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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | Prevalence of osteoporotic vertebral fracture among community-dwelling elderly in Shanghai显示文摘To the Editor:Osteoporosis is becoming a common,serious,and costly health problem,which causes over nine million fractures annually worldwide.[1] Currently,osteoporotic fractures are a considerable burden to public health services and have fairly high morbidity and mortality.[2] Vertebral fractures are the most common osteoporotic fracture and may lead to a high risk of further fracture and could be prevalent in both females and males.[3] Ling et al[4] and Ms.OS studies[5] evaluated the prevalence of vertebral fractures in Beijing and Hong Kong,respectively.However,our knowledge of the descriptive epidemiology and risk factors for vertebral fracture in China still remains poor. | Chao Gao Yang Xu Li Li Wen-Qin Gu Chun-Tao Yi Qiong Zhu Hong-An Gu Bi-Hua Chen Qing-Qing Wang Feng Tang Ju-Liang Xu Jian-Miao Hou Hui-Jiang Song Hui Wang Zhi-Liang Wang Zhen-Lin Zhang | 2019 | Chinese Medical Journal2019，，14： | 31 |
| 4 | Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia显示文摘Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier.However,despite 16 years of research on a number of central nervous system disorders,an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme.Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system.To validate this technique,rats were subjected to a single intracranial (at the caudate nucleus),or intraperitoneal injection,of the compound citicoline,followed two hours later by a permanent middle cerebral artery occlusion (pMCAO).Results showed that 12 h after pMCAO,with 0.0025 g kg-1 citicoline,an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group.These results suggest that given the appropriate injection point,through SDD a pharmacologically effective concentration of citicoline can be administered. | HAN HongBin XIA ZuoLi CHEN He HOU Chao LI WeiBo | 2011 | Science China(Life Sciences)2011，54，3： | 24 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Hydroformylation of alkenes over rhodium supported on the metal-organic framework ZlF-8显示文摘 | Chao Hou Guofeng Zhao Yongjun Ji Zhiqiang Niu Dingsheng Wang Yadong Li | 2014 | Nano Research2014，7，9： | 18 |
| 7 | Progress of heat-hazard treatment in deep mines显示文摘在深煤矿把为深热的危险的控制技术基于,我们学习了国内外的深热的损坏和冷却技术的地位,总结了深热的危险的原因,分析并且比较热危险控制的紧急。结果证明深热的损坏的原因能被归因于三个方面,即,气候,地质并且采矿因素,地质的因素被认为为热危险的主要原因。也,我们比较了国内、海外的起源的很多种冷却技术,例如使使技术凉下来的技术,冰冷却技术和水凉下来的中央空调,与一种另外的冷却技术,即,使技术凉下来的 HEMS ,它与它的唯一的纯空气有大、重要的效果使技术凉下来,认识到从地下利用热资源到地面。这种技术使用秘密地获得的热;因此,技术能在煤矿支持低碳的环境经济开发,以便在中国完成低碳的煤生产。 | Yang Xiaojie Han Qiaoyun Pang Jiewen Shi Xiaowei Hou Dinggui Liu Chao | 2011 | Mining Science and Technology2011，21，2： | 15 |
| 8 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 9 | Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells显示文摘 | Li-li HOU Chao GAO Liang CHEN Guo-qiang HU Song-qiang XIE | 2013 | Acta Pharmacologica Sinica2013，34，11： | 11 |
| 10 | Microporous bamboo biochar for lithium-sulfur batteries显示文摘简单、便宜、可伸缩、环境地友好,多微孔的生物资源 biochars 在锂硫(Li-S ) 为申请一直在吸引热心注意电池。此处,多孔的竹子 biochar 经由创造多微孔的结构的一个 KOH/annealing 过程被激活,增加表面区域并且提高电子电导率。对待的样品被用来包含硫准备多微孔的竹子碳硫(英国计算机学会) 用作为 Li-S 电池的阴极的 nanocomposite 第一次。有 50 wt.% 硫内容的英国计算机学会 nanocomposite 交付 1,295 妈的一个高起始的能力 ??? ?? | Xingxing Gu Yazhou Wang Chao Lai Jingxia Qiu Sheng Li Yanglong Hou Wayde Martens Nasir Mahmood Shanqing Zhang | 2015 | Nano Research2015，8，1： | 11 |
