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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract显示文摘 | Chan LN Tsang LL Rowlands DK | 2002 | J Membr Biol2002，185，： | 1 |
| 3 | Molecular detection of a novel human influenza (H1N1) of pandemic potential by eonven- tional and real-time quantitative RT-PCR assays显示文摘 | Pooh LL Chan KH Smith GJ | 2009 | Clin Chem2009，55，8： | 1 |
| 4 | Imaging of mucormycosis skull base osteomyelitis显示文摘 | Chan LL Singh S | 2000 | AJNR2000，21，5： | 1 |
| 5 | Biliary cystadenoma and cystadenocarcinorna:some unusual feature显示文摘 | Cheung YK Chan FI Leong LL | 1991 | Clin Radiol1991，43，： | 1 |
| 6 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 7 | Temporal lobe necrosis in nasopharyngeal cacinoma pictorial essay显示文摘 | Chong VFH Fan YF Chan LL | 1997 | Austral Radiol1997，41，3： | 1 |
| 8 | Monophasic, solitary tumoefactive demylinating lesion: neuroimaing features and neuropathologiealdiangnosis显示文摘 | Tan HM Chan LL Chuah KI | 2004 | BrJradiol2004，7，： | 1 |
| 9 | A Biomechanical Comparison of Fan-Folded,Single-Looped Fascia Lata With Other Graft Tissues as a Suitable Substitute for Anterior Cruciate Ligament Reconstruction显示文摘 | Chan DB Temple HT Latta LL | 2010 | The Journal of Arthroscopic&Related Surgery2010，26，12： | 1 |
| 10 | AroleforSTAT3 and cathepsin S in Ⅱ_10 down-regulation of IFN-gamma-indueed MHC class Ⅱ molecule on primary human blood macrophages 显示文摘 | Chan LL CheungBK LiJC etal | 2010 | J Leukoc Biol2010，88，2： | 1 |
| 11 | Evaluation of real-time reverse transcriptase PER and real-time loop-mediated amplification assays for severe acute respiratory syndrome cororlavirus detection显示文摘 | Pooh LL Wong BW Chan KH | 2005 | J Clin Microbiol2005，43，7： | 1 |
| 12 | Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays 显示文摘 | Poon LL Chan KH Smith GJ Leung CS Guan Y Yuen KY Peiris JS | 2009 | Clin Chem2009，55，8： | 1 |
| 13 | Long-term improvement in homocystein levels and arterial endothelial function after 1-year folic acid supplementation显示文摘 | Woo KS Chook P Chan LL Cheung AS Fung WH Oiao M | 2002 | Am J Med2002，112，7： | 1 |
| 14 | Natural killer cell malignancies:clinicopathologic and molecular features显示文摘 | Siu LL Chan JK Kwong YL | 2002 | Histol Histopathol2002，17，2： | 1 |
| 15 | Diabetes-induced apoptosis in rat kidney显示文摘 | Zhang W Khanna P Chan LL | | 0，，01： | 1 |
| 16 | Real-time kinematic spans the gap显示文摘 | WONG KY MAN LL CHAN WY | 2001 | GPS World2001，12，7： | 1 |
| 17 | Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folio acid supplementation 显示文摘 | Woo KS Chook P Chan LL | 2002 | Am J Med2002，112，7： | 1 |
| 18 | Detection of SARS coronavirus in patients with suspected SARS显示文摘 | Chan KH Poon LL Cheng VC | 2004 | Emerg Infect Dis2004，10，2： | 1 |
| 19 | Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimentalendotoxemia显示文摘 | Chan JY Chang AY Wang LL | 2007 | Mol Pharmacol2007，71，4： | 1 |
| 20 | Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus显示文摘 | Yam WC Chan KH Poon LL | 2003 | J Clin Microbiol2003，41，10： | 1 |
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