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| 1 | Cu^(Ⅱ)-loaded polydopaminecoatingswith in situ nitric oxidegenerationfunctionforimproved hemocompatibility显示文摘NO is the earliest discovered gas signal molecule which is produced by normal healthy endothelial cells,and it has many functions,such as maintaining cardiovascular homeostasis,regulating vasodilation,inhibiting intimal hyperplasia and preventing atherosclerosis in the blood system.Insufficient NO release is often observed in the pathological environment,for instance atherosclerosis.It was discovered that NO could be released from the human endogenous NO donor by many compounds,and these methods can be used for the treatment of certain diseases in the blood system.In this work,a series of copper-loaded polydopamine(PDA)coatings were produced through self-polymerization time for 24,48 and 72 h.The chemical composition and structure,coating thickness and hydrophilicity of the different copper-loaded PDA coatings surfaces were characterized by phenol hydroxyl quantitative,X-ray photoelectron spectroscopy,ellipsometry atomic force microscopy and water contact angles.The results indicate that the thickness and the surface phenolic hydroxyl density of the PDA coatings increased with the polymerization time.This copperloaded coating has glutathione peroxidase-like activity,and it has the capability of catalyzing NO releasing from GSNO.The surface of the coating showed desirable hemocompatibility,the adhesion and activation of platelets were inhibited on the copper-loaded coatings.At the same time,the formation of the thrombosis was also suppressed.These copper-loaded PDA coatings could provide a promising platform for the development of blood contact materials. | Lei Zhou Xin Li Kebing Wang Fangyu Shen Lu Zhang Peichuang Li Tengda Shang Jin Wang Nan Huang | 2020 | Regenerative Biomaterials2020，7，2： | 0 |
| 2 | Improved corrosion resistance and biocompatibility of biomedical magnesium alloy with polypeptide TK14 functionalised hydrophobic coating显示文摘Magnesium(Mg)and its alloys can be used as biomedical materials because of their excellent mechanical properties and biocompatibility.However,the rapid degradation rate of Mg-based materials limits their application in biodegradable intravascular stents.To overcome this issue,we constructed a hydrophobic coating on magnesium.After pre-treatments with alkali and a silane coupling agent of pure magnesium,4,4’-diphenyl-methane-diisocyanate(MDI)and amino-terminated polydimethylsiloxane(H_(2)N-PDMS-NH_(2))were stepwise deposited on the surface,forming an amino-containing hydrophobic coating(-(M/P)_(3))to enhance the corrosion resistance.Furthermore,polypeptide TK14 was immobilised on the hydrophobic coating to promote vascular endothelial cell adhesion and proliferation.The electrochemical results revealed that the self-corrosion current density(i_(corr))of-(M/P)_(3) decreased by approximately 4.5 orders of magnitude compared with that of pure Mg.After TK14 immobilisation,the number of endothelial cells adhering to the surface of-(M/P)_(3)-T increased significantly.Although the corrosion resistance of-(M/P)_(3)-T was slightly reduced,the subcutaneous implantation inflam-matory response of the surrounding tissues was lower,showing suitable biocompatibility.Therefore,the polypeptide TK14 functionalised hydrophobic coating may be a promising candidate material for the interface of magnesium-based cardiovascular implants. | Yang Shen Xiaolong Shen Hao Zhang Xin Li Tengda Shang Yuancong Zhao Jin Wang Nan Huang | 2021 | Biosurface and Biotribology2021，7，1： | 0 |
| 3 | Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality显示文摘Many polyurethanes(PUs)are blood-contacting materials due to their good mechanical properties,fatigue resistance,cytocompatibility,biosafety,and relatively good hemocompatibility.Further functionalization of the PUs using chemical synthetic methods is especially attractive for expanding their applications.Herein,a series of catechol functionalized PU(CPU-PTMEG)elastomers containing variable molecular weight of polytetramethylene ether glycol(PTMEG)soft segment are reported by stepwise polymerization and further introduction of catechol.Tailoring the molecular weight of PTMEG fragment enables a regulable catechol content,mobility of the chain segment,hydrogen bond and microphase separation of the C-PUPTMEG elastomers,thus offering tunability of mechanical strength(such as breaking strength from 1.3 MPa to 5.7 MPa),adhesion,self-healing eficiency(from 14.9%to 96.7%within 2 hours),anticoagulant,antioxidation,anti-inflammatory properties and cellular growth behavior.As cardiovascular stent coatings,the C-PU-PTMEGs demonstrate enough flexibility to withstand deformation during the balloon dilation procedure.Of special importance is that the C-PU-PTMEG-coated surfaces show the ability to rapidly scavenge free radicals to maintain normal growth of endothelial cells,inhibit smooth muscle cell proliferation,mediate inflammatory response,and reduce thrombus formation.With the universality of surface adhesion and tunable multifunctionality,these novel C-PU-PTMEG elastomers should find potential usage in artificial heart valves and surface engineering of stents. | Lei Zhou Lu Zhang Peichuang Li Manfred F.Maitz Kebing Wang Tengda Shang Sheng Dai Yudie Fu Yuancong Zhao Zhilu Yang Jin Wang Xin Li | 2023 | Research2023，，1： | 0 |
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