| 11 | Late Mesozoic Ore-forming Events in the Ningwu Ore District, Middle-Lower Yangtze River Polymetallic Ore Belt, East China: Evidence from Zircon U-Pb Geochronology and Hf Isotopic Compositions of the Granodioritic Stocks显示文摘Late Mesozoic volcanic-subvolcanic rocks and related iron deposits, known as porphyry iron deposits in China, are widespread in the Ningwu ore district (Cretaceous basin) of the middle-lower Yangtze River polymetallic ore belt, East China. Two types of Late Mesozoic magmatic rocks are exposed: one is dioritic rocks closely related to iron mineralization as the hosted rock, and the other one is granodioritic (-granitic) rocks that cut the ore bodies. To understand the age of the iron mineralization and the ore-forming event, detailed zircon U-Pb dating and Hf isotope measurement were performed on granodioritic stocks in the Washan, Gaocun-Nanshan, Dongshan and Heshangqiao iron deposits in the basin. Four emplacement and crystallization (typically for zircons) ages of granodioritic rocks were measured as 126.1±0.5 Ma, 126.8±0.5 Ma, 127.3±0.5 Ma and 126.3±0.4 Ma, respectively in these four deposits, with the LA-MC-ICP-MS zircon U-Pb method. Based on the above results combined with previous dating, it is inferred that the iron deposits in the Ningwu Cretaceous basin occurred in a very short period of 131-127 Ma. In situ zircon Hf compositions of εHf(t) of the granodiorite are mainly from -3 to -8 and their corresponding 176Hf/177Hf ratio are from 0.28245 to 0.28265, indicating similar characteristics of dioritic rocks in the basin. We infer that granodioritic rocks occurring in the Ningwu ore district have an original relationship with dioritic rocks. These new results provide significant evidence for further study of this ore district so as to understand the ore-forming event in the study area. | DUAN Chao LI Yanhe HOU Kejun YUAN Shunda LIU Jialin ZHANG Cheng | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 11 |
| 12 | A stability study of goaf based on mechanical properties degradation of rock caused by rheological and disturbing loads显示文摘Based on the classical static theory and static numerical simulation,the static method could not accurately reflect the stability of goaf where the rocks on the pillar and roof are influenced by Theological and blasting disturbance for a long time.According to the test from the site,an experimental study was made in Theological and dynamic disturbance.After that,on the basis of variable rock mechanics parameters from the experimental data,numerical simulation was used to analyze the vertical stress distribution of goaf,vertical displacement and plastic area of roof in the 'deterioration' caused by Theological and blasting,which shows that the mechanics properties of the rock were greatly influenced by Theological,and dynamic disturbance.The results of the experimental study and numerical simulation show that the mechanics properties of rock are greatly influenced by Theological and dynamic disturbance.As a result,the stability of goaf is greatly reduced.Finally,by comparing golf monitoring results with the analysis of theoretical calculation,it was found that the results were approximately the same,which testifies the reliability of the method.This method provides a new way of studying the stability of goaf as well as laying a basic foundation for future safety management. | Xiao Chao Zheng Huaichang Hou Xiaolin Zhang Xiaojun | 2015 | International Journal of Mining Science and Technology2015，25，5： | 10 |
