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| 1 | Late Mesozoic Tectonic Evolution of Southwestern Fujian Province,South China:Constraints from Magnetic Fabric,Zircon U-Pb Geochronology and Structural Deformation显示文摘A combined study of magnetic fabrics, zircon U-Pb geochronology and structural deformation was carried out for Late Paleozoic sedimentary and Mesozoic magmatic rocks in the southwestern Fujian rift basin, South China, aiming at deciphering the tectonic evolution during Late Mesozoic. Field observations showed that the Late Mesozoic structure deformations in southwestern Fujian were categorized into four phases: NW-SE compression, ENE-WSW extension, NNE-SSW compression and NNW-SSE extension, sequentially. Zircons picked out from Juzhou granite and WNW-trending diabase dykes showed complete crystal shapes and clear oscillatory zonings on their edges, and the U-Pb dating yielded ages of 132 and 141 Ma, respectively. The susceptibility ellipsoid magnitude parameters of the Juzhou granite are characterized by flaser type strain ellipsoid, with pole density center of K3 falling into the first and the third quadrants, these features revealed that the Juzhou granite formed in ENE-WSW compressional stress field, indicating the early stage of Early Cretaceous extrusion in southwestern Fujian. The late stage of Early Cretaceous NNE-SSW extension was limited by the widespread WNW-trending diabase dykes, which were usually regarded as important indications for a regional extensional setting. On the basic of the previous researches, structural deformation studies, and the deductions above, it can be concluded that southwestern Fujian experienced five main tectonic stages during Late Mesozoic: Early Jurassic extension, Middle–Late Jurassic thrusting, early stage of Early Cretaceous extension, late stage of Early Cretaceous compression and Late Cretaceous extension. | Sen Wang Da Zhang Ganguo Wu Xingjian Li Xiaoqiao Gao Absai Vatuva Yuan Yuan Tengda Yu Yu Bai Ye Fang | 2018 | Journal of Earth Science2018，29，2： | 4 |
| 2 | Cu^(Ⅱ)-loaded polydopaminecoatingswith in situ nitric oxidegenerationfunctionforimproved hemocompatibility显示文摘NO is the earliest discovered gas signal molecule which is produced by normal healthy endothelial cells,and it has many functions,such as maintaining cardiovascular homeostasis,regulating vasodilation,inhibiting intimal hyperplasia and preventing atherosclerosis in the blood system.Insufficient NO release is often observed in the pathological environment,for instance atherosclerosis.It was discovered that NO could be released from the human endogenous NO donor by many compounds,and these methods can be used for the treatment of certain diseases in the blood system.In this work,a series of copper-loaded polydopamine(PDA)coatings were produced through self-polymerization time for 24,48 and 72 h.The chemical composition and structure,coating thickness and hydrophilicity of the different copper-loaded PDA coatings surfaces were characterized by phenol hydroxyl quantitative,X-ray photoelectron spectroscopy,ellipsometry atomic force microscopy and water contact angles.The results indicate that the thickness and the surface phenolic hydroxyl density of the PDA coatings increased with the polymerization time.This copperloaded coating has glutathione peroxidase-like activity,and it has the capability of catalyzing NO releasing from GSNO.The surface of the coating showed desirable hemocompatibility,the adhesion and activation of platelets were inhibited on the copper-loaded coatings.At the same time,the formation of the thrombosis was also suppressed.These copper-loaded PDA coatings could provide a promising platform for the development of blood contact materials. | Lei Zhou Xin Li Kebing Wang Fangyu Shen Lu Zhang Peichuang Li Tengda Shang Jin Wang Nan Huang | 2020 | Regenerative Biomaterials2020，7，2： | 0 |
| 3 | Based on network pharmacology to explore the mechanism of nephrotoxicity of Xanthii Fructus显示文摘Objective:To explore the potential mechanism of nephrotoxicity induced by Xanthii Fructus(XF)through network pharmacology.Methods:The active ingredients and targets of XF were screened through Traditional Chinese Medicine Systems Pharmacology Database,PubChem Database and Swiss Target Prediction Database,and the related pathogenic genes of nephrotoxicity were downloaded from Genecards,pharmGKB and OMIM databases.The potential target is the intersection of XF and the pathogenic gene of nephrotoxicity.Cytoscape software was used to construct a network of“XF-Potential active ingredient-Target-Nephrotoxicity network”.Protein protein interaction(PPI)network was constructed by String