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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Phase HI study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma显示文摘 | Tada F Abe M Hirooka M | 2012 | Int J Oncol2012，41，： | 1 |
| 3 | Phase I/II study of immunotherapy using tumor antigen - pulsed dendritic cells in patients with hepatocellular carcinoma 显示文摘 | Tada F Abe M Hirooka M | 2012 | Int J Oncol2012，41，5： | 1 |
| 4 | Characteristics of familial breast cancer显示文摘 | Tada T Kasumi F | | 0，，07： | 1 |
| 5 | Development of stip- off biopsy显示文摘 | Tada M Shimada H Murakami F | 1984 | Gastroenterol Endosc1984，26，2： | 1 |
| 6 | Abnormal activity in the globus pallidus in off-period dystonia显示文摘 | Tada T Nakazato F | 2001 | Ann Neurol2001，49，： | 1 |
| 7 | Spatial learning transiently disturbed by intraventricular administration of ouabain显示文摘 | Zhan H Tada T Nakazato F | 2004 | Neurol Res2004，26，1： | 1 |
| 8 | Characteristics of familial breast cancer显示文摘 | Tada T Kasumi F | 2000 | Nippon Riusho2000，58，7： | 1 |
| 9 | Gain of GRHL2 is associated with ear-ly recurrence of hepatocellular carcinoma显示文摘 | Tanaka Y Kanai F Tada M Tateishi R Sanada M Nannya Y | 2008 | J Hepa-tol2008，49，： | 1 |
| 10 | Organic hybrid of chlorinated polyet hytene and hindered phenoll:Dyn- amic mechanical properties显示文摘 | WU C F TADA Y YOSHIAKI N | 2000 | Polym Sci Part B:Polym Phys2000，38，17： | 1 |
| 11 | Occurrence of paralytic shellfish toxins in Cambodian Mekong pufferfish Tetraodon turgidus:selective toxin accumulation in the skin显示文摘 | NGY L TADA K YU C F | 2008 | Toxicon2008，51，： | 1 |
| 12 | Disturbed spatial learning of rats after intraventricular administration of transforming growth factor-beta 1显示文摘 | Nakazato F Tada T Sekiguchi Y | 2002 | Neurol Med Chir (Tokyo)2002，42，4： | 1 |
| 13 | Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma显示文摘 | Tada F Abe M Hirooka M | | 0，，05： | 1 |
| 14 | Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma显示文摘 | Tada F Abe M Hirooka M | | 0，，05： | 1 |
| 15 | Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes显示文摘 | MIURA M TADA H YASUI F N | 2004 | Eur J Clin Pharmacol2004，60，： | 1 |
| 16 | Phase I / II study of immuno-therapy using tumor antigen-pulsed dendritic cells in patients withhepatocellular carcinoma 显示文摘 | Tada F Abe M Hirooka M | 2012 | Int J Oncol2012，41，5： | 1 |
| 17 | 5-aza-2' -deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines 显示文摘 | KANDA T TADA M IMAZEKI F | 2005 | Oncol Rep2005，14，4： | 1 |
| 18 | Rice SPK, a calmodulin - like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor显示文摘 | Asano T Kunieda N Omura Y Ibe H Kawasaki T Takano M Sato M Furuhashi H Mujin T Takalwa F Wu C Y Tada Y Satozawa T Sakamoto M Shimada H | 2002 | Plant Cell2002，14，： | 1 |
| 19 | Phase I / II study of immunotherapy using tumor antigen-pulsed dendritic ceils in patients with hepatocellular carcinoma 显示文摘 | Tada F Abe M Hirooka M | 2012 | Int J Oncol2012，41，5： | 1 |
| 20 | A new approach to the observation of minute changes of the colonic mucosa by means of magnifying colonoscope, type CF-MB-M ( olympus ) 显示文摘 | Tada M Misaki F Kawai K | 1978 | Gastrointest Endosc1978，24，： | 1 |
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