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| 1 | Late Mesozoic Tectonic Evolution of Southwestern Fujian Province,South China:Constraints from Magnetic Fabric,Zircon U-Pb Geochronology and Structural Deformation显示文摘A combined study of magnetic fabrics, zircon U-Pb geochronology and structural deformation was carried out for Late Paleozoic sedimentary and Mesozoic magmatic rocks in the southwestern Fujian rift basin, South China, aiming at deciphering the tectonic evolution during Late Mesozoic. Field observations showed that the Late Mesozoic structure deformations in southwestern Fujian were categorized into four phases: NW-SE compression, ENE-WSW extension, NNE-SSW compression and NNW-SSE extension, sequentially. Zircons picked out from Juzhou granite and WNW-trending diabase dykes showed complete crystal shapes and clear oscillatory zonings on their edges, and the U-Pb dating yielded ages of 132 and 141 Ma, respectively. The susceptibility ellipsoid magnitude parameters of the Juzhou granite are characterized by flaser type strain ellipsoid, with pole density center of K3 falling into the first and the third quadrants, these features revealed that the Juzhou granite formed in ENE-WSW compressional stress field, indicating the early stage of Early Cretaceous extrusion in southwestern Fujian. The late stage of Early Cretaceous NNE-SSW extension was limited by the widespread WNW-trending diabase dykes, which were usually regarded as important indications for a regional extensional setting. On the basic of the previous researches, structural deformation studies, and the deductions above, it can be concluded that southwestern Fujian experienced five main tectonic stages during Late Mesozoic: Early Jurassic extension, Middle–Late Jurassic thrusting, early stage of Early Cretaceous extension, late stage of Early Cretaceous compression and Late Cretaceous extension. | Sen Wang Da Zhang Ganguo Wu Xingjian Li Xiaoqiao Gao Absai Vatuva Yuan Yuan Tengda Yu Yu Bai Ye Fang | 2018 | Journal of Earth Science2018，29，2： | 4 |
| 2 | Autonomous orbit determination using epoch-differenced gravity gradients and starlight refraction显示文摘Autonomous orbit determination via integration of epoch-differenced gravity gradients and starlight refraction is proposed in this paper for low-Earth-orbiting satellites operating in GPSdenied environments. Starlight refraction compensates for the significant along-track position error that occurs from only using gravity gradients and benefits from integration in terms of improved accuracy in radial and cross-track position estimates. The between-epoch differencing of gravity gradients is employed to eliminate slowly varying measurement biases and noise near the orbit revolution frequency. The refraction angle measurements are directly used and its Jacobian matrix derived from an implicit observation equation. An information fusion filter based on a sequential extended Kalman filter is developed for the orbit determination. Truth-model simulations are used to test the performance of the algorithm, and the effects of differencing intervals and orbital heights are analyzed. A semi-simulation study using actual gravity gradient data from the Gravity field and steady-state Ocean Circulation Explorer(GOCE) combined with simulated starlight refraction measurements is further conducted, and a three-dimensional position accuracy of better than 100 m is achieved. | Pei CHEN Tengda SUN Xiucong SUN | 2017 | Chinese Journal of Aeronautics2017，30，5： | 4 |
| 3 | New Geochronologic Evidence of Diabases and Their Metallogenic Relationship with the Makeng-Type Iron Deposits in Southwest Fujian, SE China显示文摘Objective The Makeng-type iron deposits are located in Late Paleozoic depression of southwest Fujian Province in the southeast edge of Cathaysia,which are famous for their huge scale and specific ore genesis.Previous studies mainly focus on the ore characteristics,metallogenic setting and the granites in the mining area,and there is still controversy on the ore genesis.Recent research | WANG Sen ZHANG Da WU Ganguo CAO Ke QU Hongjie MA Shuai YU Tengda | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 3 |
| 4 | Factors Contributing to High Costs and Inequality in China's Health Care System显示文摘 | Hongli Wang Tengda Xu Jin Xu | 2007 | JAMA2007，298，16： | 1 |
| 5 | Factors Contributing to High Costs and Inequality in China's Health Care System显示文摘 | Hongli Wang Tengda Xu Jin Xu | 2007 | JAMA2007，298，16： | 1 |
