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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients显示文摘AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pan- creatic benign surgical diseases (n = 15, control group) were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS: CK-19 mRNA expression was increased in 24 (64%) blood samples and 11 (30%) of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3). Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancerpatients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocar- cinoma by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers. | Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller Joachim Thiery Johann Hauss Helmut Witzigmann | 2007 | World Journal of Gastroenterology2007，13，2： | 20 |
| 3 | Epithelial-Mesenchymal Transitions in Development and Disease显示文摘 | Jean Paul Thiery Hervé Acloque Ruby Y.J. Huang M. Angela Nieto | 2009 | Cell2009，，5： | 14 |
| 4 | Epithelial–mesenchymal transitions in development and pathologies显示文摘 | Jean Paul Thiery | 2003 | Current Opinion in Cell Biology2003，，6： | 4 |
| 5 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 6 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 7 | Epithelial-Mesenchymal Transitions in Development and Disease显示文摘 | Jean Paul Thiery Hervé Acloque Ruby Y.J. Huang M. Angela Nieto | 2009 | Cell2009，，5： | 2 |
| 8 | Tumor Dissemination: An EMT Affair显示文摘 | Jean Paul Thiery Chwee Teck Lim | 2013 | Cancer Cell2013，，3： | 2 |
| 9 | Epithelial-mesenchymal transitions in tumo-ur Progression显示文摘 | Thiery JP | 2002 | Nat Rev Cancer2002，2，： | 1 |
| 10 | Simvastatin reduces graft versel disease and mortality after heart transplantation: a four-year randomized trail显示文摘 | Wenke K Meiser B Thiery J | 1997 | Circulation1997，96，5： | 1 |
| 11 | FI'-IR measurements of petroleum fluid inclusions : Methane, n-alkanes, and carbon dioxide quantitative analysis 显示文摘 | Pironon J Thiery R Aytougougdal M Teinturier S Beaudoin G Walgenwitz F | 2001 | Geofluids2001，，1： | 1 |
| 12 | Complex networks orchestrate epithelial- mesenchymal transitions显示文摘 | Thiery JP Sleeman JP | 2006 | Nat Rev Mol Cell Biol2006，7，2： | 1 |
| 13 | Epithelial-mesenchymal transitions in tumourprogression显示文摘 | Thiery J P | 2002 | Nat Rev Cancer2002，2，6： | 1 |
| 14 | Fibroblast growth factor- 2显示文摘 | Okada- Ban M Thiery J-P Jouanneau J | 2000 | Int J Biochem2000，32，2： | 1 |
| 15 | Epithelial-mesenchymal tran- sitions in development and disease 显示文摘 | Thiery JP Acloque H Huang RY | 2009 | Cell2009，139，5： | 1 |
| 16 | The physiology and pathology of the EMT Meeting on the epithelial-mesenchymal transition 显示文摘 | Acloque H Thiery JP Nieto MA | 2008 | EMBO Rep2008，9，4： | 1 |
| 17 | Epithelial-mesenchymal transitions in development and disease显示文摘 | Thiery JP Acloque H Huang RY | | 0，，05： | 1 |
| 18 | A modelsimulating the genesis of banded vegetation patterns in Niger显示文摘 | THIERY J M DHERBES J M VLAENTIN C | 1995 | Journal of Ecology1995，83，3： | 1 |
| 19 | Epithelial-mesenchymal transitions in tumour pro- gression显示文摘 | Thiery JP | 2002 | Nat Rev Cancer2002，2，6： | 1 |
| 20 | Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum显示文摘 | Tahar R Boudin C Thiery I | 2002 | EMBO J2002，21，24： | 1 |
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