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| 1 | Selective Mimics of Strigolactone Actions and Their Potential Use for Controlling Damage Caused by Root Parasitic Weeds显示文摘Strigolactones (SL ) 是植物荷尔蒙和根围通讯信号的一个新奇的类,尽管位于他们的活动下面的分子的机制还没是充分坚定的。他们的应用程序也不在很好开发的农业。植物荷尔蒙收缩筋的重要性在基本、适用的研究被表明了,并且模仿 strigolactone 功能的化学药品应该极大地便于 strigolactone 研究。这里,我们报导我们新 phenoxyfuranone 混合物的发现, 4-Br debranone (4BD ) ,那显示出类似的活动到主要 strigolactone (SL ) 的在植物上的生物试金的许多方面的模拟 GR24。4BD 强烈在象 GR24 的一样的集中在 SL 缺乏的米饭异种 d10 禁止了 tiller 芽长出,没有不利效果,甚至在延长耕作期间。这结果也在 Arabidopsis thaliana 被观察 SL 缺乏的异种 max1, max3,和 max4。然而,到 Arabidopsis SL 感觉迟钝的变异的 max2 的 4BD 的应用程序没在它导致词法变化。SL biosynthetic 基因的表示被 4BD 处理也减少,可能经由否定反馈规定。然而在 Striga hermonthica 上的种子萌芽试金,一条根寄生植物, 4BD 远比 GR24 显示出更少的活动。这些结果建议 4BD 是第一植物特定的 strigolactone 模仿。 | Kosuke Fukui Shinsaku Ito Tadao Asami | 2013 | Molecular Plant2013，6，1： | 9 |
| 2 | Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis显示文摘AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH).METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated.RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18expression and HOMA-R were signifi cantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. | Mitsuteru Kitade Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yusaku Shirai Masaharu Yamazaki Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Masayoshi Sawai Motoyuki Yoshida Chie Morioka Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2009 | World Journal of Gastroenterology2009，15，41： | 9 |
| 3 | Combined treatment of vitamin K_2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis显示文摘Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC. | Hitoshi Yoshiji Ryuichi Noguchi Masaharu Yamazaki Yasuhide Ikenaka Masayoshi Sawai Masatoshi Ishikawa Hideto Kawaratani Tsuyoshi Mashitani Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，23： | 5 |
| 4 | Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: A case report显示文摘Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rares. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides . Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection. | Kosuke Kaji Hitoshi Yoshiji Masahide Yoshikawa Masaharu Yamazaki Yasuhide Ikenaka Ryuichi Noguchi Masayoshi Sawai Masatoshi Ishikawa Tsuyoshi Mashitani Mitsuteru Kitade Hideto Kawaratani Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，27： | 3 |
| 5 | Interferon augments the anti-fibrotic activity of an angiotensin-converting enzyme inhibitor in patients with refractory chronic hepatitis C显示文摘AIM: To evaluate the effect of combination treatment with the interferon (IFN) and angiotensin-converting enzyme inhibitor (ACE-Ⅰ) on several fibrotic indices in patients with refractory chronic hepatitis C (CHC). METHODS: Perindopril (an ACE-Ⅰ; 4 mg/d) and/or natural IFN (3 MU/L; 3 times a week) were administered for 12 mo to refractory CHC patients, and several indices of serum fibrosis markers were analyzed. RESULTS: ACE-Ⅰdecreased the serum fibrosis markers, whereas single treatment with IFN did not exert these inhibitory effects. However, IFN significantly augmented the effects of ACE-Ⅰ, and the combination treatment exerted the most potent inhibitory effects. The serum levels of alanine transaminase and HCV-RNA were not significantly different between the groups, whereas the plasma level of transforming growth factor-b was significantly attenuated almost in parallel with suppression of the serum fibrosis markers. CONCLUSION: The combination therapy of an ACE- Ⅰand IFN may have a diverse effect on disease progression in patients with CHC refractory to IFN therapy through its anti-fibrotic effect. | Hitoshi Yoshiji Ryuichi Noguchi Hideyuki Kojima Yasuhide Ikenaka Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Masaharu Yamazaki Masahisa Toyohara Akira Mitoro Hiroshi Fukui | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 6 | Attenuation of insulin-resistance-based hepatocarcinogenesis and angiogenesis by combined treatment with branched-chain amino acids and angiotensin-converting enzyme inhibitor in obese diabetic rats显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Kosuke Kaji Yasuhide Ikenaka Yusaku Shirai Tadashi Namisaki Mitsuteru Kitade Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2010 | Journal of Gastroenterology2010，，4： | 1 |