| 6 | Clinical decision-making by the emergency department resident physicians for critically ill patients显示文摘The application of main methodologies for clinical decision-making by residents in emergency medical practice was assessed,and issues in this area were investigated.The treatments provided to 2611 critical patients by the Emergency Department of Peking Union Medical College Hospital were analyzed by independent investigators who evaluated the main clinical decision-making processes applied by the hospital residents.The application of decision-making strategies by PG1 and PG3 groups,which means the residents in first year and the third year,were compared.The patients were treated according to pattern recognition(43.0%),hypotheticodeductive reasoning(23.4%),event-driven models(19.3%),and rule-using algorithms(5.9%).A significant difference was found between PG1 and PG3 groups(χ^(2)=498.01,P<0.001).Pattern recognition and hypotheticdeductive methods were the most common techniques applied by emergency physicians in evaluating critically ill patients.The decision-making processes applied by junior and senior residents were significantly different,although neither group adequately applied rule-using algorithms.Inclusion of clinical decision-making in medical curricula is needed to improve decision-making in critical care. | Tengda Xu Jun Xu Xuezhong Yu Sui Ma Zhong Wang | 2012 | Frontiers of Medicine2012，6，1： | 1 |
| 7 | Fusobacterium nucleatum:a new player in regulation of cancer development and therapeutic response显示文摘A dysbiosis in microbial diversity or functionality can promote disease development.Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment response of different cancers.One bacterium that has garnered much attention in a few cancer microbiota studies is Fusobacterium nucleaum(Fn).To provide updated knowledge of the functional role of Fn in cancer prevention and management,this review summarizes the relationship among Fn,cancer,and chemoimmunotherapy response,with the potential mechanisms of action also intensively discussed,which will benefit the development of strategies to prevent or treat cancer via Fn-based therapeutic interventions. | Tengda Zhao Xueping Wang Liwu Fu Ke Yang | 2022 | Cancer Drug Resistance2022，5，2： | 1 |
| 8 | Early recognition of myxedematous respiratory failure in the elderly显示文摘 | Fuping Guo Tengda Xu Houli Wang | 2009 | American Journal of Emergency Medicine2009，，2： | 1 |
| 9 | Ligand-free nickel-catalyzed Kumada couplings of aryl, bromides with tert-butyl Grignard reagents显示文摘A ligand-free nickel-catalyzed Kumada cross-coupling of aryl bromides and tert-butyl Grignard reagents led to the formation of a series of tert-butyl aryls in moderate to good yields, excellent tBu/iBu ratios, and good functional group compatibility. A radical coupling process is indicated and a mechanism with a Ni(Ⅰ)-Ni(Ⅲ) catalytic cycle is proposed. | Zhenghan Wu Tengda Si Guangqing Xu Bin Xu Wenjun Tang | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
| 10 | Gallstones in liver transplant recipients:A single-center study in China显示文摘 | Shi R Shen ZY Tengda H et | 2015 | Turk J Gastroenterol2015，26，5： | 1 |
| 11 | Implanting iodine-125 seeds into rat dorsal root ganglion for neuropathic pain: neuronal microdamage without impacting hind limb motion显示文摘The use of iodine-125(125I) in cancer treatment has been shown to relieve patients' pain. Considering dorsal root ganglia are critical for neural transmission between the peripheral and central nervous systems, we assumed that 125 I could be implanted into rat dorsal root ganglia to provide relief for neuropathic pain. 125 I seeds with different radioactivity(0, 14.8, 29.6 MBq) were implanted separately through L4–5 and L5–6 intervertebral foramen into the vicinity of the L5 dorsal root ganglion. von Frey hair results demonstrated the mechanical pain threshold was elevated after implanting 125 I seeds from the high radioactivity group. Transmission electron microscopy revealed that nuclear membrane shrinkage, nucleolar margination, widespread mitochondrial swelling, partial vacuolization, lysosome increase, and partial endoplasmic reticulum dilation were visible at 1,440 hours in the low radioactivity group and at 336 hours in the high radioactivity group. Abundant nuclear membrane shrinkage, partial fuzzy nuclear membrane and endoplasmic reticulum necrosis were observed at 1,440 hours in the high radioactivity group. No significant difference in combined behavioral scores was detected between preoperation and postoperation in the low and high radioactivity groups. These results suggested that the mechanical pain threshold was elevated after implanting 125 I seeds without influencing motor functions of the hind limb, although cell injury was present. | Ling Jiao Tengda Zhang Huixing Wang Wenyi Zhang Saijun Fan Xiaodong Huo Baosen Zheng Wenting Ma | 2014 | Neural Regeneration Research2014，9，12： | 1 |
| 12 | Factors Contributing to High Costs and Inequality in China's Health Care System 显示文摘 | Hongli Wang Tengda Xu Jin Xu | 2007 | JAMA2007，298，16： | 1 |