database,and the data was analyzed and sorted out to obtain the key active components and core target proteins of XF.GO functional enrichment analysis and KEGG pathway enrichment analysis of key target proteins were performed by R software.Results:11 active components,167 targets,6839 nephrotoxicity related pathogenic genes and 139 intersection target genes were screened from XF.After constructing the network of“XF-Potential active ingredient-target-nephrotoxicity network”and PPI network,the key active ingredients of XF were identified as Moupinamide,Beta-sitosterol and Stigmasterol,and the core target proteins were CASP3,HSP90AA1 and TP53.There were 2072 GO entries(P<0.05),including 1876 Biological Process(BP),64 Cellular Component(CC)and 132 Molecular Function(MF).KEGG enrichment analysis revealed 138 pathways(P<0.05),mainly involving p53 signaling pathway,IL-17 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the nephrotoxicity of XF.Conclusion:The core target protein of XF HSP90AA1,CASP3 and TP53 participate in p53 signaling Pathway,PI3K-Akt signaling Pathway,IL-17 signaling Pathway and other pathways to regulate apoptosis and induce inflammatory responses,resulting in kidney damage. | Tao Chen Tengda Li Wenna Zhang Yulin Song Yuman Tang Rui Gong Hua Jin | 2022 | Asian Toxicology Tesearch2022，4，1： | 0 |
| 4 | Compositional characteristics and toxicological responses of human lung epithelial cells to inhalable particles (PM_(10)) from ten typical biomass fuel combustions显示文摘As the primary component of haze,atmospheric inhalable particulate matters(PMio)are highly detri-mental to human health.Biomass combustion is one of China's most pivotal sources to aerosols pollution,inducing non-negligible emissions and uncertain risks.PMio samples directly from 10 representative biomass fuel combustion sources(2 groups covering the reality widely:straws of rice,wheat,corn,corncob,soybean,peanut,rape,sesame;and branches of pine,peach)were collected using the dilution channel sampler and analyzed for chemical compositions and in vitro cytotoxicity to human lung epithelial cell lines A549.The components of PMio are dominated by organic carbon(OC),followed by Water-soluble K+and Cl,and rich in metals Fe,Zn,Cr,and Ni.Generally,PMio emitted from biomass fuel combustions can weaken the antioxidant capacity of cells,and straws emissions,especially rape and peanut straws,show stronger ability to further induce oxidative stress and inflammatory damage than fuelwoods,owing to the key toxic roles of Cr,Ni,and Co.Therefore,reducing the specific source emis--sions of PMio from crop straw combustions rich in heavy metals could be an effective oriented strategy to improve environmental air quality and control aerosols pollution precisely for protecting public health. | Hanhan Li Mingwei Tang Xiaosan Luo Weijun Li Yuting Pang Weijie Huang Zhen Zhao Yaqian Wei Tengda Long Tariq Mehmood | 2023 | Particuology2023，，7： | 0 |
| 5 | Improved corrosion resistance and biocompatibility of biomedical magnesium alloy with polypeptide TK14 functionalised hydrophobic coating显示文摘Magnesium(Mg)and its alloys can be used as biomedical materials because of their excellent mechanical properties and biocompatibility.However,the rapid degradation rate of Mg-based materials limits their application in biodegradable intravascular stents.To overcome this issue,we constructed a hydrophobic coating on magnesium.After pre-treatments with alkali and a silane coupling agent of pure magnesium,4,4’-diphenyl-methane-diisocyanate(MDI)and amino-terminated polydimethylsiloxane(H_(2)N-PDMS-NH_(2))were stepwise deposited on the surface,forming an amino-containing hydrophobic coating(-(M/P)_(3))to enhance the corrosion resistance.Furthermore,polypeptide TK14 was immobilised on the hydrophobic coating to promote vascular endothelial cell adhesion and proliferation.The electrochemical results revealed that the self-corrosion current density(i_(corr))of-(M/P)_(3) decreased by approximately 4.5 orders of magnitude compared with that of pure Mg.After TK14 immobilisation,the number of endothelial cells adhering to the surface of-(M/P)_(3)-T increased significantly.Although the corrosion resistance of-(M/P)_(3)-T was slightly reduced,the subcutaneous implantation inflam-matory response of the surrounding tissues was lower,showing suitable biocompatibility.Therefore,the polypeptide TK14 functionalised hydrophobic coating may be a promising candidate material for the interface of magnesium-based cardiovascular implants. | Yang Shen Xiaolong Shen Hao Zhang Xin Li Tengda Shang Yuancong Zhao Jin Wang Nan Huang | 2021 | Biosurface and Biotribology2021，7，1： | 0 |
