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| 1 | Combined laparoscopic and endoscopic treatment for bile duct diseases显示文摘BACKGROUND: Clinical application of laparoscopy, duo- denoscopy and choledochoscopy has been accepted as a mini-invasive surgical therapy for bile duct diseases; but ei- ther endoscopic or laparoscopic therapy alone is disadvanta- geous in its narrow indications and in failure to give full play to the individual superiority. The present study was to evaluate the procedures and therapeutic results of combined laparoscopic and endoscopic treatment for bile duct disea- ses. METHODS: Clinical data of 1990 patients with bile duct diseases treated by combination of laparoscopy, duodenos- copy and choledochoscopy in two hospitals were reviewed and analyzed. RESULTS: Patients with cholecystolithiasis and choledo- cholithiasis were treated with combined laparoscopy and duodenoscopy (n =1350) in a single operation with a cure rate of 93.6%. Those with choledocholithiasis (n =332) were treated with combined laparoscopy and choledocho- scopy with a cure rate of 100%. Combined laparoscopy, duo- denoscopy and choledochoscopy was used in 258 patients with choledocholithiasis (29 of them complicated with pan- creatitis) and 24 patients with Mirizzi’s syndrome, with a cure rate of 100%. Laparoscopic choledochoenterostomy and preoperative endoscopic nasobiliary drainage were done in 26 patients with a cure rate of 100%. There were no serious operative complications. A follow-up study of 1051 patients for 3 months to 12 years (mean 7.8 years) showed that 10 patients had recurrence of stones but no stenosis of the bile duct. CONCLUSION: Combined laparoscopic and endoscopic procedures are mini-invasive and cause less pain and mini- mal operative complications. | Ming-Fang Qin and Hong-Bing Xu Tianjin, China Department of Endoscopic Surgery, Nankai Hospital, Tianjin 300100. China and Department of Hepatobiliary Surge- ry, PLA 309 Hospital, Beijing 100091 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 18 |
| 2 | Influence of splanchnic vascular infusion on the content of endotoxins in plasma and the translocation of intestinal bacteria in rats with acute hemorrhage necrosis pancreatitis显示文摘INTRODUCTIONThe main reason for the death of the patient with acutehemorrhage necrosis pancreatitis(AHNP)is pancreaticinfection and multi-organ failure caused by endotoxemiaand intestinal bacterial translocation.However,thepathogenesis of endotoxemia and intestinal | Qin RY Zou SQ Wu ZD Qiu FZ | 2000 | World Journal of Gastroenterology2000，6，4： | 15 |
| 3 | Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages显示文摘 | Long F Wang YX Liu L Zhou J Cui RY Jiang CL | 2005 | 第二军医大学学报2005，26，10： | 14 |
| 4 | 多层CT Willis环成像:Willis环变异与颈动脉病变及脑缺血的相关性显示文摘目的评估颈动脉内膜剥脱术病人Willis环(CoW)的变异率,并探讨变异与对照组及CT诊断的脑缺血的相关性。方法本研究经机构伦理委员会批准,回顾性分析544例颈动脉内膜剥离术病人[男331例,平均年龄(69±8)岁]和196例对照组[男117例。 | A.Varga G.D.Leo P.V.Banga C.C.Novák M.Kolossváry P.M.Horvat 郑育聪(译) 陈秀玉(校) | 2019 | 国际医学放射学杂志2019，0，2： | 12 |
