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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Monophasic, solitary tumoefactive demylinating lesion: neuroimaing features and neuropathologiealdiangnosis显示文摘 | Tan HM Chan LL Chuah KI | 2004 | BrJradiol2004，7，： | 1 |
| 3 | New theropies for erectile dysfunction显示文摘 | | 2002 | Int J Androl2002，23，2： | 1 |
| 4 | Men's health:sexual dysfunction,physical,and psychological health--is there a link显示文摘 | Tan HM Tong SF Ho CC | | 0，，03： | 1 |
| 5 | Hyperhomocysteinemia and atherosclerosis显示文摘 | Yang F Tan HM Wang H | 2005 | Sheng Li Xue Bao2005，57，2： | 1 |
| 6 | Bail-out stenting of the unprotected left main stem显示文摘 | Chia HM Tan KH Jackson GP | 1998 | Int J Cardiol1998，64，2： | 1 |
| 7 | Epidemiology and clinical outoome ofenterococcal bacteraemia in all acute care hospital显示文摘 | Poh CH Oh HM Tan AL | 2006 | J hdect2006，52，5： | 1 |
| 8 | Monophasic, solitary tumefactive demyeIinating lesion: neuroimaging features and neuropathological diagnosis 显示文摘 | Chan LL Chuah KL | 2004 | Br J Radiol2004，77，914： | 1 |
| 9 | Pancreatitis leading to retroperitoneal fibrosis and ureteric obstruction显示文摘 | Tan HM Khoo J Pang KP | 2003 | Med J Malaysia2003，58，2： | 1 |
| 10 | Early Vitrectomy for vitreous hemorrhage associated with retinal tear显示文摘 | Tan HS Mura M Bijl HM | | 0，，： | 1 |
| 11 | Determinants of mortality among older adults with pressure ulcers 显示文摘 | Khor HM Tan J Saedon NI | 2014 | Arch Gerentol Geriatr2014，59，3： | 1 |
| 12 | Hyperhomocysteinemia and athero- sclerosis显示文摘 | Yang F Tan HM Wang H | 2005 | Sheng Li Xue Bao2005，57，2： | 1 |
| 13 | Prophylactic Lamivudine to Improve the Outcome of Breast Cancer Patients With HBsAg Positive During Chemotherapy: A Meta-Analysis显示文摘 | Zheng Y Zhang S Tan Grahn HM | 2013 | Hepat Mort2013，13，4： | 1 |
| 14 | Early isolated triangular fibrocartilage complex tears:management by arthroscopic repair显示文摘 | Shih JT Lee HM Tan CM | 2002 | J Trauma2002，53，5： | 1 |
| 15 | Ribosomal-sequence-directed selection for endophytic streptomyces strains antagonistic to Ralstonia solanacearum to control tomato bacterial wilt显示文摘 | TAN HM ZHOU SN DENG ZJ | 2011 | Biological Control2011，59，2： | 1 |
| 16 | Hyperhomocysteinemia and atherosclerosis显示文摘 | Yang F Tan HM Wang H | 2005 | Acta Physiol Sin2005，57，： | 1 |
| 17 | Hyperhomocysteinemia anti atherosclerosis 显示文摘 | Yang F Tan HM Wang H | 2005 | Sheng Li Xue Bao2005，57，2： | 1 |
| 18 | Early vitrectomy for vitreous hemorrhage associated with retinal tears显示文摘 | Tan HS Mura M Bijl HM | | 0，，04： | 1 |
| 19 | Cadmium level in seminal ptasma may affect the pregnancy rate for patients undergoing infertility evaluation and treatment显示文摘 | Wu HM Lin -Tan DT Wang ML | 2008 | Reprod Toxicol2008，25，4： | 1 |
| 20 | Hyperhomocysteinemia and atherosclerosis显示文摘 | Yang F Tan HM Wang H | 2005 | Sheng Li Xue Bao2005，57，2： | 1 |
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