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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease显示文摘 | Kato G J McGowan V Machado RF | 2006 | Blood2006，107，6： | 1 |
| 3 | Nontuberculous mycobacterial disease mortality in the United States,1999- 2010: a populatlon-baaed comparative study 显示文摘 | Mirsaeidi M Machado RF Garcia JG | 2014 | PLoS One2014，9，91： | 1 |
| 4 | Nitric oxide and pulmonary arterial pressures in pulmonary' hypertension 显示文摘 | Machado RF Londhe NMV Dweik RA el al | 2004 | Free Radic Biol Med2004，37，7： | 1 |
| 5 | Lactate dehydrogenase as a biomarker of hemolysis-associ ated nitric oxide resistance,pria- pism, legulceration,pulmonary hypertension, and death in patients with sickle cell disease 显示文摘 | Kato G J McGowan V Machado RF | 2006 | Blood2006，107，6： | 1 |
| 6 | Pulmonary hypertension:an increasingly recognized complication of hereditary hemolytic anemias and HIV infection显示文摘 | Barnett CF Hsue PY Machado RF | 2008 | JAMA2008，299，： | 1 |
| 7 | Detection of lung cancer by sensor array analyses of exhaled breath显示文摘 | Machado RF Laskowski D Deffenderfer O | 2005 | Am J Respir Crit CareMed2005，171，11： | 1 |
| 8 | Endogenous ni- tric oxide synthase inhibitors in sickle cell disease:abnormal levels and correlations with pulmonary hypertension, desatu- ration, haemolysis, organ dysfunction and death 显示文摘 | KATO GJ WANG Z MACHADO RF | 2009 | Br J Haematol2009，145，4： | 1 |
| 9 | Hospi- talization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity 显示文摘 | MACHADO RF BARST RJ YOVETICH NA | 2011 | Blood2011，118，4： | 1 |
| 10 | Nitric oxide and pulmonary arterial pressures in puhnonary hypertension显示文摘 | MACHADO RF LONDHE NERKAR M DWE|K RA | 2004 | Free Radic Biol Med2004，37，7： | 1 |
| 11 | Lactate dehydrogenase as a biomarker of haemolysis-associated nitric oxide resistance, pria- pism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease 显示文摘 | Kato GJ Mc Gowan V Machado RF | 2006 | Blood2006，107，： | 1 |
| 12 | Detection of lung cancer by sensor array analyses of exhaled breath显示文摘 | Machado RF Laskowski D Deffenderfer O | 2005 | Am J Respir Crit Care Med2005，171，11： | 1 |
| 13 | Detection of lung cancer by sensor array analyses of exhaled breath显示文摘 | Machado RF Laskowski D Deffenderfer O | 2005 | American Journal of Respiratory and Critical Care Medicine2005，171，： | 1 |
| 14 | Pulmonary hypertension: an increasingly recognized complication of hereditary hemolytic ane- mias and HIV infection显示文摘 | Barnett CF Hsue PY Machado RF | 2008 | JAMA2008，299，3： | 1 |
| 15 | Lactatedehydrogenase as a biomarker of hemolysis-associatednitric oxide resistance,priapism,leg ulceration,pulmonary hypertension,and death in patients withsickle cell disease显示文摘 | Kato GJ McGowan V Machado RF | 2006 | Blood2006，107，6： | 1 |
| 16 | Pulmonary hypertension in patients with hemoglobinopathies: could a mechanism for dysfunction provide an avenue for novel therapeutics 显示文摘 | Lin EE Gladwin MT Machado RF | 2005 | Haematologica2005，90，4： | 1 |
| 17 | Detection of lung cancer by sensor array analyses of exhaled breath 显示文摘 | Machado RF Laskowski D Deffenderfer O | 2005 | American journal of respiratory and critical care medicine2005，171，： | 1 |
| 18 | N - terminal pro - brain natriuretic peptide levels and risk of death in sickle cell disease 显示文摘 | Machado RF Anthi A Steinberg MH | 2006 | JAMA2006，296，3： | 1 |
| 19 | Atorvas tatin reduces serum cholesterol and triglycerides with limited im provement in vascular function in adults with sickle cell anemia 显示文摘 | Bereal Williams C Machado RF Mcgowan V 2nd | 2012 | Haematologica2012，97，11： | 1 |
| 20 | Nontuberculousmycobacterial disease mortality in the United States, 1999-2010:a population-based comparative study显示文摘 | Mirsaeidi M Machado RF Carcia JGN | 2014 | PLoS One2014，9，91： | 1 |
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