| 5 | Measurement of liver volume and its clinical significance in cirrhotic portal hypertensive patients显示文摘 | Zhu JY Leng XS Dong N Qi GY Du RY | 1999 | World Journal of Gastroenterology1999，5，6： | 10 |
| 6 | 石油包裹体热动力学模拟古压力改进:饱和压力预测和体积校正显示文摘除实验室测定参数(Th,oil、Th,aqu和Fv)外,石油包裹体热动力学模拟古压力精度还极大地受控于石油组分模型、饱和压力预测以及气、液相摩尔体积的预测精度.在改进α-β组分模型前提下,利用微调组分和匹配饱和压力方法改进并验证了石油流体饱和压力预测精度;在匹配饱和压力与实验实测饱和压力前提下,利用体积转换方法匹配22组油藏流体391个常组分膨胀实验相对体积数据,从而改善了利用Peng-Robison状态方程计算油包裹体气泡充填度(20℃)和等容线的能力.最终评价了真实石油流体组分甲烷摩尔含量和等效石油流体组分甲烷摩尔含量两个组分模拟约束条件下,改进的热动力学模拟方法和PIT软件及Vtflinc软件重构捕获压力的精度.结果表明,改进的热动力学模拟古压力方法较其他两种方法可以有效地提高捕获压力预测的精度.考虑到石油包裹体甲烷摩尔含量难获取问题,利用改进后的方法结合等效流体组分约束条件是重构捕获压力的理想方法组合. | 平宏伟 陈红汉 Régis Thiéry | 2013 | 地球科学(中国地质大学学报)2013，38，1： | 9 |
| 7 | Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension显示文摘INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) with | Zhu JY Leng XS Wang D Du RY | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 8 | Effect of human autologous serum and fetal bovine serum on human corneal epithelial cell viability,migration and proliferation in vitro显示文摘AIM: To analyze the concentration-dependent effects of autologous serum(AS) and fetal bovine serum(FBS) on human corneal epithelial cell(HCEC) viability, migration and proliferation.METHODS: AS was prepared from 13 patients with nonhealing epithelial defects Dulbecco's modified eagle medium/Ham's F12(DMEM/F12) with 5% FBS, 0.5% dimethyl sulphoxide(DMSO), 10 ng/m L human epidermal growth factor, 1% insulin-transferrin-selenium, then were incubated in serum media: DMEM/F12 supplemented by 5%, 10%, 15% or 30% AS or FBS. HCEC viability was analyzed using cell proliferation kit XTT, migration using a wound healing assay, proliferation by the cell proliferation enzyme-linked immunosorbent assay(ELISA) Brd U kit. Statistical analysis was performed using the generalized linear model, the values at 30% AS or 30% FBS were used as the baselines.RESULTS: HCEC viability was the highest at 30% AS or 15% FBS and the lowest at 10% AS or 30% FBS application. HCEC migration was the quickest through 30% AS or 30% FBS and the slowest through 5% AS or 5% FBS concentrations. Proliferation was the most increased through 15% AS or 5% FBS and the least increased through 30% AS or 30% FBS concentrations. HCEC viability at 10% and 15% AS was significantly worse(P=0.001, P=0.023) compared to baseline and significantly better at 15% FBS(P=0.003) concentrations. HCEC migration was significantly worse(P≤0.007) and HCEC proliferation significantly better(P<0.001) in all concentration groups compared to baseline.CONCLUSION: For the best viability of HCEC 30% AS or 15% FBS, for HCEC migration 30% AS or 30% FBS, for proliferation 15% AS or 5% FBS should be used. Therefore, we suggest the use of 30% AS in clinical practice. | Ming-Feng Wu Tanja Stachon Berthold Seitz Achim Langenbucher Nóra Szentmáry | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 7 |
