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| 1 | Experimental studies of linear phased-array transmitter acoustic logging in cased wells with scaled borehole models显示文摘Laboratory cased-hole acoustic logging simulations are developed with the linear phased-array transmitter in scaled cased well models for evaluating the feasibility of extracting formation acoustic parameters through casing.The full waveforms are measured with different cement bonding models.By analyzing the measured wavetrains and the time-slowness correlation graphs,it is showed that when the generation conditions of the refracted compressional wave and the refracted shear wave are reached successively by regulating the direction of acoustic beam radiated from the linear phased-array transmitter,steered angle of the main radiation lobe with both good bonding interfaces.The refracted compressional wave and the refracted shear wave can be stimulated obviously and the casing wave can be suppressed effectively,even when the casing and cement(or the cement and formation) is not bonded.Based on these observations, it is worthwhile to apply the linear phased-array transmitter to determine formation velocities,particularly in poorly bonded cased well.The works establish the experimental and theoretical foundation for new generation cased-hole acoustic logging tool development. | CHEN Xuelian DONG Xingmeng TAN Baohai LI Gang | 2013 | Chinese Journal of Acoustics2013，32，3： | 5 |
| 2 | Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model显示文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell. | HANYU WANG YUANHAO YANG XIAO ZHANG YAN WANG HUI FAN JINFENG SHI XUELIAN TAN BAOSHI XU JINGCHAO QIANG ENZHUANG PAN MINGYI CHU ZIBO DONG JINGQUAN DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 4 |
| 3 | Microcalorimetric study of the effect of artesunate on the growth metabolism of mitochondria isolated from rat liver显示文摘 | Xuesong Shen Meihua Jin Chunxia Zhao Xinqiang Tan Hanfu Liu Xuelian Qin Zhuangpingi Qiu Yi Liu | 2013 | Journal of Thermal Analysis and Calorimetry2013，，3： | 1 |
| 4 | An Ethical Study of Cross-Cultural Transmission显示文摘Cross-culural transmission is a complex social practice with distinct ethical attributes.Chinese and Western ethics have different connotations which always result in cultural conflicts in the cross-cultural transmission.Therefore,people should follow the thical stratcgies of abandoning ethnocentrism,advocating culural diversity and taking respect as the bottom-line ethics.Ethical turn is inevitable in the study of cros-cultural transmission. | Luo Xianfeng Tan Xuelian | 2020 | 学术界2020，，10： | 0 |
| 5 | Clinical outcomes of asymptomatic low-grade esophagitis:results from a multicenter Chinese cohort显示文摘Background:Asymptomatic low-grade(Los Angeles Classification Grades A and B)esophagitis is common in clinical practice with unclear clinical outcomes.This study aimed to explore the clinical outcomes of asymptomatic low-grade esophagitis.Methods:This was a multicenter cohort study conducted by three academic hospitals in China.Asymptomatic low-grade esophagitis patients between January 2015 and December 2019 were included.Mucosal healing condition 1year after initial diagnosis,symptomoutcomes,and proton-pump inhibitor(PPI)use within 1year after initial diagnosis were studied and compared.Results:A total of 248 asymptomatic low-grade esophagitis patients were included.Esophagitis disappeared in 76.2%of patients 1 year after initial diagnosis.In terms of symptom outcomes,89.9%of patients did not present gastroesophageal reflux disease(GERD)symptoms within 1 year after initial diagnosis.No significant difference was found in the proportion of patients who presented GERD symptoms and in the proportion of patients with persistent esophagitis between the PPI group and the non-PPI group(all P>0.05).Patients with initial Grade B esophagitis were more likely to present follow-up GERD symptoms(16.0%vs 7.5%,P=0.041)and had more severe follow-up esophagitis than those with Grade A(P<0.001).Patients with follow-up GERD symptoms were more likely to have persistent esophagitis than those without.Conclusions:This study demonstrated that asymptomatic low-grade esophagitis had relatively benign clinical outcomes.Patients with initial Grade B esophagitis and patients with follow-up GERD symptoms were more likely to be those who are in genuine need of further follow-up and treatments. | Songfeng Chen Xuelian Xiang Xiaohao Zhang Qianjun Zhuang Niandi Tan Xun Hou Mengyu Zhang Junnan Hu Chaofan Duan Yi Cui Jinhui Wang Xiangbin Xing Nina Zhang Yinglian Xiao | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 6 | Study on the Forming Process of Yi Medicine Tongfeng Granules显示文摘[Objectives]To optimize the forming process of Yi medicine Tongfeng Granules.