| 7 | Combination of branched-chain amino acid and angiotensin?convertingenzyme inhibitor improves liver fibrosis progression in patients with cirrhosis显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yosuke Aihara Akitoshi Douhara Junichi Yamao Masahisa Toyohara Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Chie Morioka Masao Fujimoto Masahito Uemura Hiroshi Fukui | 2012 | Molecular Medicine Reports2012，，： | 1 |
| 8 | Branched-chain amino acids suppress insulin-resistance-based hepatocarcinogenesis in obese diabetic rats显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Mitsuteru Kitade Kosuke Kaji Yasuhide Ikenaka Tadashi Namisaki Junichi Yoshii Koji Yanase Masaharu Yamazaki Tatsuhiro Tsujimoto Takemi Akahane Hideto Kawaratani Masahito Uemura Hiroshi Fukui | 2009 | Journal of Gastroenterology2009，，5： | 1 |
| 9 | Combination of branched-chain amino acids and angiotensin-convertingenzyme inhibitor suppresses the cumulative recurrence of hepatocellular carcinoma:A randomized control trial显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yosuke Aihara Masaharu Yamazaki Junichi Yamao Masahisa Toyohara Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Chie Morioka Masao Fujimoto Masahito Uemura Hiroshi Fukui | 2011 | Oncology Reports2011，，6： | 1 |
| 10 | Attenuation of insulin-resistance-based hepatocarcinogenesis and angiogenesis by combined treatment with branched-chain amino acids and angiotensin-converting enzyme inhibitor in obese diabetic rats显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Kosuke Kaji Yasuhide Ikenaka Yusaku Shirai Tadashi Namisaki Mitsuteru Kitade Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2010 | Journal of Gastroenterology2010，，4： | 1 |
| 11 | A case of severe acalculous cholecystitis associated with sorafenib treatment for advanced hepatocellular carcinoma显示文摘Sorafenib,a multikinase inhibitor,is the first and only drug,which improves significantly the overall survival in patients with advanced hepatocellular carcinoma(HCC).However,many patients experience diverse side effects,some of them severe and unexpected.To date,acute acalculous cholecystitis has not been documented in association with a HCC patient treated with sorafenib.Here,we report the case of a 43-yearold woman with hepatitis C virus-related advanced HCC.She received sorafenib,and later complained ofa sudden onset of severe right hypocondrial pain with rebound tenderness and muscle defense.Laboratory examination showed mild elevation of transaminases,biliary enzymes,bilirubin,inflammation markers,and a marked peripheral eosinophilia.Abdominal computed tomography(CT) revealed a swollen gallbladder with exudate associated with severe inflammation without stones or debris.Consequently,sorafenib treatment was stopped immediately,and steroid-pulse therapy was performed.Steroid therapy drastically improved all clinical manifestations along with normalization of CT findings,eosinophilia,and liver functions.In summary,we herein report a rare case of acute severe acalculous cholecystitis associated with sorafenib in the patient with advanced HCC. | Yosuke Aihara Hitoshi Yoshiji Masaharu Yamazaki Yasuhide Ikenaka Ryuichi Noguchi Chie Morioka Kosuke Kaji Haruki Tastumi Keisuke Nakanishi Maiko Nakamura Junichi Yamao Masahisa Toyohara Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Masao Fujimoto Masahito Uemura Hiroshi Fukui | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 1 |
| 12 | Reduction of endotoxin attenuates liver fibrosis through suppressionof hepatic stellate cell activation and remission of intestinal permeability ina rat non-alcoholic steatohepatitis model显示文摘 | Akitoshi Douhara Kei Moriya Hitoshi Yoshiji Ryuichi Noguchi Tadashi Namisaki Mitsuteru Kitade Kosuke Kaji Yosuke Aihara Norihisa Nishimura Kosuke Takeda Yasushi Okura Hideto Kawaratani Hiroshi Fukui | 2015 | Molecular Medicine Reports2015，，3： | 1 |
| 13 | Direct renin inhibitor, aliskiren, attenuates the progression of non‐alcoholic steatohepatitis in the rat model显示文摘 | Yosuke Aihara Hitoshi Yoshiji Ryuichi Noguchi Kosuke Kaji Tadashi Namisaki Yusaku Shirai Akitoshi Douhara Kei Moriya Hideto Kawaratani Hiroshi Fukui | 2013 | Hepatol Res2013，，11： | 1 |