| 9 | Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock"显示文摘 | Wu YH Fischer DF Kalsbcck A Garidou-Boof ML van der Vliet J van Heijningen C Liu RY Zhou JN Swaab DE | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 10 | 单个油包裹体组分预测及其在油气成藏研究中的应用显示文摘了解单个石油包裹体详细的组分信息不仅有助于微观上定量认识油气充注过程中其成熟度的演化,还对精细刻画油气成藏过程中动力演化具有重要意义.根据石油包裹体热动力学原理,利用10个成熟度依次增大的已知组分的原油在匹配其饱和压力和改进气、液相摩尔体积计算前提下,建立了捕获不同组分原油的包裹体均一温度(Thoil)与其在室温下(20℃)气泡充填度(Fv)关系的标准图版,从而通过对比实测的Thoil和其室温下Fv与标准Thoil-Fv图版,反推出油包裹体近似等效流体组分.对东营凹陷北带民丰深层油包裹体进行系统荧光分析、显微测温和包裹体体积3D重构等一系列的测定.结果表明丰8井和丰深1井各发生过两幕油气充注,其中丰8井第一幕油气充注(甲烷摩尔含量位于31%~35%之间)对其油气成藏贡献最大;而丰深1井第二幕充注的油气(甲烷摩尔含量大于60%)控制丰深1井凝析油藏成藏.从而为进一步厘定北带深层油气充注PVTxt史奠定基础. | 平宏伟 陈红汉 宋国奇 Thiéry Régis | 2012 | 地球科学(中国地质大学学报)2012，37，4： | 7 |
| 11 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 12 | 甲烷摩尔含量约束的石油包裹体捕获压力预测模型显示文摘石油包裹体显微测温和体积分析已经被广泛应用于重构石油包裹体组分和压力-温度(P-T)捕获条件,然而,其P-T捕获条件准确预测除精确的均一温度(Thoil)和气泡充填度(Fv)测试外,还依赖于石油饱和压力和体积预测能力.基于改进石油流体饱和压力和气、液相摩尔体积预测精度,建立了石油流体C7+组分摩尔含量与其Thoil和室温(20℃)下Fv之间的定量关系.尽管利用该定量关系可以极大地简化石油包裹体热动力学模拟过程,还是不能避免Fv对热动力学模拟精度的影响.因此,根据大量已知组分石油流体建立了甲烷摩尔含量约束的新的石油包裹体捕获压力预测模型.新模型中唯一变量即为石油包裹体甲烷摩尔含量,并且不再依赖于专业的热动力学模拟软件(PVTsim、VTflinc、PIT和FIT-OIL),从而极大地简化了传统石油包裹体捕获压力重构过程.最终,新模型捕获压力预测精度得到评价,石油包裹体甲烷摩尔含量对捕获压力重构具有重要控制作用,单个石油包裹体甲烷含量定量化是未来石油包裹体捕获压力重构的主要研究方向. | 平宏伟 陈红汉 Thiéry Régis | 2014 | 地球科学(中国地质大学学报)2014，39，1： | 6 |
| 13 | 原油裂解对油包裹体均一温度和捕获压力的影响及其地质意义显示文摘通过原油裂解动力学和石油包裹体热动力学模拟方法系统阐述了地质条件下原油裂解过程对油包裹体均一温度及捕获压力的影响.结果表明:初始裂解阶段(TR〈13%,T〈160℃),油包裹体均一温度随原油裂解呈增大趋势,捕获压力呈减小趋势;随着裂解程度增大(TR〈24%,T〈190℃),油包裹体均一温度随原油裂解呈减小趋势,捕获压力呈增大趋势,但此阶段油包裹体均一温度仍高于初始捕获时均一温度,捕获压力仍小于初始捕获压力;此后,随着原油裂解程度不断增大,油包裹体均一温度持续减小甚至到负值,捕获压力则持续增大甚至超过静岩压力.封闭条件下低程度的原油裂解(T〈160℃,TR〈13%)只会形成常压或者低压;而较高程度的原油裂解(TR〉40%)才会形成超压,甚至超过上覆静岩压力(TR〉70%).深部原油裂解气勘探中要特别注意地层温度位于160~190℃范围内的常压到低压油气藏,而地层温度高于190℃原油裂解气勘探应以找超压–超高压油气藏为主. | 平宏伟 陈红汉 Régis Thiéry 张晖 李培军 吴楠 | 2014 | 地球科学(中国地质大学学报)2014，39，5： | 6 |
| 14 | Effects of aging on the microstructures and mechanical properties of extruded AM50+xCa magnesium alloys显示文摘The effects of aging treatment on the microstructures and mechanical properties of extruded AM50 + xCa alloys (x = 0, 1, 2 wt.%) were studied. The results indicated the secondary phase Mg17Al12 precipitated from the saturated α-Mg solid solution while Al2Ca changed slightly when the aging time was increased. The hardness of extruded AM50 + xCa al-loys increased initially to its peak, and then dropped to reach its original hardness with the increase in aging time. With the increase in aging temperature, the hardness of the AM50 + 2Ca alloy decreased, whereas the hardness of AM50 and AM50 + 1Ca alloys decreased in the initial stages of aging treatment and increased in the later stages of aging treatment. The tensile strengths of AM50 and AM50 + 1Ca alloys increased after aging treatment for the precipitation of Mg17Al12 phase, which increases the resistance against dislocation movement at the grain boundary; with increase in aging temperature, their tensile strengths in-creased. For AM50 + 2Ca alloy, the tensile strength declined after aging at 150°C and 175°C, while it increased slightly at 200°C. The ductility of AM50 + xCa alloys (x = 0, 1, 2 wt.%) declined after aging treatment. | WANG Qudong PENG Jianguo Suéry Michel Jean-Jacques Blandin | 2006 | Rare Metals2006，25，4： | 6 |