| 13 | Cu^(Ⅱ)-loaded polydopaminecoatingswith in situ nitric oxidegenerationfunctionforimproved hemocompatibility显示文摘NO is the earliest discovered gas signal molecule which is produced by normal healthy endothelial cells,and it has many functions,such as maintaining cardiovascular homeostasis,regulating vasodilation,inhibiting intimal hyperplasia and preventing atherosclerosis in the blood system.Insufficient NO release is often observed in the pathological environment,for instance atherosclerosis.It was discovered that NO could be released from the human endogenous NO donor by many compounds,and these methods can be used for the treatment of certain diseases in the blood system.In this work,a series of copper-loaded polydopamine(PDA)coatings were produced through self-polymerization time for 24,48 and 72 h.The chemical composition and structure,coating thickness and hydrophilicity of the different copper-loaded PDA coatings surfaces were characterized by phenol hydroxyl quantitative,X-ray photoelectron spectroscopy,ellipsometry atomic force microscopy and water contact angles.The results indicate that the thickness and the surface phenolic hydroxyl density of the PDA coatings increased with the polymerization time.This copperloaded coating has glutathione peroxidase-like activity,and it has the capability of catalyzing NO releasing from GSNO.The surface of the coating showed desirable hemocompatibility,the adhesion and activation of platelets were inhibited on the copper-loaded coatings.At the same time,the formation of the thrombosis was also suppressed.These copper-loaded PDA coatings could provide a promising platform for the development of blood contact materials. | Lei Zhou Xin Li Kebing Wang Fangyu Shen Lu Zhang Peichuang Li Tengda Shang Jin Wang Nan Huang | 2020 | Regenerative Biomaterials2020，7，2： | 0 |
| 14 | Based on network pharmacology to explore the mechanism of nephrotoxicity of Xanthii Fructus显示文摘Objective:To explore the potential mechanism of nephrotoxicity induced by Xanthii Fructus(XF)through network pharmacology.Methods:The active ingredients and targets of XF were screened through Traditional Chinese Medicine Systems Pharmacology Database,PubChem Database and Swiss Target Prediction Database,and the related pathogenic genes of nephrotoxicity were downloaded from Genecards,pharmGKB and OMIM databases.The potential target is the intersection of XF and the pathogenic gene of nephrotoxicity.Cytoscape software was used to construct a network of“XF-Potential active ingredient-Target-Nephrotoxicity network”.Protein protein interaction(PPI)network was constructed by String database,and the data was analyzed and sorted out to obtain the key active components and core target proteins of XF.GO functional enrichment analysis and KEGG pathway enrichment analysis of key target proteins were performed by R software.Results:11 active components,167 targets,6839 nephrotoxicity related pathogenic genes and 139 intersection target genes were screened from XF.After constructing the network of“XF-Potential active ingredient-target-nephrotoxicity network”and PPI network,the key active ingredients of XF were identified as Moupinamide,Beta-sitosterol and Stigmasterol,and the core target proteins were CASP3,HSP90AA1 and TP53.There were 2072 GO entries(P<0.05),including 1876 Biological Process(BP),64 Cellular Component(CC)and 132 Molecular Function(MF).KEGG enrichment analysis revealed 138 pathways(P<0.05),mainly involving p53 signaling pathway,IL-17 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the nephrotoxicity of XF.Conclusion:The core target protein of XF HSP90AA1,CASP3 and TP53 participate in p53 signaling Pathway,PI3K-Akt signaling Pathway,IL-17 signaling Pathway and other pathways to regulate apoptosis and induce inflammatory responses,resulting in kidney damage. | Tao Chen Tengda Li Wenna Zhang Yulin Song Yuman Tang Rui Gong Hua Jin | 2022 | Asian Toxicology Tesearch2022，4，1： | 0 |
| 15 | Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo显示文摘Photobiomodulation(PBM)promoting wound healing has been demonstrated by many studies.Currently,630 nm and 810 nm light-emitting diodes(LEDs),as light sources,are frequently used in the treatment of diabetic foot ulcers(DFUs)in clinics.However,the dose-effect relationship of LED-mediated PBM is not fully understood.Furthermore,among the 630 nm and 810 nm LEDs,which one gets a better effect on accelerating the wound healing of diabetic ulcers is not clear.The aim of this study is to evaluate and compare the effects of 630 nm and 810 nm LED-mediated PBM in wound healing both in vitro and in vivo.Our results showed that both 630 nm and 810 nm LED irradiation significantly promoted the proliferation of mouse fibroblast cells(L929)at different