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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 5 | Hepatic and extrahepatic malignancies in primary sclerosing cholangitis显示文摘 | Annika Bergquist Anders Ekbom Rolf Olsson Dan Kornfeldt Lars L??f ?ke Danielsson Rolf Hultcrantz Stefan Lindgren Hanne Prytz Hanna Sandberg-Gertzén Sven Almer Fredrik Granath Ulrika Broomé | 2002 | Journal of Hepatology2002，，3： | 2 |
| 6 | Incidence and Morphology of the Posteromedial Fragment in Bicondylar Tibial Plateau Fractures显示文摘 | Thomas F Higgins Dan Kemper Joshua Klatt | 2009 | Journal of Orthopaedic Trauma2009，，1： | 2 |
| 7 | Silkroute-trading between relation and XML显示文摘 | Wang C T Dan S | 2000 | Computer Networks2000，33，： | 1 |
| 8 | Silkroute- trading between relation and XML显示文摘 | Wang C Dan S | 2000 | Computer Networks2000，33，： | 1 |
| 9 | Redundancy of Structural Systems with and Without Maintenance : An Approach Based on Lifetime Functions显示文摘 | Nader M O Dan M F | 2010 | Reliability Engineering and System Safety2010，95，5： | 1 |
| 10 | Polyphenols from Ginkgo biloba 显示文摘 | Qa'dan F Nahrstedt A Schmidt M | 2010 | Sci Pharrn2010，78，： | 1 |
| 11 | phosphorus speciation and sorption- desorption characteristics in heavily manured soils 显示文摘 | Dan Z X Ramberg C F Toth J D | 2009 | Soil Science Society of America2009，73，： | 1 |
| 12 | Pair Box 8 ( PAX8 ) protein expression in high grade, late stage ( stage III And 1V ) ovarian serous carcinoma显示文摘 | Paulette M F Dan W Damanzoopinder S | 2012 | Gynecol Onco}2012，127，1： | 1 |
| 13 | Photocatalytie activity of poly(3-hexylthiophene) titanium dioxide composites for degrading methyl orange 显示文摘 | Zhu Y F Dan Y | 2010 | Solar Energy Materials and Solar Cells2010，94，10： | 1 |
| 14 | Improved assessment of mass concrete dams using acoustic travel time tomography :part Ⅰ -theory 显示文摘 | LEONARD J B WILLIAM F K DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 15 | Control of an interconnected power system:a time delay approach显示文摘 | Dan I Aaron F S Jean-Michel Dion | 2002 | IMA Journal of Mathematical Control and Information2002，19，1： | 1 |
| 16 | Improved assessment of mass concrete dams using acoustic travel time tomography: part Ⅱ-applieation显示文摘 | WILLIAM F K LEONARD J B DAN M F | 2000 | Construction and Building Materials2000，14，3： | 1 |
| 17 | Isozyme inheritance and variation in Actindia显示文摘 | Huang H W Dan F Wang Z | 1997 | Heredity1997，78，： | 1 |
| 18 | How conservatively can postoperative small bowel obstruction be treatedl显示文摘 | ELAD F AMIS S | 1993 | Am J Surg1993，165，1： | 1 |
| 19 | Probabilistic analysis of resistance degradation of reinforced concrete bridge beams under corrosion显示文摘 | MICHAEL P E DAN M F | 1998 | Engineering Structures1998，，20： | 1 |
| 20 | Wave propagation simulation in a linear viscoelastic medium显示文摘 | lose M Carcione Dan Kosloff Ronnie Koslo{f | 1988 | 3eophysical Journal1988，95，： | 1 |
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