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| 1 | The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?显示文摘Macrophages are one of the most abundant leukocyte populations infiltrating tumor tissues and can exhibit both tumoricidal and tumor-promoting activities.In 1989,we reported the purification of monocyte chemoattractant protein-1(MCP-1)from culture supernatants of mitogen-activated peripheral blood mononuclear cells and tumor cells.MCP-1 is a potent monocyte-attracting chemokine,identical to the previously described lymphocyte-derived chemotactic factor or tumor-derived chemotactic factor,and greatly contributes to the recruitment of blood monocytes into sites of inflammatory responses and tumors.Because in vitro-cultured tumor cells often produce significant amounts of MCP-1,tumor cells are considered to be the main source of MCP-1.However,various nontumor cells in the tumor stroma also produce MCP-1 in response to stimuli.Studies performed in vitro and in vivo have provided evidence that MCP-1 production in tumors is a consequence of complex interactions between tumor cells and non-tumor cells and that both tumor cells and non-tumor cells contribute to the production of MCP-1.Although MCP-1 production was once considered to be a part of host defense against tumors,it is now believed to regulate the vicious cycle between tumor cells and macrophages that promotes the progression of tumors. | Teizo Yoshimura | 2018 | Cellular & Molecular Immunology2018，15，4： | 19 |
| 2 | Chemokines in homeostasis and diseases显示文摘For the past twenty years,chemokines have emerged as a family of critical mediators of cell migration during immune surveillance,development,inflammation and cancer progression.Chemokines bind to seven transmembrane G protein-coupled receptors(GPCRs)that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation.Although chemokines have evolved to benefit the host,inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases.Therefore,understanding the role of chemokines and their GPCRs in the complex physiological and diseased microenvironment is important for the identification of novel therapeutic targets.This review introduces the functional array and signals of multiple chemokine GPCRs in guiding leukocyte trafficking as well as their roles in homeostasis,inflammation,immune responses and cancer. | Keqiang Chen Zhiyao Bao Peng Tang Wanghua Gong Teizo Yoshimura Ji Ming Wang | 2018 | Cellular & Molecular Immunology2018，15，4： | 7 |
| 3 | IgG subclasses and complement pathway in segmental and global membranous nephropathy显示文摘 | Yoshie Segawa Satoshi Hisano Misao Matsushita Teizo Fujita Shinichi Hirose Morishige Takeshita Hiroshi Iwasaki | 2010 | Pediatric Nephrology2010，，： | 1 |
| 4 | Cytokine induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells显示文摘 | Teizo Yoshiumura Laura Tan | 1992 | J Immunol1992，148，： | 1 |
| 5 | Heparin accelerates liver regeneration following portal branch ligation in normal and cirrhotic rats with increased plasma hepatocyte growth factor levels显示文摘 | Teizo N Shigeki A Masayuki I | 2002 | Journal of Hepatology2002，37，： | 1 |
| 6 | Histidine decarboxylases and their role in accumulation of histamine in tuna and dried saury显示文摘 | MASASHI K TOMOKO Y TEIZO T | 2007 | Applied and Environmental Microbiology2007，73，5： | 1 |
| 7 | The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis显示文摘Breast cancer is the most prevalent cancer worldwide,and metastasis is the leading cause of death in cancer patients.Human monocyte chemoattractant protein-1(MCP-1/CCL2)was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human monocytes.MCP-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages(TAMs),and it became a candidate target of clinical intervention;however,the role of TAMs in cancer development was still controversial at the time of the discovery of MCP-1.The in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues,including breast cancers.Positive correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were established.The contribution of MCP-1 to the growth of primary tumors and metastasis to the lung,bone,and brain was examined in mouse breast cancer models.The results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not bone.Potential mechanisms of MCP-1 production in the breast cancer microenvironment have also been reported.In the present manuscript,we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis. | Teizo Yoshimura Chunning Li Yuze Wang Akihiro Matsukawa | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 8 | Klebsiella pneumoniae produces No histamine Raoultella planticola and Raoultella ornithinolytica strains histamine producers显示文摘 | Masashi K Tomoko Y Teizo T | 2002 | APPL Environ Microb2002，68，7： | 1 |
| 9 | Solvent-free coumarin synthesis 显示文摘 | TEIZO S KOICHI T | 2001 | Chem Lett2001，30，2： | 1 |
| 10 | Solvent-free coumarin synthesis 显示文摘 | Teizo S Koichi T | 2001 | Chem Lett2001，67，2： | 1 |
| 11 | Important Role of Local Angiotensin II Activity Mediated via Type 1 Receptor in the Pathogenesis of Cardiovascular Inflammatory Changes Induced by Chronic Blockade of Nitric Oxide Synthesis in Rats显示文摘 | Makoto Usui Kensuke Egashira Hideharu Tomita Masamichi Koyanagi Makoto Katoh Hiroaki Shimokawa Motohiro Takeya Teizo Yoshimura Kouji Matsushima Akira Takeshita | 2000 | Circulation: Journal of the American Heart Association2000，，3： | 1 |
| 12 | Analysis of the Inflammatroy Cytokine Network among TNF - α ,IL - Iβ, IL- 1 Receptor Antagonist , and IL- 8 in Lps- Induced Rabbit Arthritis显示文摘 | Akihiro Mastsukawa teizo Yoshimura Kazuhiko Miyamoto | 1997 | Laboratory Investigation1997，76，5： | 1 |
| 13 | Biochimica et CO binding study of mouse heme-regulated elF-2a kinase:kinetics and resonance Raman spectra 显示文摘 | Jotaro Igarashi Akira Sato Teizo Kitagawa | 2003 | Acta2003，1650，： | 1 |
| 14 | Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells显示文摘 | BARD H TEIZO Y LAURA T 4 N | 1992 | J lmmunol1992，148，： | 1 |
| 15 | Analysis of the Inflammatroy cytokine Network among TNF-α、IL-1β、IL-1 receptor antagonist and IL-8 in Lps-Induced rabbit arthritis 显示文摘 | Akihiro Mastsukawa Teizo Yoshimura Kazuhiko Miyamoto | 1997 | Laboratory Investigation1997，5，： | 1 |
| 16 | Kinetics of macrophage subpopulations and expression of monocyte chemoattractant prorein-1 (MCP-1) in bleomycin-induced lung injury of rats studied by a novel monoclonal antibody against rat MCP-1 显示文摘 | Yuji S Motohiro T Teizo Y | 1994 | J Leukoc Biol1994，56，6： | 1 |
| 17 | Human monocyte chemoattractant protein-1 (MCP-1) 显示文摘 | Edward J Leonard Teizo Yoshimura | 1990 | Immunology Today1990，1，3： | 1 |
| 18 | Klebsiella pneumo- niae produces no histamine: Raoultella planticola and Raoultella ornithinolytica strains are histamine producers 显示文摘 | Masashi K Tomoko Y Teizo T | 2002 | Applied and Environmental Microbiology2002，68，7： | 1 |
| 19 | Klebsiella pneumoniae produces No histamine:Raoultella planticola and Raoultella ornithinolytica strains are histamine producers显示文摘 | Masashi Kanki Tomoko Yoda Teizo Tsukamoto | 2002 | Appl Environ Microbiol2002，68，7： | 1 |
| 20 | Complement activation through the lectin pathway in patients with Henoch-Sch?nlein purpura nephritis显示文摘 | Morito Endo Hiroyuki Ohi Isao Ohsawa Takayuki Fujita Misao Matsushita Teizo Fujita | 2000 | American Journal of Kidney Diseases2000，，3： | 1 |
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