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| 1 | Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model显示文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell. | HANYU WANG YUANHAO YANG XIAO ZHANG YAN WANG HUI FAN JINFENG SHI XUELIAN TAN BAOSHI XU JINGCHAO QIANG ENZHUANG PAN MINGYI CHU ZIBO DONG JINGQUAN DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 4 |
| 2 | The role of hydrated anions in hydration lubrication显示文摘Hydration lubrication has long been invoked to account for the ultralow sliding friction between charged surfaces in aqueous environments,but still not well understood at molecular-level.Herein,we explored the lubrication effect of hydrated halogen anions on positively charged surface at the atomic scale by using three-dimensional atomic force microscopy and friction force microscopy.Atomically resolved three-dimensional imaging revealed that the anion layer was topped by a few hydration layers.The mechanical properties of the hydration layers were found mainly dependent on the concentration of electrolyte solutions and independent of the species of hydrated anions.Atomic-scale friction experiments showed that the hydration friction coefficient and friction dissipation at low concentrations were orders of magnitude lower than that at high concentrations and in pure water.Superlubricity can be achieved in low concentration electrolyte solution.These results indicated that the changes of electrolyte solution concentrations led to different adsorption state of anions on the positively charged surface which gave rise to the difference of the friction behaviors.The findings in this study reveal the role of hydrated anions in hydration lubrication and provide deep insights into the origins of hydration lubrication. | Zibo Li Qian Liu Qiang Li Mingdong Dong | 2023 | Nano Research2023，16，1： | 0 |
| 3 | Characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Silurian Longmaxi Formation in the Changning area,South Sichuan Basin,southwest China显示文摘The Lower Member of the Longrnaxi Forma-tion is generally dominated by siliceous shale,but recently we found some siltstone-mudstone rhythm sections developed in the Lower Member of the Longmaxi Formation.The study of formation mechanism of siltstone-mudstone rhythmic sedimentary sections may provide new insights into the shale sedimentary environ-ment.Therefore,we studied the characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Member of the Long-maxi Formation in the Changning area based on core observation,thin section identification,major elements and trace elements analysis.The results show the following:1)Two siltstone-mudstone rhythmic sedimentary sections are characterized by frequent interbed between black or gray-black shale and light gray siltstone,abundant argillaceous laminas and silty laminas,with obvious lithological boundaries having developed.Horizontal laminas and rhythmic laminas are well-developed in the shale layer,while the wavy laminas are well-developed in the siltstone layer.2)The major compositional elements are SiO2,Al2O3 and CaO,followed by Fe_(2)O_(3),MgO,K_(2)O and Na_(2)O.3)Compared with the world average shale,these siltstone-mudstone rhythmic sedimentary sections are rich in Mo,U and Ba,but less in V,Co,Ni,Cu.Compared with the shale layer,the siltstone layer has lower contents of V,Co and Ni.4).The geochemical redox indices,Mo-U and CIA values suggest the formation of the siltstone-mudstone rhythmic sedimentary sections are related to influences from bottom currents in an oxic condition with a warm and humid paleoclimate. | Gaoxiang WANG Lei CHEN Yang YANG Cui JING Man CHEN Xiucheng TAN Xin CHEN Di CAO Zibo WEI Minglong LI Dong HUANG | 2021 | Frontiers of Earth Science2021，15，4： | 0 |
| 4 | Liensinine alleviates septic heart injury by targeting inflammation,oxidative stress,apoptosis,and autophagy显示文摘Sepsis is one of the most commonly discussed worldwide health issues,with high rates of morbidity and mortality[1].Severe sepsis can trigger a systemic inflammatory response,which can result in organ failure and death in a short time.Of all organs,the heart is one of the most vulnerable target organs during sepsis[2].Previous research has revealed that sepsis-induced heart damage is often accompanied by uncontrolled inflammation,oxidant/antioxidant imbalance,excessive apoptosis,and autophagy. | Wei Zhang Tianling Wang Huizhen Chen Hui Fan Feixue Liu Xiao Zhang Haitao Yang Xueqing Li Zibo Dong Jingquan Dong | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 5 | Pd nanocluster-decorated CoFe composite supported on nitrogen carbon nanotubes as a high-performance trifunctional electrocatalyst显示文摘Rational design and synthesis of low-cost trifunctional electrocatalysts with improved stability and superior electrocatalytic activity for oxygen reduction reaction(ORR),oxygen evolution reaction(OER),and hydrogen evolution reaction(HER) are highly desirable but remain as the bottlenecks at the current state of technology.In this paper,the cobalt-iron(Co-Fe) composite supported on nitrogen-doped carbon nanotubes(CoFe composite/NCNTs) is synthesized.The intrinsic OER and HER catalytic activities of this CoFe composite/NCNTs composite are significantly improved with palladium(Pd) nanocluster decoration [Pd-coated(CoFe composite/NCNTs)].The as-prepared Pd-coated(CoFe composite/NCNTs) catalyst exhibits excellent trifunctional electrocatalytic activity and stability due to the interfacial coupling between Pd and(CoFe composite/NCNTs).This catalyst is successfully employed in the water electrolysis cell as both OER and HER electrode catalysts,flexible rechargeable Zn-air battery as the bifunctional ORR and OER electrode catalyst.The cell voltage of this catalyst-coated electrodes requires only 1.60 V to achieve 10 mA cm^(-2) current density for water electrolysis cell,which is comparable to and even better than that of Pt/C and Ir/C based cell.The primary Zn-air battery using this catalyst shows a constant high open-circuit voltage(OCV) of 1.47 V and a maximum power density of 261 mW cm^(-2) in the flooded mode configuration.Most importantly,a flexible Zn-air battery with this catalyst runs very smoothly without a change in voltage gap during flat,bending,and twisting positions. | Revanasiddappa Manjunatha Li Dong Zibo Zhai Jianyi Wang Qianru Fu Wei Yan Jiujun Zhang | 2022 | Green Energy & Environment2022，7，5： | 0 |
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