|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 2 | Triple plating of tibia in a complex bicondylar tibial plateau fracture显示文摘高精力的胫骨的高原骨折为整形外科的外科医生提出重要挑战和困难。胫骨的高原的骨折包含主要重量适用连接并且可以改变膝 kinematics。近似胫骨的关节的表面,手足轴(手足排列) 的恢复和允许早联合的运动的稳定的固定的解剖重建是处理的目标。在胫骨的高原折断的复杂 bicondylar 的情况下,孤立侧面的 plating 经常与内翻足 malalignment 被联系,更好的结果通过双切口与双边的 plating 被获得了。然而,有时,胫骨的高原折断的 bicondylar 的一种复杂类型在中间的高原在哪个让 biplaner 象 sagittal 飞机一样在以后的花冠飞机断裂被遇到。在如此的破裂,与在两架飞机支持修理中间的高原是必要的。近似胫骨的一个如此的破裂模式通过双 posteromedial 由三倍的 plating 设法,在前面偏一边的切口在这类损害,外科的途径和管理的机制上与强调在这份情况报告被讨论。 | Atin Jaiswal Naiman Deepak Kachchhap Yashwant S Tanwar Birendra Kumar Sachin K Yadav | 2014 | Chinese Journal of Traumatology2014，17，3： | 10 |
| 3 | Liver transplantation for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the commonest primary malignancy of the liver. It usually occurs in the setting of chronic liver disease and has a poor prognosis if untreated. Orthotopic liver transplantation (OLT) is a suitable therapeutic option for early,unresectable HCC particularly in the setting of chronic liver disease. Following on from disappointing initial results,the seminal study by Mazzaferro et al in 1996 established OLT as a viable treatment for HCC. In this study,the 'Milan criteria' were applied achieving a 4-year survival rate similar to OLT for benign disease. Since then various groups have attempted to expand these criteria whilst maintaining long term survival rates. The technique of living donor liver transplantation has evolved over the past decade,particularly in Asia,and published outcome data is comparable to that of OLT. This article will review the evidence,indications,and the future direction of liver transplantation for liver cancer. | Sudeep Tanwar Shahid A Khan Vijay Paul Bob Grover Catherine Gwilt Belinda Smith Ashley Brown | 2009 | World Journal of Gastroenterology2009，15，44： | 4 |
| 4 | Prevalence of excessive internet use and its correlation with associated psychopathology in 11th and 12th grade students显示文摘Background Globally, the number of internet users has crossed the three-billion mark, while in India users grew over 17% in the first 6 months of 2015 to 354 million. This study presented a background on internet use and the existence of excessive internet use. Aim To study the extent of internet use in 11th and 12th grade students and the psychopathology, if any, associated with excessive internet use. Methods 426 students who met the inclusion criteria were recruited from 11 th and 12th grade classes from Kendriya Vidyalaya, New Delhi, India, and were assessed by Young's Internet Addiction Test and the Strength and Difficulties Questionnaire. Results Among the 426 students, the mean internet addiction total score was 36.63 (20.78), which indicated mild level of internet addiction. 1.41%(six students) was diagnosed as excessive internet users, while 30.28% and 23.94% were classified as moderate and mild internet users, respectively. The prevalence of internet addiction between gender was 58.22% in males and 41.78% in females. While both positive (prosocial) and negative (hyperactivity, emotional, conduct and peer problem) impacts of internet use were reported by students, in the current study excessive use of internet had a negative impact on students' lives as compared with positive impact, which was statistically significant (p<0.0001). Conclusion Excessive internet use led to abnormal behaviours which cause negative consequences to users. Early diagnosis of risk factors related to excessive internet use, provides education about responsible use and supervision of students by family members. | Nitin Kumar Arvind Kumar Subodh Kumar Mahto Manish Kandpal Smita Neelkanth Deshpande Parul Tanwar | 2019 | General Psychiatry2019，32，2： | 3 |
| 5 | Celiac disease:Overview and considerations for development of gluten-free foods显示文摘Celiac disease is a genetically-determined chronic inflammatory intestinal disease induced by gluten in wheat,barley,rye etc.Celiac disease affects approximately one percent of people in the world and strict gluten-free diet(GFD)for a lifetime is the only available treatment.As gluten-free products available in the market are known to have low nutritional quality as well as are more expensive than gluten-containing food products,there is a strong need to develop gluten-free products that are nutritionally complete as well as economical.This review focuses on the special considerations during developing gluten-free products viz.,finding an alternate non-gluten source,ensuring nutrition and sensory quality characteristics,compliance with the regulatory guidelines,economics and product. | Prakriti Jnawali Vikas Kumar Beenu Tanwar | 2016 | Food Science and Human Wellness2016，5，4： | 2 |