| 15 | Intensity correction in all-sky auroral image projection transform显示文摘BY using all-sky(fish-eye)lens and highly sensitive TV camera,the effective monitoring ra-dius and time resolution of ground aurora observation have now been raised to 600 km and1/30 s(for instance,SIT-TV camera recording in NTSC format).By incorporating high-sen-sitivity imaging device(integrated from image intensifier and CCD(charge coupled device) | Yang, YG Liu, RY Sato, NS | 1997 | Chinese Science Bulletin1997，42，8： | 5 |
| 16 | Quantum chemical studies on antimalarial of artemisinin (qinghaosu) derivatives显示文摘In this paper theoretical studies were performed on artemisinin (qinghaosu) derivatives with semiempirical quantum chemical methods AMI and PM3. The antimalarial activity -logC has an obvious correlation with the net charge of C(16) and bond orders of bonds O(1)-C(10), O(2)-C(6), O(1)-O(2) and O(5)-C(16). According to the calculation results, we derived structure-activity relationship, presented the probable pharmacophore of qinghaosu derivatives and the interaction fashion between the drugs and the plasmodium receptor. | JIANG, HL CHEN, KX TANG, Y CHEN, JZ JI, RY | 1995 | Chinese Journal of Chemistry1995，13，2： | 5 |
| 17 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 18 | ALIZEXOL A.A NOVEL PROTOSTANE TYPE OF TRITERPENE FROM ALISMA ORIENTALIS(SAM).JUZEP显示文摘ALIZEXOLA.ANOVELPROTOSTANETYPEOFTRITERPENEFROMALISMAORIENTALIS(SAM).JUZEP￥LUZENG;XIANPENANDRUYIZHANG(DepartmentofPhytochemist... | Zeng, L Pen, X Zhang, RY | 1995 | Chinese Chemical Letters1995，6，8： | 4 |
| 19 | Heterogeneous populations of neural stem cells contribute to myelin repair显示文摘As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis(MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demonstrated the increasing inability of oligodendrocyte precursor cells(OPCs) to replace lost oligodendrocytes(OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair. | Rainer Akkermann Felix Beyer Patrick Küry | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 20 | Electrochemistry of samarium in lithium-beryllium fluoride salt mixture显示文摘The electrochemical behaviour of samarium was investigated in LiF-BeF2 system on an inert (Mo) electrode by cyclic voltammetry and chronopotentiometry at 804, 833, 847 and 872 K. Redox process Sm3++e-→Sm2+ was recognized and analysed. Cyclic voltammetry data suggested that at potential sweep rates lower than 0.25 V/s, the reduction was limited by the diffusion of Sm3+ ions. It was not possible to observe reduction process of Sm2++2e-→Sm0 due to insufficient electrochemical stability of LiF-BeF2. Diffusion coefficients of Sm3+ ions in LiF-BeF2 were calculated from voltammetric and chronopotentiometric data in the temperature range 804-872 K. Diffusion coefficient values obeyed Arrhenius law. Activation energy was calculated to be 102.5 kJ/mol. | Martin Straka Michal Korenko Frantisek Lisy Lórant Szatmáry | 2011 | Journal of Rare Earths2011，29，8： | 3 |
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