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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | Voxel-based detection of white matter abnormalities in mild Alzheimer disease显示文摘 | Xie S Xiao JX Gong GL Zang YF Wang YH Wu HK Jiang XX | 2006 | 中国生物学文摘2006，20，10： | 20 |
| 3 | Age of the Shahewan rapakivi granite in the Qinling Orogen, China, and its constraints on the end time of the main erogenic stage of this orogen显示文摘the Qinling Mountains in central China are a joint orogenic zone between the Sino-Korean (or North China) and the Yangtze (or South China) craton blocks, the two major tectonic units of eastern Asia. On the end time of the main orogenic stage in this orogenic | Zhang, ZQ Zhang, GW Tang, SH Lu, XX | 1999 | Chinese Science Bulletin1999，44，21： | 15 |
| 4 | Necessity and indications of invasive treatment for Budd-Chiari syndrome显示文摘BACKGROUND:The development of collaterals in Budd-Chiari syndrome has been described and these collaterals play an important role in the presentation of this disease.These collaterals are diagnostic and their use in management strategy has never been evaluated.This study aimed to investigate the indications,feasibility and necessity of invasive treatment for patients with Budd-Chiari syndrome and to determine whether such a strategy is necessary for optimal management.METHODS:Twenty-nine patients who had been treated at our unit were enrolled in this study.Based on physical and biochemical examination,and hemodynamic compensation by collaterals,18 patients underwent radiological intervention (group A),while the other 11 had no invasive treatment (group B).The related hemodynamic parameters were acquired when percutaneous angiography was performed.RESULTS:In group A,all patients underwent successfully inferior vena cava (IVC) balloon angioplasty with or without stenting.Four patients also underwent hepatic vein angioplasty.In these patients,the mean IVC pressure before and after treatment was statistically different (29.3±9.2 vs 15.1±4.6 mmHg,P<0.01).The mean IVC pressure was much lower in group B than in group A (12.9±2.4 vs 29.3±9.2 mmHg,P<0.01),but there was no difference from that of the patients after radiological treatment (12.9±2.4 vs 15.1±4.6 mmHg,P>0.05).Median follow-up was 32.3 months (mean 21.3 months;range 3-61 months).In the course of follow-up,the patients in group A survived with good systemic status except for re-stenosis in one patient who underwent re-canalization of the IVC.In group B,10 patients had good systemic status except one patient who had a meso-caval shunt because of deterioration.CONCLUSIONS:The rationale of 'early diagnosis and early treatment' is not suitable for all patients with Budd-Chiari syndrome.Satisfactory survival can be achieved in some patients without invasive treatment,who are completely compensated by rich collaterals.Nonetheless,a positive treatment procedure should be performed if the patient's situation worsens in the course of regular follow-up. | Department of General Surgery (Fu Y,Sun YL,Ma XX,Xu PQ,Feng LS,Tang Z and Luo CH),Institute of Hepatic Vascular Disease (Sun YL),Department of Radiological Intervention (Guan S and Wang ZW),First Affiliated Hospital,Zhengzhou University School of Medicine,Zhengzhou 450052,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 10 |
| 5 | Study of T-lymphocyte subsets,nitric oxide,hexosamine and Helicobacter pylori infection in patients with chronic gastric diseases显示文摘INTRODUCTIONChronic gastritis(CG)and peptic ulcer(PU)arefrequently-occurring diseases.It is now well recognizedthat Helicobacter pylori(Hp)is a major factor that leadsto CG and PU.In order to study the relationshipamong T lymphocyte subsets,NO,Hexosamine and | Zhang H Jiang SL Yao XX | 2000 | World Journal of Gastroenterology2000，6，4： | 10 |
| 6 | Voxel-based detection of white matter abnormalities in mild Alzheimer disease显示文摘 | Xie S Xiao JX Gong GL Zang YF Wang YH Wu HK Jiang XX | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 7 | Relation of ice conditions to climate change in the Bohai Sea of China显示文摘The ice conditions in the Bohai Sea and the northern Huanghai Sea greatly change from year to year with winter climate. Ice only covers below 15% of the the waters during the wannest win-ter, while it covers more than 80% during the coldest winter. Ice observation and data acquisition are outlined in the paper. The ice-covered area, the position of ice edge and the ice grades give indication of the ice conditions. The local climate of the waters can be expressed by using the air temperature of the stations of Dalian and Yingkou. The variation of the ice condition indexes with the monthly mean air temperature at Dalian from 1952 to 2000 is shown, as well. The local climate and ice conditions in the waters are affected by many factors,such as, evolution of the general atmospheric circulation and the solar activity. The delayed correlation between the ice conditions and lots of the affecting factors is analysed in the paper. The ice conditions are continuously mild since the 1990s, that is relative to the tendency of the global warming. The ice condition variation of the Bohai Sea is related to the El Nino event and the sunspot period. The seasonal evolution of the ice conditions is also described in the paper. | Bai Shan, Liu Qinzheng, Wu Huiding I. National Center fOr Marine Environmnt FOrecats, ffeijing l(XX)8I. China. | 2001 | Acta Oceanologica Sinica2001，20，3： | 7 |