| 13 | Crack monitoring method based on Cu coating sensor and electrical potential technique for metal structure显示文摘Advanced crack monitoring technique is the cornerstone of aircraft structural health monitoring.To achieve real-time crack monitoring of aircraft metal structures in the course of service,a new crack monitoring method is proposed based on Cu coating sensor and electrical potential difference principle.Firstly,insulation treatment process was used to prepare a dielectric layer on structural substrate,such as an anodizing layer on 2A12-T4 aluminum alloy substrate,and then a Cu coating crack monitoring sensor was deposited on the structure fatigue critical parts by pulsed bias arc ion plating technology.Secondly,the damage consistency of the Cu coating sensor and2A12-T4 aluminum alloy substrate was investigated by static tensile experiment and fatigue test.The results show that strain values of the coating sensor and the 2A12-T4 aluminum alloy substrate measured by strain gauges are highly coincident in static tensile experiment and the sensor has excellent fatigue damage consistency with the substrate.Thirdly,the fatigue performance discrepancy between samples with the coating sensor and original samples was investigated.The result shows that there is no obvious negative influence on the fatigue performance of the 2A12-T4 aluminum alloy after preparing the Cu coating sensor on its surface.Finally,crack monitoring experiment was carried out with the Cu coating sensor.The experimental results indicate that the sensor is sensitive to crack,and crack origination and propagation can be monitored effectively through analyzing the change of electrical potential values of the coating sensor. | Hou Bo He Yuting Cui Ronghong Gao Chao Zhang Teng | 2015 | Chinese Journal of Aeronautics2015，28，3： | 10 |
| 14 | Prostate cancer antigen 3 moderately improves diagnostic accuracy in Chinese patients undergoing first prostate biopsy显示文摘(PCA3 ) 前列腺癌症抗原 3 是为诊断在白种人人口识别的前列腺癌症(PCa ) 的 biomarker。我们在在经历起始的前列腺活体检视的 500 个人预言活体检视结果评估了尿 PCA3 的有效性。PCA3 分数的预兆的力量在操作特征(巨鸟) 曲线(AUC ) 的接收装置下面并且由决定曲线分析由区域被评估。PCA3 分数足够了区别从否定前列腺活体检视结果积极但是没与 PCa 的攻击性被相关。巨鸟分析比 % fPSA 为 PCA3 分数显示出更高的 AUC (0.750 对 0.622, P = 0.046 ) 在有 4.0-10.0 ng 的 PSA 的病人, ml-1,而是基于 PCA3 的模型不比基础模型显著地好。决定曲线分析显示基于 PCA3 的模型比有为几乎所有阀值可能性的一个更高的网络好处的基础模型优异,在有 4.0-10.0 ng ml-1 的 PSA 的病人的 25%-40% 的特别阀值可能性。然而, PCA3 分数(0.712 ) 的 AUC 不在有 PSA 的病人比 % fPSA (0.698 ) 或 PSAD (0.773 ) 优异 > 10.0 ng ml-1。我们的结果证实 RT-PCR-based PCA3 测试中等在与 4.0-10.0 ng ml-1 的 PSA 经历第一前列腺活体检视的中国病人改进了诊断精确性。 | Fu-Bo Wang Rui Chen Shan-Cheng Ren Xiao-Lei Shi Ya-Sheng Zhu Wei Zhang Tai-Le Jing Chao Zhang Xu Gao Jian-Guo Hou Chuan-Liang Xu Ying-Hao Sun | 2017 | Asian Journal of Andrology2017，19，2： | 10 |
| 15 | LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan显示文摘We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope (GSJT, formerly called the Large sky Area Multi-Object fiber Spectroscopic Telescope - LAMOST). The survey will obtain spectra for 2.5 million stars brighter than r < 19 during dark/grey time, and 5 million stars brighter than r < 17 or J < 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope's design constrains the optimal declination range for observations to 10 < δ < 50 , and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies: disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration (LEGUE) survey will be completed in summer 2012, after a review of the results of the pilot survey. | Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. Beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang Fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu | 2012 | Research in Astronomy and Astrophysics2012，12，7： | 10 |