light irradiances(1,5,and 10 mW/cm^(2)).The cell proliferation rate increased with the extension of irradiation time(100,200,and 500 s),but it decreased when the irradiation time was over 500 s.Both 630 nm and 810nm LED irradiation(5 mW/cm^(2))significantly improved the migration capability of L929 cells.No difference between 630 nm and 810 nm LED-mediated PBM in promoting cell proliferation and migration was detected.In vivo results presented that both 630 nm and 810 nm LED irradiation promoted the wound healing and the expression of the vascular endothelial growth factor(VEGF)and transforming growth factor(TGF)in the wounded skin of type 2 diabetic mice.Overall,these results suggested that LED-mediated PBM promotes wound healing of diabetic mice through promoting fibroblast cell proliferation,migration,and the expression of growth factors in the wounded skin.LEDs(630 nm and 810 nm)have a similar outcome in promoting wound healing of type 2 diabetic mice. | Hongyou Zhao Tengda Ji Tianzhen Sun Haolin Liu Yidi Liu Defu Chen Ying Wang Yizhou Tan Jing Zeng Haixia Qiu Ying Gu | 2022 | Journal of Innovative Optical Health Sciences2022，15，2： | 0 |
| 16 | Compositional characteristics and toxicological responses of human lung epithelial cells to inhalable particles (PM_(10)) from ten typical biomass fuel combustions显示文摘As the primary component of haze,atmospheric inhalable particulate matters(PMio)are highly detri-mental to human health.Biomass combustion is one of China's most pivotal sources to aerosols pollution,inducing non-negligible emissions and uncertain risks.PMio samples directly from 10 representative biomass fuel combustion sources(2 groups covering the reality widely:straws of rice,wheat,corn,corncob,soybean,peanut,rape,sesame;and branches of pine,peach)were collected using the dilution channel sampler and analyzed for chemical compositions and in vitro cytotoxicity to human lung epithelial cell lines A549.The components of PMio are dominated by organic carbon(OC),followed by Water-soluble K+and Cl,and rich in metals Fe,Zn,Cr,and Ni.Generally,PMio emitted from biomass fuel combustions can weaken the antioxidant capacity of cells,and straws emissions,especially rape and peanut straws,show stronger ability to further induce oxidative stress and inflammatory damage than fuelwoods,owing to the key toxic roles of Cr,Ni,and Co.Therefore,reducing the specific source emis--sions of PMio from crop straw combustions rich in heavy metals could be an effective oriented strategy to improve environmental air quality and control aerosols pollution precisely for protecting public health. | Hanhan Li Mingwei Tang Xiaosan Luo Weijun Li Yuting Pang Weijie Huang Zhen Zhao Yaqian Wei Tengda Long Tariq Mehmood | 2023 | Particuology2023，，7： | 0 |
| 17 | Improved corrosion resistance and biocompatibility of biomedical magnesium alloy with polypeptide TK14 functionalised hydrophobic coating显示文摘Magnesium(Mg)and its alloys can be used as biomedical materials because of their excellent mechanical properties and biocompatibility.However,the rapid degradation rate of Mg-based materials limits their application in biodegradable intravascular stents.To overcome this issue,we constructed a hydrophobic coating on magnesium.After pre-treatments with alkali and a silane coupling agent of pure magnesium,4,4’-diphenyl-methane-diisocyanate(MDI)and amino-terminated polydimethylsiloxane(H_(2)N-PDMS-NH_(2))were stepwise deposited on the surface,forming an amino-containing hydrophobic coating(-(M/P)_(3))to enhance the corrosion resistance.Furthermore,polypeptide TK14 was immobilised on the hydrophobic coating to promote vascular endothelial cell adhesion and proliferation.The electrochemical results revealed that the self-corrosion current density(i_(corr))of-(M/P)_(3) decreased by approximately 4.5 orders of magnitude compared with that of pure Mg.After TK14 immobilisation,the number of endothelial cells adhering to the surface of-(M/P)_(3)-T increased significantly.Although the corrosion resistance of-(M/P)_(3)-T was slightly reduced,the subcutaneous implantation inflam-matory response of the surrounding tissues was lower,showing suitable biocompatibility.Therefore,the polypeptide TK14 functionalised hydrophobic coating may be a promising candidate material for the interface of magnesium-based cardiovascular implants. | Yang Shen Xiaolong Shen Hao Zhang Xin Li Tengda Shang Yuancong Zhao Jin Wang Nan Huang | 2021 | Biosurface and Biotribology2021，7，1： | 0 |
