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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice显示文摘OBJECTIVE To investigate the neuroprotective effects of TGR5 agonist INT-777 in the Aβ_(1-42)-treated mouse model of acute neurotoxicity.METHODS Cognitive impairment was induced by single intracerebroventricular injection of aggregated Aβ_(1-42)(410 pmol per mouse;5 μL)into the mouse brain in normal ICR mice.After3 d,INT-777(0.75,1.5 or 3.0 μg per mouse) was infused into the same site.Another 3 d later,the cognition function was evaluated by Morris water maze(MWM),novel objective recognition(NOR),and Y maze tests.Furthermore,the levels of TGR5,TNF-α,IL-1β,IL-6,NF-κB p65,Iba1,caspase 3,Bcl-2,Bax,PSD95,and synaptophysin in the hippocampus and frontal cortex were detected using Western blotting.Microglia activation in the hippocampal CA1,CA3 and DG regions and frontal cortex were detected by immunohistochemistry.TUNEL staining was used to detect the apoptotic cells.The number of spines in the hippocampal CA1,CA3 and DG regions and frontal cortex was detected by GolgiCox staining.RESULTS INT-777(1.5 or 3.0 μg per mouse) significantly ameliorated memory impairment in the Aβ_(1-42)-treated mice,evidenced by increased the time spent in the target quadrant(P<0.05),and the number of target crossings(P<0.05) in the MWM test,increased the discrimination index in the NOR test(P<0.05),and increased the number of correct choices(P<0.05,P<0.01) and decreased the latency(P<0.05) to enter the shock-free compartment in the Y-maze test.Importantly,this treatment reversed Aβ_(1-42)-induced TGR5 down-regulation(P<0.05,P<0.01),suppressed the increase of nuclear NF-κB p65(P<0.05,P<0.01) and mitigated neuroinflammation,evidenced by lower proinflammatory cytokines such as TNF-α(P<0.05),IL-1β(P<0.05),IL-6(P<0.05,P<0.01),and less Iba1-positive cells in the hippocampal CA1,CA3 and DG regions and frontal cortex(P<0.05,P<0.01) as well as the protein level of Iba1.INT-777(1.5 or3.0 μg per mouse) also pronouncedly suppressed apoptosis through the reduction of TUNEL-positive cells(P<0.05,P<0.01),decreased activation of caspase 3(P<0.05),increased ratio of Bcl-2/Bax(P<0.05,P<0.01),and ameliorated synaptic dysfunction via promoting dendritic spines generation(P<0.05,P<0.01) with the upregulation of PSD95(P<0.05) and synaptophysin proteins(P<0.05).CONCLUSION INT-777 has potent neuroprotective effects against Aβ_(1-42)-induced neurotoxicity,which suggests that the activation of TGR5 could be a novel and promising strategy for the treatment of AD. | WU Xian LYU Yang-ge DU Yi-feng CHEN Fang Miranda N REED HU Mei Vishnu SUPPIRAMANIAM TANG Su-su HONG Hao | 2018 | 中国药理学与毒理学杂志2018，32，9： | 6 |
| 3 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 4 | Stretch flanging of V shaped sheet metal blanks显示文摘 | Wang N M Johnson L K Tang S C | 1983 | J Applied Metalworking1983，3，3： | 2 |
| 5 | Silicon nanowires prepared by laser ablation at high temperature显示文摘 | Zhang Y F Tang Y H Wang N | 1998 | Appl Phys Lett1998，72，15： | 2 |
| 6 | 北京50岁及以上人群接种重组带状疱疹疫苗对公共卫生的潜在影响显示文摘带状疱疹(HZ)是由潜伏的水痘-带状疱疹病毒再激活引起的一种伴有疼痛的单侧皮疹的皮肤病,其病因与年龄相关的免疫功能下降或免疫功能抑制有关。据估计,中国每年新发HZ病例可达277万例。2019年,重组带状疱疹佐剂疫苗(RZV)在中国获批用于50岁及以上成人预防HZ,成为我国首个用于预防HZ的疫苗。本研究基于北京市人口统计学和流行病学数据,使用ZONA模型并按照一生计算,50岁及以上人群接种RZV和未接种疫苗对于公共卫生的影响。 | 王富珍(编译) Lee C Jiang N Tang H | 2022 | 中华医学杂志2022，102，12： | 2 |
| 7 | Resting Energy Expenditure and Subsequent Mortality Risk in Peritoneal Dialysis Patients显示文摘 | Wang A Y Sea M M Tang N | 2004 | J Am Soe Nephrol2004，15，12： | 1 |
| 8 | A Laplacian spectral method for stereo correspondence显示文摘 | Tang J Liang D Wang N | 2007 | Pattern Recognition Letters Elsevier2007，28，12： | 1 |
| 9 | Shock-wave initiation of heterogeneous reactive solids显示文摘 | Johnson J N Tang P K Forest C A | 1985 | J Appl Phys1985，57，9： | 1 |
| 10 | In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors 显示文摘 | Tang J Akao T Nakamura N | 2007 | Drug Metab Dispos2007，35，10： | 1 |
| 11 | The use of metformin for women with PCOS undergoing IVF treatment 显示文摘 | Tang T Glanville J Orsi N | 2006 | Hum Reprod2006，21，6： | 1 |
| 12 | Thermodynamic Evaluation of the Fe-Zn System显示文摘 | Su X Tang N Y Toguri J | 2001 | J Alloys & Compounds2001，325，： | 1 |
| 13 | New core promoter element in RNA polymerase Ⅱ-dependent transcription: Sequencespecific DNA binding by transcription factor IIB显示文摘 | Lagrange T Kapanidis A N Tang H | 1998 | Genes Dev1998，12，： | 1 |
| 14 | Morphology of Si nanowires synthesized by high-temperature laser ablation 显示文摘 | TANG Y H ZHANG Y F WANG N | 1999 | J Appl Phys1999，85，11： | 1 |
| 15 | Cloning and characterization of transferrin cDNA from Coho Salmon (Oncorhynchus kisutch)显示文摘 | Lee J Y Tange N Yamashita H | 1995 | Fish Pathology1995，30，4： | 1 |
| 16 | Physicochemical properties and functionality of rice bran protein hydro- lyzate prepared from heat-stabilized defatted rice bran with the aid of enzymes显示文摘 | Tang S Hettiarachchy N S Horax R | 2003 | Journal of Food Sci2003，68，1： | 1 |
| 17 | Static and dynamic analysis of carbon nanotube-based switches显示文摘 | DEQUESNES M TANG ZH ALURU N R | 2004 | Journal of Engineering Materials and Technology2004，126，： | 1 |
| 18 | Thermodynamic evalu- ation of the Fe-Zn system显示文摘 | Su Xuping Tang N Y Toguri J M | 2001 | J Alloys Compd2001，325，12： | 1 |
| 19 | Decentralized robust control of building structures under seismic excitations显示文摘 | Ma T W Xu N S Tang Y | 2008 | Earth- quake Engng Struct Dyn2008，37，1： | 1 |
| 20 | Integrated Pest Management Models and Their Dynamical Behaviour显示文摘 | TANG S Y XIAO Y N CHEN L S | 2005 | Bull Math Biol2005，67，： | 1 |
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