| 6 | Primary tuberculosis of the thyroid gland:a case report显示文摘Tuberculosis of the thyroid gland is an uncommon disease and primary involvement of Uiyroid is even more rare.It is a rare disease even in countries in which tuberculosis is endemic.The diagnosis is often difficult as the clinical presentation has no distinct characteristics.Clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic growth pattern without specific symptomatology.Histologically presence of necrotizing epithelioid cell granulomas along with langhans type giant cells are the hallmark of thyroid tuberculosis.Demonstration of acid fast bacilli by ZN staining confirms the diagnosis,but this stain is frequently negative in tissue sections. | Sant Parkash Kataria Parul Tanwar Sneh Singh Sanjay Kumar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 2 |
| 7 | Bilateral traumatic proximal humerus fractures managed by open reduction and internal fixation with locked plates显示文摘近似肱骨的破裂在年轻病人是不平常的。尽管近似肱骨本身的双边的骨折是稀罕的,有癫痫和电刑的协会是经常的。仅仅创伤的双边的近似肱骨骨折的一个案例在文学被报导了。我们在 40 岁男性病人报导双边的创伤的代替的近似肱骨破裂的一个稀罕案例,它与近似肱骨借助于开的减小和内部固定被对待在双方上锁了头并且获得了好功能的结果。 | Atin Jaiswal Naiman Deepak Kachchhapt Rupak Chaterjee Yashwant Singh Tanwar Masood Habib Satya Prakash Singh | 2013 | Chinese Journal of Traumatology2013，16，6： | 2 |
| 8 | First rib fractures: not always a hallmark of severe trauma a report of three cases显示文摘 | Atin Jaiswal Yashwant S Tanwar Masood Habib Vijay Jain | 2013 | Chinese Journal of Traumatology2013，16，4： | 2 |
| 9 | Curcumin: an adjuvant therapeutic remedy for liver cancer显示文摘The molecular signalling pathways for hepatocellular carcinoma and hepatoblastoma have been extensively studied.The treatment of these highly vascular tumors mainly revolves around chemotherapy and surgery.Yet there is a high associated morbidity and mortality due to advanced stages,adverse effects owing to chemotherapy and recurrence.The role of Curcumin as an adjuvant remedy is explored in this article.Curcumin stimulates apoptosis of cancer cells,acts as anti-proliferative agent,has anti-angiogenic action,prevents tumor invasiveness and metastasis and prevents recurrence.It also has been proven to decrease the adverse effects of chemotherapeutic agents and has a synergistic anticancer action.It acts at the molecular level and affects the various metabolic pathways involved in tumorigenesis.It also promotes healing and has anti-inflammatory,anti-oxidant and anti-infective action.This natural phytocompounds has immense anti-cancer potential and holds future promise as an adjuvant remedy to treat liver cancer. | Shilpa Sharma Anshul Tanwar Devendra K.Gupta | 2016 | Hepatoma Research2016，2，1： | 2 |
| 10 | Intermittent cyclic process for enhanced biological nutrient removal treating combined chemical laboratory wastewater 显示文摘 | Tanwar P Nandy T Khan R | 2007 | Bioresour Techno12007，98，13： | 1 |
| 11 | PAX6 gene analysis in irido-fundal coloboma显示文摘 | Kumar K Tanwar M Naithani P | | 0，，： | 1 |
| 12 | Early detection and prognosis of ovarian cancer using serum YKL-40 显示文摘 | Dupont J Tanwar MK Thaler HT | 2004 | J Clin Oncol2004，22，16： | 1 |
| 13 | Early detection and prognosis of ovarian cancer using serum YKL-40 显示文摘 | Dupont J Tanwar MK Thaler HT | 2004 | J Clin Oncol2004，22，16： | 1 |
| 14 | The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling 显示文摘 | Tanwar PS Commandeur AE Zhang L | 2012 | Carcinogenesis2012，33，： | 1 |
| 15 | Altered LKBlIAMPKI TSC lrrSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis显示文摘 | Tanwar PS Kaneko-Tarui T Zhang L | 2012 | Hum Mol Genet2012，21，20： | 1 |
| 16 | DNA integrity and semen quality in men with low seminal antioxidant levels显示文摘 | Shamsi M B Venkatesh S Tanwar M | 2009 | Mutatation Research2009，665，12： | 1 |
| 17 | Early detection and prognosis of ovarian cancer using serum YKL-40 显示文摘 | Dupont J Tanwar MK Thaler HT | 2004 | J Clin Oncol2004，22，： | 1 |
| 18 | Early detection and prognosis of ovarian cancer using serum YKL-40显示文摘 | Dupont J Tanwar M K Thaler H T | 2004 | JClin Oncol2004，22，16： | 1 |
| 19 | Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway显示文摘 | Tanwar V Bylund JB Hu J | 2014 | Stem Cells2014，32，7： | 1 |
| 20 | Percutaneous elevation of depressed lunate fossa: A surgical technique显示文摘远侧的半径的死穿孔机破裂或装紧破裂关节的表面对对待并且努力困难完成令人满意的减小。我们在场提高沮丧的半月形的窝并且在这没有 grafting 的需要维持提高的碎片的减小的一种唯一、经皮、最低限度地侵略的技术断裂。这种技术简单,可再现并且能与简单乐器学被执行。我们认为它在远侧的半径破裂的处理值得许多含意。 | Atin Jaiswal Yashwant Singh Tanwar | 2018 | Chinese Journal of Traumatology2018，21，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员