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| 1 | 膝关节粘连:治疗和预防研究新进展显示文摘背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为防治膝关节粘连提供新的思路和方法。方法:由第一作者检索Pub Med数据库,查找2006至2016年的文献,英文检索词为'tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment',共检索到1 500余篇相关文献,59篇符合纳入标准。结果与结论:(1)近年来大量学者研究发现,创伤/手术引起膝关节出血、炎症反应,造成血管内皮细胞生长因子和白细胞介素6高表达,增加了成纤维细胞的活性,导致大量胶原蛋白沉积,发生粘连;(2)改进传统治疗方式和运用微创技术治疗膝关节粘连取得了一定的疗效,但仍存在再粘连风险;(3)关节腔内用药预防膝关节粘连在基础研究方面获得了显著成果,可成为预防膝关节粘连的一种有效方案,但临床可行性存在争议,需进一步深入研究,寻找疗效确切、不良反应小的药物。 | 吴海啸 王鹏 张超 Egiazaryan KA Ratyev AP Melnichenko SY Kuzin VV Skoroglyadov AV | 2017 | 中国组织工程研究2017，21，36： | 12 |
| 2 | Livelihood changes and evolution of upland ethnic communities driven by tourism:a case study in Guizhou Province,southwest China显示文摘As an effective livelihood approach to alleviate poverty without rural population migration, ethnic tourism has become the primary choice of economic development in ethnic areas worldwide in addition to traditional livelihood approaches. This article applies the theories of livelihood to study the community evolution driven by tourism livelihood and examine three mountainous tourism communities in different stages of tourist area life cycle. Drawing on the methods of GIS spatial analysis, semi-structured interviews and questionnaires, this article proposes a sustainable livelihood framework for ethnic tourism to explore the evolution of ethnic tourism communities by identifying changes in livelihood assets(natural, financial, social, cultural and human capitals) in the process of tourism development. The results show that the development of ethnic tourism has led to changes in the increase of building land, and the diversification of land use functions with a trend of shifting from meeting local villagers' living needs to satisfying tourists, income composition and uneven distribution of tourism income spatially. Ethnic tourism also led to the deterioration of traditional social management structure, collapse of neighboring relationship, the over- commercialization and staged authenticity of ethnic culture, as well as the gradual vanish of agricultural knowledge with a trend of increasing modern business knowledge and higher education. In addition, these changes, involving livelihood assets from natural, economic, human, social and cultural aspects are interrelated and interactive, which form new evolution characters of ethnic community. This study reveals the conflicts over livelihood approaches which have formed new vulnerabilities to impact on sustainable evolution of ethnic communities. This research provides implications for achieving the sustainable development of ethnic communities with the driving force of tourism livelihood. | LI Ya-juan VV Hu CHEN Tian HU Jing CUI Hai-yang | 2016 | Journal of Mountain Science2016，13，7： | 11 |