| 16 | Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects显示文摘For large segmental bone defects,porous titanium scaffolds have some advantages,however,they lack electrical activity which hinders their further use.In this study,a barium titanate(BaTiO3)piezoelectric ceramic was used to modify the surface of a porous Ti6Al4V scaffold(pTi),which was characterized by scanning electron microscopy,energy dispersive spectroscopy,X-ray photoelectron spectroscopy,and roughness and water contact angle analyses.Low intensity pulsed ultrasound(LIPUS)was applied in vitro and in vivo study.The activity of bone marrow mesenchymal stem cells,including adhesion,proliferation,and gene expression,was significantly superior in the BaTiO3/pTi,pTi+LIPUS,and BaTiO3/pTi+LIPUS groups than in the pTi group.The activity was also higher in the BaTiO3/pTi+LIPUS group than in the BaTiO3/pTi and pTi+LIPUS groups.Additionally,micro-computed tomography,the mineral apposition rate,histomorphology,and the peak pull-out load showed that these scaffold conditions significantly enhanced osteogenesis and osseointegration 6 and 12 weeks after implantation in large segmental bone defects in the radius of rabbits compared with those resulting from the pTi condition.Consequently,the improved osteogenesis and osseointegration make the BaTiO3/pTi+LIPUS a promising method to promote bone regeneration in large segmental bone defects for clinical application. | Bo Fan Zheng Guo Xiaokang Li Songkai Li Peng Gao Xin Xiao Jie Wu Chao Shen Yilai Jiao Wentao Hou | 2020 | Bioactive Materials2020，5，4： | 9 |
| 17 | The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala显示文摘The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 18 | The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST's special design allows both a large aperture (effective aperture of 3.6 m-4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror's surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects. | Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping Li Qi Li Li-Ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-Li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-Hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-Hong Tang Qing-Sheng Tao Xiang-Yan Yuan Chao Zhai Jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 8 |
| 19 | rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner显示文摘Allorejection 为成功的机关移植仍然是一个障碍。尽管抑制免疫力的代理人的不同类型为控制拒绝并且延长接枝幸存是有效的,因为副作用和毒性,药治疗被限制。因此,为导致 allotolerance 识别新候选人药必要、迫切。最近,细菌的 flagellin 在 vitro 在人导致规章的 T 房间(Tregs ) 的抑制免疫力的活动,这被报导了。在现在的学习,我们在 allograft 幸存上分析了 recombinant flagellin (rFliC ) 的效果并且探索了在一个鼠科的皮肤 allotransplantation 模型与接受者 Tregs 的激活联系的内在的机制。结果显示出那个 rFliC 政府(3mg/kg 每为 3 天的天, i.p ) 延长 allograft 幸存(吝啬的幸存时间:18.4 ± 1.1days ) 与控制组相比(10 ± 0.7days, P< 0.01 ) 。另外,像使用费的受体的更高积极的表示(TLR5 ) 5 在与 rFliC 管理的 allograft 以内被检测。CD4 + CD25 + Foxp3 + Tregs;Treg 相关的因素 TLR5 的表示, Foxp3, TGF-β 1 并且 IL-10;并且 Tregs 的增长和抑制被增加与控制相比跟随 rFliC 管理。而且,忍耐相关的分子的增加的表示和 rFliC 导致的 Tregs 的增长被在 vivo 并且在 vitro 堵住抗体的 anti-TLR5 稀释。在结论, rFliC 管理延长 allografts 的幸存,它以一种 TLR5 依赖的方式与接受者 Tregs 的激活被联系。rFliC 可以是 anti-allorejection 治疗的一个新候选人。 | Jing Hao Chao Zhang Jing Song Guihua Hou | 2014 | Cellular & Molecular Immunology2014，11，2： | 7 |
| 20 | Carbon nanotubes prepared by anodic aluminum oxide template method显示文摘One of the most unique structural characteristics of carbon nanotubes(CNTs) differentiating from other carbon materials is their hollow nanochannles,which can be utilized for encapsulating and loading foreign matters.The anodic aluminum oxide(AAO) template technique enables the diameter,length,and cap structure control of the replicated CNTs,and thus shows advantages in pore structure control over the traditional CNT growth approaches.This review details the synthesis of CNTs with tunable diameter,length,wall thickness,and crystalline by using the AAO template method.The doping of heteroatoms and filling of foreign matters into AAO-CNTs are also addressed.Moreover,the main challenges and developing trends of the AAO template method are discussed. | HOU PengXiang LIU Chang SHI Chao CHENG HuiMing | 2012 | Chinese Science Bulletin2012，57，2： | 7 |
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