| 18 | Fate of organophosphate esters from the Northwestern Pacific to the Southern Ocean:Occurrence,distribution,and fugacity model simulation显示文摘Eleven organophosphate esters(OPEs)in the air and seawater were investigated from the northwestern Pacific Ocean to the Southern Ocean during the 2018 Chinese 34th Antarctic Scientific Expedition.The concentration of total OPEs ranged from 164.82 to 3501.79 pg/m~3in air and from 4.54 to 70.09 ng/L in seawater.Two halogenated OPEs,tri(chloropropyl)phosphate(TCPP)and tri(2-chloroethyl)phosphate(TCEP),were generally more abundant than the non-halogenated OPEs.A levelⅢfugacity model was developed to simulate the transfer and fate of seven OPEs in the air and seawater regions of the central Ross Sea.The model results indicate that OPEs are transferred from the air to the seawater in the central Ross Sea in summer,during which the Ross Sea acts as a final OPE sink.Dry and wet deposition dominated the processes involving OPE transfer to seawater.The OPE degradation process was also found to be more pervasive in the atmosphere than in the seawater region.These findings highlights the importance of long-range transport of OPEs and their air–seawater interface behavior in the Antarctic. | Tengda Shi Ruijing Li Jie Fu Chao Hou Hui Gao Guanjie Cheng Haibo Zhang Shuaichen Jin Liang Kong Guangshui Na | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 19 | Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality显示文摘Many polyurethanes(PUs)are blood-contacting materials due to their good mechanical properties,fatigue resistance,cytocompatibility,biosafety,and relatively good hemocompatibility.Further functionalization of the PUs using chemical synthetic methods is especially attractive for expanding their applications.Herein,a series of catechol functionalized PU(CPU-PTMEG)elastomers containing variable molecular weight of polytetramethylene ether glycol(PTMEG)soft segment are reported by stepwise polymerization and further introduction of catechol.Tailoring the molecular weight of PTMEG fragment enables a regulable catechol content,mobility of the chain segment,hydrogen bond and microphase separation of the C-PUPTMEG elastomers,thus offering tunability of mechanical strength(such as breaking strength from 1.3 MPa to 5.7 MPa),adhesion,self-healing eficiency(from 14.9%to 96.7%within 2 hours),anticoagulant,antioxidation,anti-inflammatory properties and cellular growth behavior.As cardiovascular stent coatings,the C-PU-PTMEGs demonstrate enough flexibility to withstand deformation during the balloon dilation procedure.Of special importance is that the C-PU-PTMEG-coated surfaces show the ability to rapidly scavenge free radicals to maintain normal growth of endothelial cells,inhibit smooth muscle cell proliferation,mediate inflammatory response,and reduce thrombus formation.With the universality of surface adhesion and tunable multifunctionality,these novel C-PU-PTMEG elastomers should find potential usage in artificial heart valves and surface engineering of stents. | Lei Zhou Lu Zhang Peichuang Li Manfred F.Maitz Kebing Wang Tengda Shang Sheng Dai Yudie Fu Yuancong Zhao Zhilu Yang Jin Wang Xin Li | 2023 | Research2023，，1： | 0 |
| 20 | Early Warning and Monitoring of Coronavirus Disease 2019 Using Baidu Search Index and Baidu Information Index in Guangxi,China显示文摘Coronavirus disease 2019(COVID-19)is an emerging infectious disease,and it is important to detect early and monitor the disease trend for policymakers to make informed decisions.We explored the predictive utility of Baidu Search Index and Baidu Information Index for early warning of COVID-19 and identified search keywords for further monitoring of epidemic trends in Guangxi.A time-series analysis and Spearman correlation between the daily number of cases and both the Baidu Search Index and Baidu Information Index were performed for seven keywords related to COVID-19 from January 8 to March 9,2020.The time series showed that the temporal distributions of the search terms“coronavirus,”“pneumonia”and“mask”in the Baidu Search Index were consistent and had 2 to 3 days'lead time to the reported cases;the correlation coefficients were higher than 0.81.The Baidu Search Index volume in 14 prefectures of Guangxi was closely related with the number of reported cases;it was not associated with the local GDP.The Baidu Information Index search terms“coronavirus”and“pneumonia”were used as frequently as 192,405.0 and 110,488.6 per million population,respectively,and they were also significantly associated with the number of reported cases(rs>0.6),but they fluctuated more than for the Baidu Search Index and had 0 to 14 days'lag time to the reported cases.The Baidu Search Index with search terms“coronavirus,”“pneumonia”and“mask”can be used for early warning and monitoring of the epidemic trend of COVID-19 in Guangxi,with 2 to 3 days'lead time. | Yihong Xie Wanwan Zhou Jinhui Zhu Yuhua Ruan Xiaomin Wang Tengda Huang | 2022 | Infectious Microbes & Diseases2022，4，4： | 0 |
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