| 8 | Reservoir formation cycle of Tarim Basin, NW China显示文摘CYCLICITY of basin development and evolution gives rise to several sets of source beds in Tarim Basin. Many times of generation and expulsion of hydrocarbon caused many times of petroleum accumulation and reservoir formation, and many times of tectonic activity probably resulted in the re-distribution and complete destruction of formed reservoirs. It will help us to recognize the patterns of petroleum accumulation in Tarim Basin and direct the | Lu, XX Zhang, YW Jin, ZJ | 1997 | Chinese Science Bulletin1997，42，3： | 4 |
| 9 | Cloning of environmental genomic fragments as physical markers for monitoring microbial populations in coking wastewater treatment system显示文摘 | Yan X Xu ZM Feng XX Liu YD Liu BB Zhang X J Zhu CG Zhao LP | 2007 | 中国生物学文摘2007，21，8： | 4 |
| 10 | Microbial communities in the larval midgut of laboratory and field populations of cotton bollworm (Helicoverpa armigera)显示文摘 | Hui XA Wei GF Jia SH Huang JH Miao XX Zhou Z Zhao LP Huang YP | 2007 | 中国生物学文摘2007，21，6： | 2 |
| 11 | Emission spectra produced by pulsed laser ablation of metal Al at different ambient pressures显示文摘INTERACTION between laser and material is closely related to background besides properties oflaser and material. The interaction process can be influenced to a great extent by ambient at-mosphere and pressures. In the present work, a time and space resolved diagnostic tech-nique was used to study the emission spectrum from the plume produced by a pulsed laser on | Man, BY Miao, Y Guo, XX Wang, GT Hu, XR Wang, XT | 1997 | Chinese Science Bulletin1997，42，13： | 2 |
| 12 | Step Sintering of Microwave Heating and MicrowavePlasma Heating for Alumina Ceramics显示文摘The invention of microwave induced plasma during microwave heating makes it possible to confine plasma inside a crucible, in the pressure range of 1.33 Pa to 0.5 MPa, and above 900℃.In this study, the step sintering of microwave heating and microwave plasma heating (SSMP)was proposed. In this process, microwave heating and plasma heating was ingeniously combined in one chamber, and vacuum was unnecessary for microwave induced plasma. In the first step, the microwave energy directly heated alumina ceramics to a given temperature. above which microwave will mainly ionize the gas and sustain a plasma. Then the plasma further heated alumina ceramics to the final temperature to finish sintering. Maintaining the advantages of microwave heating and plasma heating, this step sintering approach will overcome the limitation of both processes for processing ceramics. and it will be suitable for sintering all kinds of ceramics in | Zhang, JS Cao, L Yang, YJ Diao, YX Shen, XX | 1999 | Journal of Materials Science & Technology1999，15，5： | 2 |
| 13 | Relationship between state transition and photoinhibition of photosynthesis in wheat leaves显示文摘IT is well known that state transitions can keep even distribution of excitation energy betweenthe two photosystems (PS Ⅱ and PS Ⅰ), favoring efficient operation of the photosyntheticapparatus. However, state transitions are usually thought to be associated with low light con-ditions. Its physiological significance under high light conditions is still a controversial is-suc. Many people think that state transitions occur and take significant effect only under | Tan, XX Xu, DQ Shen, YG | 1997 | Chinese Science Bulletin1997，42，21： | 2 |
| 14 | Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China显示文摘 | Wei ZQ Du XX Yu YS | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 15 | Frequent loss of membranous E - cadherin in gastric cancers: A cross - talk with Wnt in determining the fate of beta -catenin显示文摘 | Cheng XX Wang ZC Chen XY | 2005 | Clin Exp Metastasis2005，22，1： | 1 |
| 16 | Effects and mechanisms of PPARalpha activator fendlbrate on myocerdial remodeling in hypertension Cell显示文摘 | Li XX Chen YG | 2008 | Mol Med2008，5，6： | 1 |
| 17 | Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 asian countries:a proposal for a new nomenclature for SCCmec Elements显示文摘 | Chongtrakool P Ito T Ma XX | 2006 | Antimicrob Agents Chemother2006，50，3： | 1 |
| 18 | Plasmid mediated KPC 2 in a Klebsiella pneumoniae isolate from China显示文摘 | Wei ZQ Du XX Yu YS | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 19 | Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mito-chondria that remain coupled despite increased uncoupling protein 3显示文摘 | Bugger H Boudina S Hu XX | 2008 | Diabetes2008，57，11： | 1 |
| 20 | Isolated left ventricular noncompaction diagnosed by transthoracic threedimensional echocardiography显示文摘 | Wang XX Song XX | 2009 | Neth Heart J2009，17，5： | 1 |
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