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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 3 | Repairing of goat tibial bone defects with BMP-2 gene-modified tissue-engineered bone显示文摘 | Dai KR Xu XL Tang TT Zhu ZA Yu CF Lou JR Zhang XL | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | The sphingosine kinase 1/sphingosine- 1-phosphate pathway in pulmonary arterial hypertension 显示文摘 | Chen J Tang H Sysol JR | 2014 | Am J Respir Crit Care Med2014，190，9： | 1 |
| 5 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model显示文摘 | Henderson WR Jr Tang LO Chu SJ | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 6 | A stereological method for estimating the to- tal length and size of myelin fibers in human brain white matter显示文摘 | Tang Y Nyengaard JR | 1997 | J Neurosci Methods1997，73，2： | 1 |
| 7 | Rare earth element patterns in a Chinese stalagmite controlled by sources and scavenging from karst groundwater 显示文摘 | Zhou H Y Greig A Tang Jr | 2012 | Geochimica et Cosmochimica Ac- ta2012，，： | 1 |
| 8 | Associations of extracranial carotid atheroselerosis progression with coronary status and risk factors in patients with and without coronary artery disease显示文摘 | Crouse JR Tang R Espeland MA | | 0，，16： | 1 |
| 9 | The NF-kappaB inhibitory proteins ikappaBalpha and ikappBbeta mediate disparate responses to inflammation in fetal pulmonary endothelial cells 显示文摘 | Tang JR Miehaelis KA Nozik-Grayck E | 2013 | J Immuno12013，190，6： | 1 |
| 10 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model 显示文摘 | Henderson WR Jr Tang LO Chu SJ Tsao SM Chiang GK Jones F Jonas M Pae C Wang H Chi EY | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 11 | Effective Use of Polymerase Chain Reaction for Diagnosis of Central Nervous System Infections显示文摘 | TANG YW HIBBS JR TAU KR | 1999 | Clin Infect Dis(S1058- 4838)1999，29，： | 1 |
| 12 | A stereological method for estimating the total length and size of myelin fibers in human brain white matter 显示文摘 | Tang Y Nyengaard JR | 1997 | J Neurosci Methods1997，73，2： | 1 |
| 13 | Combination of Lamivudine and adefovir therapy in HBeAg- positive chronic hepatitis B patients with poor response to adefovir monotherapy显示文摘 | Wang LC Chen EQ CaoJ Liu L Wang JR Lei BJ Tang H | 2010 | J Viral Hepatitis2010，17，3： | 1 |
| 14 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model显示文摘 | Henderson WR JR Tang LO Chu SJ | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 15 | Studies of renal injury Ⅲ : Lipid-induced nephropathy in type II diabetes 显示文摘 | Dominguez JR Tang N Xu W | 2000 | M Kidney Int2000，57，1： | 1 |
| 16 | Association of extracranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease显示文摘 | Tang R Espeland MA | 2002 | Circulation2002，106，： | 1 |
| 17 | APOE genotype and an Apo - Emimetic peptide modify the systemic and central nervous system inflammatory response 显示文摘 | Lynch JR Tang W Wang H | 2003 | The Journal of Biological Chemistry2003，278，48： | 1 |
| 18 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model显示文摘 | Henderson WR Jr Tang LO Chu SJ | 2002 | Am J Respir Crit Care Med2002，165，3： | 1 |
| 19 | A role for cysteinyl leukotrienes in airway remodeling in a mouse asth- ma model显示文摘 | Henderson W R Jr Tang L O Chu S J | 2002 | Am J Respir Crit Care Med2002，165，1： | 1 |
| 20 | Associations of extracranial carotid atherosclerosis progression with cornary status and risk factors in patients with and without coronary artery disease显示文摘 | Crouse JR 3rd Tang R Espeland MA | 2002 | Circulation2002，106，16： | 1 |
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