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| 1 | Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine显示文摘 | Wang R Yan H Tang XC | 2006 | 中国生物学文摘2006，20，10： | 70 |
| 2 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 3 | 非小细胞型胃肠道高级别神经内分泌癌作为独立亚型的病理特征显示文摘 | Shia J Tang L H Weiser M R 王文军(摘译) 张帆(审校) | 2008 | 临床与实验病理学杂志2008，24，4： | 16 |
| 4 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 5 | Distribution of Crystal Organic Fertilizer-N in Soil-plant System显示文摘The distribution of crystal organic fertilizer, urea and compound fertilizer-N in soil and plant system was researched with 15N-trace under tobacco pot experiment. The results showed that the leaf yield of tobacco used crystal organic fertilizer was 23.1% and 14.6 % higher than that of urea and compound fertilizer treatments respectively. Compound fertilizer also resulted in higher yield of 8.5% comparing with the urea treatment. Nitrogen content of the plant from the crystal organic fertilizer treatment was 138.6% and 145.7% as high as that of the compound fertilizer and urea treatments respectively. The absorbed N from the organic fertilizer was 25.1% and 27.9% more than that from the compound fertilizer and urea respectively.However, the absorbed N from the soil with the organic fertilizer was 47.4% and 58.3% more than that with compound fertilizer and urea respectively. The N use efficiency of the organic fertilizer was 9.4% and 10.1%higher than that of the compound fertilizer and urea. It indicated that the crystal organic fertilizer not only had high N use efficiency, but also stimulated tobacco taking up more N from soil. | LIU Yi-xin, HAN Yi-wang, WANG Yan-ting, HONG Li-fang XU Xi-min,TANG Shen, LIN Guan-ya and LIU Wu-ding(Department of Environmental Science , Institute of Earth and Space , University of Science and Technology of China , Hefei 230026 , P. R . China Department of Tobacco Science , University of Science and Technology of China , Hefei 230052 , P. R . China Department of Science , Technology and Education of Tobacco Monopoly Administration of China , Beijing 100052 , P. R . China Institute of Soil and Fertilizer , Yunnan Academy of Agricultural science , Kunmin 650231 , P. R . China Sanmin Tobacco Branch Company of Fujians , Sanmin 365010 , P. R . China Yongzhou Tobacco Branch Company of Hunan , Yongzhou 425000 , P. R . China Sinan Tobacco Company of Guizhou , Sinan 565100 , P. R . China Department of Resources , Environment and Agrochemistry , Huazhong Agricultural University, Wuhan 430070 , P.R.China) | 2002 | Agricultural Sciences in China2002，1，9： | 8 |
| 6 | 低分化胰腺神经内分泌癌--44例临床病理分析显示文摘胰腺低分化神经内分泌癌包括小细胞癌和大细胞癌,其比较罕见。依据WHO(2010)胃肠胰腺系统肿瘤的分级、分类标准对107例原先诊断的胰腺低分化神经内分泌癌进行重新评价,并做了神经内分泌及腺泡分化的免疫组化标记。63例被重新分类,大部分为分化良好的神经内分泌肿瘤或是腺泡细胞癌。对其余44例低分化神经内分泌癌的临床病理特征及预后进行深入探讨。结果:患者平均年龄为59岁(范围21~82岁),男/女比率为1.4。27例位于胰腺头部,3例在体部,11例在尾部。 | Basturk O Tang L Hruban R H 徐磊 | 2014 | 临床与实验病理学杂志2014，30，8： | 7 |
| 7 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 8 | 1型糖尿病循环CD4^+/CD8^+T细胞上PD-1/PD-L1表达水平在部分缓解期恢复正常显示文摘1型糖尿病(T1D)的蜜月期,又称部分缓解期(PR),主要表现为自身胰岛功能短暂恢复及外源性胰岛素需要量减少,伴随自身免疫反应下调。PR是短暂的'临床治愈阶段',诱导和延长PR是国内外学者的共同研究目标。程序性细胞死亡蛋白-1(PD-1)及其配体PD-L1是重要的免疫抑制性分子,PD-1及PD-L1的单克隆抗体在肿瘤领域应用广泛且与T1D的发病密切相关,但其在T1D患者的PR期表达变化完全未知。为了探讨T1D患者外周血T淋巴细胞PD-1、PD-L1表达水平与PR的相关性,该研究纳入湘雅二医院门诊规律复诊的T1D患者98例和健康对照49名。 | Li X Zhong T Tang R 罗说明(编译) | 2020 | 中华医学杂志2020，100，26： | 6 |
| 9 | Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma: A case report and review of the Literature显示文摘尖锐的肝失败(ALF ) 是为肝移植要求立即的评估的一种医药紧急情况。我们描述与腹水,黄疸,和脑病介绍了并且被发现由于象 T 房间白血病 / 淋巴瘤一样的生来的杀手(NK ) 有 ALF 的一个病人的一个不平常的盒子。关键免疫显型是 CD2+ , CD3+ , CD7+ , CD56+ 。这诊断,在外部血和腹水基于调查结果,与肝活体检视被证实,并且是到肝移植的禁止徵候。hematologic 恶意是暴发性的肝的失败的一个不平常的原因的文学表演的评论,和那个象 NK 一样 T 房间白血病 / 淋巴瘤是一最近相对表示特性地认出了是的实体 CD3+ 和 CD56+ 。这个盒子证明那肝活体检视在与淋巴瘤 / 白血病能引起尖锐的肝失败的象 NK 一样 T 房间诊断肝的尖锐的肝失败,和那渗入的不平常的原因是必要的。 | Evan S Dellon Shannon R Morris Wozhan Tang Cherie H Dunphy Mark W Russo | 2006 | World Journal of Gastroenterology2006，12，25： | 5 |
