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| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | PAX6 gene analysis in irido-fundal coloboma显示文摘 | Kumar K Tanwar M Naithani P | | 0，，： | 1 |
| 3 | DNA integrity and semen quality in men with low seminal antioxidant levels显示文摘 | Shamsi M B Venkatesh S Tanwar M | 2009 | Mutatation Research2009，665，12： | 1 |
| 4 | Early detection and prognosis of ovarian cancer using serum YKL-40显示文摘 | Dupont J Tanwar M K Thaler H T | 2004 | JClin Oncol2004，22，16： | 1 |
| 5 | Effect of muscle energy tech- nique to improve flexibility of gastro-soleus complex in plan- tar fasciitis: a randomised clinical, prospective study design 显示文摘 | Tanwar R Moitra M Goyal M | 2014 | Indian Journal of Physiotherapy and Occupational Thera- py-An International Journal2014，8，4： | 1 |
| 6 | Innovative sampling andextraction methods for the determination of nonsteroidal anti - in-flammatory drugs in water显示文摘 | TANWAR S DI CARRO M MAGI E | 2015 | Journal of Pharmaceutical and Bi-omedical Analysis2015，106，： | 1 |
| 7 | Curcumin protects rat myocardium against isoproterenol-induced ischemic injury:attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system显示文摘 | Tanwar V Sachdeva J Golechha M | 2010 | J Cardiovasc Pharmacol2010，55，4： | 1 |
| 8 | Mutation spectrum of CYP1B1 in North Indian congenital glaucoma patients显示文摘 | Tanwar M Dada T Sihota R | 2009 | Mol Vis2009，15，： | 1 |
| 9 | Comet assay:a prognostic tool for DNA integrity assess- ment in infertile men opting for assisted reproduction显示文摘 | SHAMSI MB VENKATESH S TANWAR M | 2010 | Indian J Med Res2010，131，： | 1 |
| 10 | Cytogenetic and clinical assessment of a family with Treacher Collins Syndrome 显示文摘 | Kumar M Kumar R Tanwar M | 2011 | Case Rep Med2011，23，： | 1 |
| 11 | Anconeus pediele olecra- non flip osteotomy : an approach for the fixation of complex intra- articular distal humeral fractures 显示文摘 | Habib M Tanwar YS Jaiswal A | 2014 | Bone Joint J2014，96，9： | 1 |
| 12 | Robertsonian trans- location and their role in pathogenesis of recurrent in vitro fertilization failure 显示文摘 | Kumar R Tanwar M Ammini AC | 2008 | Med Sci Monit2008，14，12： | 1 |
| 13 | DNA integrity and se- men quality in men with low seminal antioxidant levels 显示文摘 | Shamsi MB Venkatesh S Tanwar M | 2009 | Murat Res2009，665，12： | 1 |
| 14 | Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma显示文摘 | Tanwar M K Gibert M R Holland E C | 2002 | Cancer Res2002，62，15： | 1 |
| 15 | Curcumin protects rat myocardium against isoproterenol-induced isehemic injury: attenuation of ventricular dysfunction through increased expres- sion of Hsp27 along with strengthening antioxidant defense sys- tem 显示文摘 | Tanwar V Sachdeva J Golechha M | 2010 | J Cardiovasc Pharmacol2010，55，4： | 1 |
| 16 | MYOC and FOXC1 gene analysis in primary congenital glaucoma显示文摘 | Tanwar M Kumar M Dada T | 2010 | Mol Vis2010，16，5： | 1 |
| 17 | Early detection and prognosis of ovarian cancer using serum YKL-40显示文摘 | Dupont J Tanwar M K Thaler H T | 2004 | Journal of Clinical Oncology2004，22，16： | 1 |
| 18 | Minimally inva- sive plate osteosynthesis of distal tibial fracture using a posterolateral approach:a cadaveric study and prelimina- ry report显示文摘 | Tanwar YS Habib M Jaiswal A | 2013 | Int Orthop2013，37，5： | 1 |
| 19 | Curcumin protects rat myocardium against isoproterenol-induced ischemic injury:attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system显示文摘 | Tanwar V Sachdeva J Golechha M | 2010 | J Cardiovasc Pharmacol2010，55，4： | 1 |
| 20 | Record of new parasitoids on mealybug,Phenacoccus solenopsis显示文摘 | Tanwar RK Bhamare VK Ramamurthy VV Hayat M Jeyakumar P Singh A Bambawale OM | | 0，，04： | 1 |
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