| 6 | Fate of organophosphate esters from the Northwestern Pacific to the Southern Ocean:Occurrence,distribution,and fugacity model simulation显示文摘Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in seawater.Two halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross Sea.The model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE sink.Dry and wet deposition dominated the processes involving OPE transfer to seawater.The OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater region.These findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic. | Tengda Shi Ruijing Li Jie Fu Chao Hou Hui Gao Guanjie Cheng Haibo Zhang Shuaichen Jin Liang Kong Guangshui Na | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 7 | Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality显示文摘Many polyurethanes(PUs)are blood-contacting materials due to their good mechanical properties,fatigue resistance,cytocompatibility,biosafety,and relatively good hemocompatibility.Further functionalization of the PUs using chemical synthetic methods is especially attractive for expanding their applications.Herein,a series of catechol functionalized PU(CPU-PTMEG)elastomers containing variable molecular weight of polytetramethylene ether glycol(PTMEG)soft segment are reported by stepwise polymerization and further introduction of catechol.Tailoring the molecular weight of PTMEG fragment enables a regulable catechol content,mobility of the chain segment,hydrogen bond and microphase separation of the C-PUPTMEG elastomers,thus offering tunability of mechanical strength(such as breaking strength from 1.3 MPa to 5.7 MPa),adhesion,self-healing eficiency(from 14.9%to 96.7%within 2 hours),anticoagulant,antioxidation,anti-inflammatory properties and cellular growth behavior.As cardiovascular stent coatings,the C-PU-PTMEGs demonstrate enough flexibility to withstand deformation during the balloon dilation procedure.Of special importance is that the C-PU-PTMEG-coated surfaces show the ability to rapidly scavenge free radicals to maintain normal growth of endothelial cells,inhibit smooth muscle cell proliferation,mediate inflammatory response,and reduce thrombus formation.With the universality of surface adhesion and tunable multifunctionality,these novel C-PU-PTMEG elastomers should find potential usage in artificial heart valves and surface engineering of stents. | Lei Zhou Lu Zhang Peichuang Li Manfred F.Maitz Kebing Wang Tengda Shang Sheng Dai Yudie Fu Yuancong Zhao Zhilu Yang Jin Wang Xin Li | 2023 | Research2023，，1： | 0 |
| 8 | An Intelligent Algorithm for Solving Weapon-Target Assignment Problem:DDPG-DNPE Algorithm显示文摘Aiming at the problems of traditional dynamic weapon-target assignment algorithms in command decisionmaking,such as large computational amount,slow solution speed,and low calculation accuracy,combined with deep reinforcement learning theory,an improved Deep Deterministic Policy Gradient algorithm with dual noise and prioritized experience replay is proposed,which uses a double noise mechanism to expand the search range of the action,and introduces a priority experience playback mechanism to effectively achieve data utilization.Finally,the algorithm is simulated and validated on the ground-to-air countermeasures digital battlefield.The results of the experiment show that,under the framework of the deep neural network for intelligent weapon-target assignment proposed in this paper,compared to the traditional RELU algorithm,the agent trained with reinforcement learning algorithms,such asDeepDeterministic Policy Gradient algorithm,Asynchronous Advantage Actor-Critic algorithm,Deep Q Network algorithm performs better.It shows that the use of deep reinforcement learning algorithms to solve the weapon-target assignment problem in the field of air defense operations is scientific.In contrast to other reinforcement learning algorithms,the agent trained by the improved Deep Deterministic Policy Gradient algorithm has a higher win rate and reward in confrontation,and the use of weapon resources is more efficient.It shows that the model and algorithm have certain superiority and rationality.The results of this paper provide new ideas for solving the problemof weapon-target assignment in air defense combat command decisions. | Tengda Li Gang Wang Qiang Fu Xiangke Guo Minrui Zhao Xiangyu Liu | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
