，406，： | 1 |
| 12 | An introduction to stem cells显示文摘 | Alison M R Poulsom R Forbes S | 2002 | J Pathol2002，197，： | 1 |
| 13 | Adult stem cell plasticity显示文摘 | Roulsom R Alison M R Forbesl S J | 2002 | J Pathol2002，197，： | 1 |
| 14 | Cancer stem cells: in the line of fire显示文摘 | Alison M R Lin W R Lira S M L | 2012 | Cancer Treat Rev2012，38，6： | 1 |
| 15 | Hepatocytes from non - hepatic adult stem cells 显示文摘 | ALISON M R POULSOM R JEFFERY R | 2000 | Nature2000，406，6793： | 1 |
| 16 | Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? 显示文摘 | ALISON M R GUPPY N J LIM S M | 2010 | J Pathol2010，222，4： | 1 |
| 17 | Application of liver stem cells for cell therapy显示文摘 | ALISON M R CHOONG C LIM S | 2007 | Semin Cell Dev Biol2007，18，6： | 1 |
| 18 | A introduction to stem cells显示文摘 | Alison M R Poulsom R Forbes S | 2002 | J Pathol2002，197，： | 1 |
| 19 | Spatiotemporal patterning of reactive oxygen production and Ca^2+ wave propagation in Fucus Rhizoid cells 显示文摘 | Susana M C Alison R T Keith P R | 2002 | Plant Cell2002，14，： | 1 |
| 20 | Regulation of heaptic growthr显示文摘 | Alison M R | 1986 | Physiol Rev1986，66，3： | 1 |
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