| 10 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 11 | Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation显示文摘Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(LT)signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils.Splenomegaly,as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues,is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice.We now present evidence that mice deficient in LTα1β2 or LTβR develop splenomegaly and increased numbers of lymphocytes in non-lymphoid tissues in a microbiota-dependent manner.Antibiotic administration to LTα1β2-or LTβR-deficient mice reduces splenomegaly.Furthermore,re-derived germ-free Ltbr−/−mice do not exhibit splenomegaly or increased inflammation in non-lymphoid tissues compared to specific pathogen-free Ltbr−/−mice.By using various LTβ-and LTβR-conditional knockout mice,we demonstrate that retinoic acid-related orphan receptorγT-positive type 3 innate lymphoid cells provide the required active LT signaling to prevent the development of splenomegaly.Thus,this study demonstrates the importance of LT-mediated immune responses for the prevention of splenomegaly and systemic inflammation induced by microbiota. | Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu | 2018 | Cellular & Molecular Immunology2018，15，7： | 3 |
| 12 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 13 | A Coupled Variable Coefficient Modified KdV Equation Arising from a Two-Layer Fluid System显示文摘A quite general coupled variable coefficient modified KdV (VCmKdV) equation in a two-layer fluid systemis derived by means of the reductive perturbation method.Making use of the CK's direct method,some similarityreductions of the coupled VCmKdV equation are obtained and their corresponding group explanations are discussed.Some exact solutions of the coupled equations are also presented. | GAO Yuan~1 and TANG Xiao-Yan~(1,2)~1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China~2 Institut Für Theoretische Physik IV,Fakultt für Physik und Astronomie,Ruhr-Universitt Bochum,D-44870 Bochum,Germany | 2007 | Communications in Theoretical Physics2007，，12： | 3 |
| 14 | 生理过度觉醒相关失眠增加高血压风险显示文摘先前的研究显示,失眠和客观睡眠时间过短与高血压风险增加相关,并推测其潜在的机制是生理过度觉醒。在该研究中,研究者通过多次睡眠潜伏期试验(multiplesleeplatencytest,MSLT)——一种睡眠/觉醒的标准测试,探讨与生理过度觉醒相关的失眠是否与高血压风险增加相关。 | Li Y Vgontzas AN Fernandez-Mendoza J Bixler EO Sun Y Zhou J Ren R Li T Tang X 戴伦 练桂丽 | 2015 | 中华高血压杂志2015，23，2： | 2 |
| 15 | Increased RhoA translocation in aorta of diabetic rats显示文摘瞄准:在糖尿病的老鼠的主动脉分析 RhoA 表示和激活。方法:男 SD 老鼠(n=70 ) 被划分成 2 个组:糖尿病的组和控制组。糖尿病被 streptozotocin (55 mg/kg ) 的静脉注射导致。老鼠 3 个星期在糖尿病的正式就职以后被学习。西方的弄污被用来测量 Rho 的表示和激活。结果:心搏率被测量 24 h/d;它在糖尿病的老鼠由 58+/-13 beats/min 减少了。当由 KCl 和血清素刺激了时,等轴的紧张证明糖尿病的主动脉的收缩显著地与控制主动脉的相比被减少。当由醋胆素刺激了时,糖尿病的主动脉的松驰被减少。在糖尿病的老鼠的大动脉的纸巾的提高的 RhoA 易位被膜界限 RhoA 的 90% 增加决定,显示 RhoA 的激活显著地在糖尿病的主动脉被增加。结论:我们的数据在调整 RhoA 上面建议那能涉及糖尿病的老鼠的脉管的机能障碍。 | Jiping TANG Ikuyo KUSAKA Amber R MASSEY Shadon ROLLINS John H ZHANG | 2006 | Acta Pharmacologica Sinica2006，27，5： | 2 |
| 16 | Bio-optical model with optimal parameter suitable for Taihu Lake in water colour remote sensing 显示文摘 | Ma R Tang J Dai J | 2006 | International Journal of Remote Sensing2006，27，19： | 1 |
| 17 | Two-echelon supply chain games in a fuzzy environment显示文摘 | Zhou C Zhao R Tang W | 2008 | Computers & Industrial Engineering2008，55，： | 1 |
| 18 | Discovery and analysis of hepatocellular carcinoma genes using cDNA microarrays显示文摘 | Li Y Li Y Tang R | 2001 | J Cancer Res Clin Oncol2001，128，7： | 1 |
| 19 | Insights into oil cracking based on laboratory experiments显示文摘 | Hill R J Tang Y C Kaplan I R | 2003 | Org Geochem2003，34，12： | 1 |
| 20 | Controllable formation and electrochemical properties of one - dimensional nanostructured spinel Li4Ti5 O12 显示文摘 | Li J R Tang Z L Zhang Z G | 2005 | Electrochemistry Communications2005，7，： | 1 |
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