| 3 | Genetics of acute and chronic pancreatitis: An update显示文摘Progress made in identifying the genetic susceptibility underlying acute and chronic pancreatitis has benefitted the clinicians in understanding the pathogenesis of the disease in a better way. The identification of mutations in cationic trypsinogen gene(PRSS1 gene; functional gain mutations) and serine protease inhibitor kazal type 1(SPINK1 gene; functional loss mutations) and other potential susceptibility factors in genes that play an important role in the pancreatic secretory functions or response to inflammation during pancreatic injury has changed the current concepts and understanding of a complex multifactorial disease like pancreatitis. An indi-vidual's susceptibility to the disease is governed by ge-netic factors in combination with environmental factors. Candidate gene and genetic linkage studies have iden-tified polymorphisms in cationic trypsinogen(PRSS1), SPINK1, cystic fibrosis trans-membrane conductance regulator(CFTR), Chymotrypsinogen C(CTRC), Ca-thepsin B(CTSB) and calcium sensing receptor(CASR). Individuals with polymorphisms in the mentioned genes and other as yet identified genes are at an enhanced risk for the disease. Recently, polymorphisms in genes other than those involved in 'intra-pancreatic trypsin regulatory mechanism' namely Claudin-2(CLDN2) andCarboxypeptidase A1(CPA1) gene have also been iden-tified for their association with pancreatitis. With ever growing number of studies trying to identify the genetic susceptibility in the form of single nucleotide polymor-phisms, this review is an attempt to compile the avail-able information on the topic. | VV Ravi Kanth D Nageshwar Reddy | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 7 |
| 4 | Influence of heat treatment on the machinability and corrosion behavior of AZ91 Mg alloy显示文摘In the present study,AZ91 Mg alloy was heat treated at 410℃ for 6,12 and 24 h to investigate the influence of heat treatment on machinability and corrosion behavior.The effect of soaking time on the amount and distribution of Mg 17 Al 12(β-phase)was analyzed under the optical microscope.Microhardness measurements demonstrated the increased hardness with increased heat treatment soaking time,which can be attributed to the solid solution strengthening.The influence of super saturatedα-grains on reducing the cutting force(F z)with respect to increased cutting speed was observed as prominent.The corrosion behavior of the heat treated specimens was studied by conducting electrochemical tests.Surprisingly,corrosion rate of heat treated samples was observed as increased compared with the base material.From the results,it is evident that the machinability of AZ91 Mg alloy can be improved by producing super saturatedα-grains through heat treatment but at the cost of losing corrosion resistance. | Swetha Chowdary V Ravikumar Dumpala Anand Kumar S Kondaiah VV Ratna Sunil B | 2018 | Journal of Magnesium and Alloys2018，6，1： | 7 |
| 5 | 中等收入国家年轻人脑卒中发病率增加:基于10年人口的研究显示文摘高收入国家年轻人脑卒中的发病率正在上升。然而,低收入和中等收入国家年轻人的脑卒中发病趋势仍未知。该研究旨在分析2005—2015年在巴西Joinville的年轻人的缺血性脑卒中(isehemic stroke,IS)和脑出血的发病趋势。 | 刘莉 叶鹏 Cabral NL Freire AT Conforto AB Dos Santos N Reis FI Nagel V Guesser VV Safanelli J Longo AL | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 6 | β-TCP/α-CSH复合材料骨支架在骨缺损治疗中的应用研究进展显示文摘骨缺损的治疗是骨科面临的世界性难题之一,目前公认的治疗方法是通过骨组织工程支架进行修复填充。理想的骨组织工程支架应具备生物相容性、骨传导性、骨诱导性及降解性,同时具有合适的孔径、孔隙率和机械强度。单一材料由于其理化性质的局限性,无法满足临床需要。β-磷酸三钙(β-TCP)/α-半水硫酸钙(α-CSH)复合材料骨支架由于其在生物相容性、可吸收性及机械强度等方面的优势,在体内和体外试验中都取得了一定的效果,但β-TCP/α-CSH复合材料骨支架的机械强度会随α-CSH的完全降解而消失,因此目前其临床研究主要集中在颌面和口腔领域。β-TCP/α-CSH复合材料骨支架修复骨缺损是目前临床上较有潜力的治疗方案,其联合干细胞移植可能是未来提高临床骨缺损修复率的新方向。 | 吴海啸 张超 Goryaeva GL Kuzin VV Skoroglyadov AV | 2016 | 山东医药2016，56，32： | 3 |