[Methods]The forming process of Yi medicine Tongfeng Granules was optimized,with paste density,ethanol volume fraction,and type and proportion of excipient as influencing factors,and granule formability,solubility,moisture absorption,and angle of repose as evaluation indicators.Critical relative humidity(CRH)was investigated to select optimal storage conditions.[Results]Maltodextrin was selected as the excipient,and the best process parameters was the ratio of drug to excipient at 1∶2(g/g),under which the forming rate,solubility,moisture absorption rate,and angle of repose were 81.38%,98.90%,8.81%,and 27.5°,respectively.The critical relative humidity was 72%.[Conclusions]The forming process adopted is reasonable and feasible,and can provide a reference for large-scale production of Yi medicine Tongfeng Granules. | Xuelian ZHAO Yisong LI Ling TAN Hongna SU Junzhang QUBIE Wenbing LI Yuan LIU | 2021 | Medicinal Plant2021，12，6： | 0 |
| 7 | Comprehensive profiling of lysine acetylome in Staphylococcus aureus显示文摘The Gram-positive bacterium Staphylococcus aureus(S.aureus)is a wide spread common opportunistic pathogen that causes a wide variety of infectious diseases,from benign skin infections to life-threatening diseases such as the methicillin-resistant Staphylococcus aureus(MRSA)infection.Although emerging evidence suggests that lysine acetylation may play critical roles in bacterial physiology,the atlas of acetylome in S.aureus has not been studied.To comprehensively profile protein lysine acetylation in S.aureus,we used an integrated approach that combined immune affinity peptide enrichment using anti-lysine acetylation antibody,high-pH HPLC fractionation,and HPLC/mass spectrometry analysis.This study led to the identification of 1361 non-redundant acetylation sites on 412 proteins found in a search of S.aureus protein database extracted from the Swiss-Prot database.We further performed bioinformatic analysis to characterize this modification,including gene ontology annotation,protein-protein interaction,and domain analysis of the acetylation sites.We found that the acetylated proteins were enriched in multiple biological pathways,such as ribosomal function and energy metabolism.Our data provides a rich source for functional studies of lysine acetylation in S.aureus. | ZHANG Yi WU ZhiXiang WAN XueLian LIU Ping ZHANG JiBao YE Yang ZHAO YingMing TAN MinJia | 2014 | Science China Chemistry2014，57，5： | 0 |
| 8 | Study on an electrochemical biosensor for thrombin recognition based on aptamers and nano particles显示文摘This paper presents a high specific, sensitive electrochemical biosensor for recognition of protein such as thrombin based on aptamers and nano particles. Two different aptamers were chosen to construct a sandwich manner for detecting thrombin. Aptamer I was immobilized on nano magnetic particle for capturing thrombin, and aptamer II labled with nano gold was used for detection. The electrical current generated from gold after the formation of the complex of magnetic particle, thrombin and nano gold, and then an electrochemical cell designed by ourselves was used for separating, gathering, and electrochemical detecting. Through magnetic separation, high specific and sensitive detection of the target protein, thrombin, was achieved. Linear response was observed over the range 5.6×10-12―1.12×10-9 mol/L, with a detection limit of 1.42×10-12 mol/L. The presence of other protein as BSA did not affect the detection, which indicates that high selective recognition of thrombin can be achieved in complex biological samples such as human plasma. | ZHENG Jing LIN Li CHENG GuiFang WANG AnBao TAN XueLian HE PinGang FANG YuZhi | 2007 | Science China Chemistry2007，50，3： | 0 |
| 9 | Identification of Tibetan Medical Material Dracocephalum tanguticum Maxim.显示文摘[Objectives]To explore morphological identification,macroscopical identification,microscopic identification,thin layer chromatography(TLC)identification of Tibetan medical material Dracocephalum tanguticum Maxim.,and provide experimental data for its identification and application.[Methods]The Tibetan medical material was identified by means of original plant,characters,powder,paraffin section and thin layer chromatography(TLC).[Results]Tibetan medical material D.tanguticum Maxim.was obviously distinguished in character identification and microscopic identification,and the TLC method was simple and feasible.[Conclusions]The results will provide the source work foundation for the formulation of the quality standard of Sichuan Province(draft)for Tibetan medicinal material'D.tanguticum Maxim.'and the development of pharmaceutical preparations for medical institutions. | Ling TAN Pei QUN Hongna SU Xuelian ZHAO Yisong LI Yanfei HUANG Yuan LIU | 2021 | Medicinal Plant2021，12，5： | 0 |
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