| 14 | On improving strigolactone mimics for induction of suicidal germination of the root parasitic plant Striga hermonthica显示文摘Strigolactones(SLs)are plant hormones that regulate the branching of plants and seed germination stimulants of root parasitic plants.As root parasites are a great threat to agricultural production,the use of SL agonists could be anticipated to provide an efficient method for regulating root parasites as suicidal germination inducers.A series of phenoxyfuranone-type SL mimics,termed debranones,has been reported to show potent bioactivities,including reduction of the tiller number on rice,and stimulation of seed germination in the root parasite Striga hermonthica.To exert both activities,two substituents on the phenyl ring of the molecules were important but at least a substituent at the 2-position must be an electron-withdrawing group.However,little is known about the effect of the properties of the substituents at the 2-position on bioactivities.Here,we found that different substituents at the 2-position give different preferences for bioactivities.Halogenated debranones were more effective than the others and SL agonist GR24 for inhibiting rice tiller but far less effective in the induction of S.hermonthica germination.Meanwhile,nitrile and methyl derivatives clearly stimulated the germination of S.hermonthica seeds.Although their IC_(50) values were 100 times higher than that of GR24 in the receptor competitive binding assay,their physiological activities were approximately 1/10 of GR24.These differences could be due to their uptake in plants and/or their physicochemical stability under our experimental conditions.These findings could support the design of more potent and selective SL agonists that could contribute to solving big agricultural issues. | Ikuo Takahashi Kosuke Fukui Tadao Asami | 2021 | aBIOTECH2021，2，1： | 0 |
| 15 | Eosinophilic cholecystitis as a rare manifestation of visceral larva migrans显示文摘Eosinophilic cholecystitis is an infrequent form of cholecystitis. The etiology of eosinophilic cholecystitis is still obscure, and it is sometimes accompanied with several complications, but a simultaneous onset with pericarditis is very rare. We would like to make an alternative interpretation of our recent report 'Kaji K, Yoshiji H, Yoshikawa M, Yamazaki M, Ikenaka Y, Noguchi R, Sawai M, Ishikawa M, Mashitani T, Kitade M, Kawaratani H, Uemura M, Yamao J, Fujimoto M, Mitoro A, Toyohara M, Yoshida M, Fukui H. Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: A case report. World J Gastroenterol 2007; 13: 3760-3762.' | Hitoshi Yoshiji Masahide Yoshikawa Kosuke Kaji Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，45： | 0 |
| 16 | Cholangiocarcinoma developed in a patient with IgG4-related disease显示文摘A 77-year-old man with jaundice and a pancreatic head tumor was referred to our hospital in August2006.The initial laboratory tests,computed tomography(CT)scan,magnetic resonance imaging(MRI),and endoscopic retrograde cholangiopancreatography suggested IgG4-related cholangitis and autoimmune pancreatitis.Oral prednisolone(PSL)was then administered.This treatment reduced the size of the pancreatic parenchyma,and the lower common bile duct(CBD)returned to its normal size.Thus,the oral PSL was gradually tapered to a maintenance dose.In February 2010,a CT scan and MRI showed segmental wall thickening and stenosis of the middle CBD,the progression of which led to extrahepatic obstructive jaundice.We suspected the emergence of a cholangiocarcinoma rather than the exacerbation of the IgG4-related sclerosing cholangitis because the stricture of the CBD was short and localized.Then,a percutaneous transhepatic biliary drainage was performed.The biopsy specimens obtained via the percutaneous transhepatic tract indicated an abnormal glandular formation,suggesting the presence of a moderate,well-differencated adenocarcinoma.The gross examination,microscopic examination and immunohistochemical analysis of the pancreaticoduodenectomy specimen suggested that a cholangiocarcinoma developed from the IgG4-related sclerosing cholangitis. | Akitoshi Douhara Akira Mitoro Emi Otani Masanori Furukawa Kosuke Kaji Masakazu Uejima Masayoshi Sawai Motoyuki Yoshida Hitoshi Yoshiji Junichi Yamao Hiroshi Fukui | 2013 | World Journal of Gastrointestinal Oncology2013，5，8： | 0 |
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