| 7 | 重组腺病毒bcl-xs基因对人卵巢癌裸鼠移植瘤作用的研究显示文摘目的 观察重组腺病毒bcl xs基因 (adv bcl xs基因 ,简称bcl xs基因 )对人卵巢癌裸鼠移植瘤的生长抑制和荷瘤裸鼠生存率的影响 ,为卵巢癌的基因治疗提供实验基础。方法 采用以复制缺陷型腺病毒bcl xs基因感染的人胚肾细胞 ,使bcl xs基因在人胚肾细胞内扩增 ,扩增后的bcl xs基因感染大鼠卵巢癌细胞株NUTU 19,观察bcl xs基因对NUTU 19细胞的生长抑制作用并检测其病毒滴度后 ,将bcl xs基因导入人卵巢癌裸鼠移植瘤中 ,观察bcl xs基因对腹水的生长抑制作用 ,计算裸鼠的生存时间 ,并观察bcl xs基因对裸鼠全身和局部的毒副作用 ;电镜观察bcl xs基因的病毒颗粒 ,以免疫细胞化学染色测定bcl xs基因表达情况。结果 bcl xs基因可在人胚肾细胞内扩增 ,对NUTU 19细胞有抑制和杀伤作用 ,并在裸鼠体内呈过度表达 ,使裸鼠腹水形成的时间由 5~ 10d延长至 11~ 2 3d ,裸鼠平均生存时间由 2 4d延长至 39d。bcl xs基因对裸鼠全身和局部无明显毒副作用。结论 bcl xs基因导入人卵巢癌裸鼠移植肿瘤 ,能延缓腹水形成 ,延长裸鼠的生存时间 。 | 陈爱平 彭芝兰 王和 高国兰 刘珊玲 Baker VV | 2001 | 中华妇产科杂志2001，36，3： | 3 |
| 8 | Platelet-activating factor induces NF-kappa B activation through a G proteincoupled pathway显示文摘 | Kravchenko VV Pan Z Han J | 1995 | J Biol Chem1995，270，14： | 2 |
| 9 | EN3—32型半自动提引器显示文摘 | Grig.,VV 悠天 | 1989 | 冶金地质探矿技术1989，，1： | 2 |
| 10 | 萤石矿富选过程中矿浆流内氟含量中子活化快速检测系统的研制显示文摘研制出萤石矿富选过程中矿浆流内氟含量的中子活化快速检测系统。氟含量分析时间仅为1—4min,绝对标准偏差为(0.9—0.4)%。 | 吴国良 伊万年柯VV 库斯托夫VN 列维茨卡娅ON | 1997 | 同位素1997，10，4： | 2 |
| 11 | Dementia and white-matter demyelination in young patient with neurosyphilis 显示文摘 | Brinar VV Habek M | 2006 | Lancet2006，368，9554： | 1 |
| 12 | Prenatal detection of embryo resorption in osteopontin-deficient mice using serial noninvasive magnetic resonance microscopy显示文摘 | Weintraub AS Lin X Itskovich VV | 2004 | Pediatric Research2004，55，： | 1 |
| 13 | Attenuation of left ventricular dilation after acute myocardial infarction by early initiation of enalapril therapy 显示文摘 | Bonarjee VV Carstensen S Caidahl K | 2003 | Am J Cardiol2003，72，14： | 1 |
| 14 | Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor-positive breast cancer显示文摘 | Semiglazov VF Semiglazov VV Dashyan GA | 2007 | Cancer2007，110，2： | 1 |
| 15 | Serological evidence for the role of bacterial infections in the pathogenesis of thyroid diseases显示文摘 | Vahonen VV Ruutu P Vails K | 1986 | Acta Med Scand1986，219，1： | 1 |
| 16 | A pilot study of ICG laser therapy of acne vulgaris:photodynamic and photothermolysis treatment显示文摘 | Genina EA Bashkatov AN | 2003 | Lasers Surg Med2003，33，5： | 1 |
| 17 | Activity of vasopressin neurons in the human supraoptic nucleus:estrogen inhibitory effect显示文摘 | Dolzhikov AA Grinevich VV | 2001 | Usp Fiziol Nauk2001，32，： | 1 |
| 18 | A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-intagrin显示文摘 | Orlova VV Choi EY Xie CP | 2007 | EMBO2007，26，4： | 1 |
| 19 | Prenatal detection of embryo resorption in osteopontin - deficient mice using serial noninvasive magnetic resonance microscopy 显示文摘 | Weintraub AS Lin X hskovich VV | 2004 | Pediatr Res2004，55，： | 1 |
| 20 | MDA-MB-435 human breast carcinoma cell homo-and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-Galectin-3 interactions显示文摘 | Khaldoyanidi SK Glinsky VV Sikora L | 2003 | J Biol Chem2003，278，6： | 1 |
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