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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | The results of frozen section,touch preparation,and cytological smear are comparable for intraoperative examination of sentinel lymph nodes: a study in 133 breast cancer patients 显示文摘 | Brogi E Torres ME Tan LL | 2005 | Ann Surg Oncol2005，12，2： | 1 |
| 3 | Monophasic, solitary tumoefactive demylinating lesion: neuroimaing features and neuropathologiealdiangnosis显示文摘 | Tan HM Chan LL Chuah KI | 2004 | BrJradiol2004，7，： | 1 |
| 4 | A comparison of two surgical strategies for the emergency treatment of gallstone ileus显示文摘 | Tan YM Wong WK Ooi LL | 2004 | Singapore Med J2004，45，2： | 1 |
| 5 | Prevalence and determinants of diabetes and impaired fasting glucose among urban community-living adults in Gnangzhou, China 显示文摘 | H Wang Q Qiu LL Tan | 2009 | Diabetes and Metabolism2009，35，5： | 1 |
| 6 | Effective mobili- zation of hematopoietic progenitor cells in G-CSF mobilization defective CD26-/-mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis 显示文摘 | Paganessi LA Walker AL Tan LL | 2011 | Exp Hematol2011，39，3： | 1 |
| 7 | Transient paroxysmal dyskinesia as sociated with focal basal ganglia lesions显示文摘 | See SJ Chan LL Tan EK | 2003 | Eur Neurol2003，50，11： | 1 |
| 8 | MiR-210 mediates vagus nerve stimulation- induced antioxidant stress and anti-apoptosis reaction following cere- bral ischemia/reperfusion injury in rats 显示文摘 | Jiang Y Li LL Tan XD | 2015 | J Neurochem2015，134，1： | 1 |
| 9 | Monophasic, solitary tumefactive demyeIinating lesion: neuroimaging features and neuropathological diagnosis 显示文摘 | Chan LL Chuah KL | 2004 | Br J Radiol2004，77，914： | 1 |
| 10 | Clinico- radiologic correlation in unilateral and bilateral hemifacial spasm Jourmal of Neurological 显示文摘 | Tan EK Chan LL | 2004 | Sciences2004，222，： | 1 |
| 11 | Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon 显示文摘 | Tan LL Bornstein JC Anderson CR | 2008 | Neuroscience2008，156，2： | 1 |
| 12 | Comprehensive scaning of somatic mitochondrial DNA mutations in breast cancer显示文摘 | Tan DJ Bai RK Wong Ll | 2002 | Cancer Res2002，62，： | 1 |
| 13 | Prevalence and determinants of diabetes and impaired fasting glucose among urban community-dwelling adults in Guangzhou, China显示文摘 | Wang H Qiu Q Tan LL | 2009 | Diabetes Metab2009，35，5： | 1 |
| 14 | Silencing of N-Ras gene expression using shRNA decreases transformation efficiency and tumor growth in trans- formed cells induced by anti-BPDE显示文摘 | Zhou LL Jiang Y Tan A | 2008 | Toxicol Sci2008，105，2： | 1 |
| 15 | Colorectal cancer liver metastases- understanding the differences in the management of synchronous and metachronous disease 显示文摘 | Tan EK Ooi LL | 2010 | Ann Acad Med Singapore2010，39，： | 1 |
| 16 | Lymphovascular invasion enhances the prediction of non-sentinel node metastases in breast cancer patients with positive sentinel nodes显示文摘 | Weiser MR Montgomery LL Tan LK | | 0，，02： | 1 |
| 17 | Fluoride treatment and in vitro corrosion behavior of an AZSIB magnesium alloy 显示文摘 | Yan TT Tan LL Xiong DS | 2010 | Mater Sci Engineer C2010，30，5： | 1 |
| 18 | Graves' ophthalmopathy: the bony orbit in optic neuropath)5 its apical angular capacity, and impact on prediction of risk显示文摘 | Chan LL Tan HE Fook-Chong S | 2009 | AJNR Am J Neuroradiol2009，30，3： | 1 |
| 19 | PI3K/AKT pathway involvement in the osteogenic effects of osteoclast culture supernatants on preosteoblast cells显示文摘 | Chen LL Huang M Tan JY | 2013 | Tissue Eng Part A2013，19，： | 1 |
| 20 | The preparation,cytocompatibility,and in vitro biodegradation study of pure b-TCP on magnesium显示文摘 | Geng F Tan LL Jin XX | | 0，，： | 1 |
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