| 9 | Fixed-Time and Predefined-Time Stability of Impulsive Systems显示文摘Dear Editor,This letter establishes several criteria for fixed-time stability and predefined-time stability of impulsive systems.First,sufficient conditions for fixed-time stability of impulsive systems are presented to treat the destabilizing impulses and hybrid impulses involving multiple jump maps by fixed-time control without linear feedback regulation.It determines the robustness of nonlinear systems against impulsive disturbance which has destabilizing and hybrid effect to dynamics. | Tengda Wei Xiaodi Li | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，4： | 0 |
| 10 | Mechanism of Wumei Pill in the Treatment of Non-Erosive reflux disease from the Perspective of Network Pharmacology and Molecular docking显示文摘Objective:Based on network pharmacology and molecular docking to explore the mechanism of Wumei Pill in the treatment of non-erosive reflux disease(NERD).Method:We collected the active ingredients and targets of Wumei Pill by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and collected NERD related targets through Genecards,PharmGKB,Drugbank,DisGeNET,OMIM,CTD and TTD databases.Intersection targets of Wumei Pill targets and NERD related targets were the potential targets of Wumei Pill in the treatment of NERD.We imported the intersection targets into the STRING database to obtain the PPI network,and obtained the hub targets.The network diagram of'Drugs-Potential active ingredients-Potential targets'was constructed by Cytoscape 3.7.2 software.We used R software to perform Gene Ontology function enrichment analysis(GO)and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis(KEGG)on hub targets,and then performed molecular docking verification.Results:There were 129 active ingredients and 213 drug targets of Wumei Pill of which 114 were the intersection targets.1587 GO enrichment items were identified(P<0.05),including 1,491 biological processes,11 cell components,and 85 molecular functions.143 KEGG pathways(P<0.05),mainly related to Kaposi sarcoma-associated herpesvirus infection,IL-17 signaling pathway,the TNF signaling pathway,MAPK signaling pathway.Results of molecular docking showed that the potential active ingredients in Wumei Pill had relatively stable binding activity to the key targets.Conclusion:Wumei pill for the treatment of non-erosive reflux disease are main active ingredients quercetin,kaempferol,beta sitosterol,Isocorypalmine,Stigmasterol,rutaecarpine,etc,the main targets is JUN,TP53,AKT1,may inhibit excessive inflammation,antioxidant therapy effect into full play.This provided a certain theoretical basis for clinical application. | Yihua Fan Tengda Li Rui Gong Wen Zhang Fenghua Yu Xinju Li | 2021 | Asian Toxicology Tesearch2021，3，4： | 0 |
| 11 | Based on network pharmacology to explore the mechanism of hepatotoxicity of Fructus Meliae Toosendan显示文摘Objective:To explore the potential mechanism of hepatotoxicity induced by Fructus Meliae Toosendan(FMT)through network pharmacology.Methods:The active components and targets of FMT were identified and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform Database,PubChem Database and Swiss Target Prediction database,etc.Genecards,pharmGKB,and OMIM databases were used to collect relevant targets of hepatotoxicity,and intersect them with the targets of active ingredients to obtain the potential targets of hepatotoxicity caused by FMT.A compound-target network was constructed with Cytoscape 3.8.0 software.The String 11.0 database was used to construct the protein-protein interaction(PPI)network of the targets and to screen out the core targets.In addition,Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were conducted by R software,and then the pathways directly related to hepatotoxicity were integrated.Results:In this study,9 active ingredients of FMT and 265 targets were obtained.There are 533 hepatotoxicity-related targets,and 76 potential targets for hepatotoxicity caused by FMT,among which quercetin,melianone,and nimbolin A are the key active components for hepatotoxicity caused by FMT,and MYC,STAT3,JUN,and RELA were the core target proteins of FMT’s hepatotoxicity.There were 2353 GO entries(P<0.05),including 2181 Biological Process(BP),41 Cellular Component(CC)and 131 Molecular Function(MF).KEGG enrichment analysis revealed 165 pathways(P<0.05),of which Th17 cell differentiation,HIF-1 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the hepatotoxicity of FMT.Conclusion:Through network pharmacology,it was found that many potential components in azadirachia chinaberry may be involved in the regulation of apoptosis,excessive inflammatory response and mitochondrial dynamics through multi-target and multi-pathway,resulting in the generation of hepatotoxicity. | Liting Wu Tengda Li Yu Zhang Lihui Yang Rongjin Yang Handong Liu | 2021 | Asian Toxicology Tesearch2021，3，4： | 0 |
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