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| 1 | Dietary and socio-economic factors in relation to Helicobacter pylori re-infection显示文摘AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the past.Patients were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection. | Mirosaw Jarosz Ewa Rychlik Magdalena Siuba Wioleta Respondek Magorzata Ryzko-Skiba Iwona Sajór Sylwia Gugaa Tomasz Bazejczyk Janusz Ciok | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | 应变速率和晶体包裹体对大块非晶和部分结晶的Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_5合金力学性能的影响(英文)显示文摘研究Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_5合金的力学性能,着重研究应变速率和晶体包裹体对合金变形和断裂机制的影响。X射线衍射分析表明,低氧含量时形成完全非晶态的合金组织,而当氧含量较高时,形成部分晶化组织;但是观察到完全不同的压缩变形行为。单轴压缩试验表明,全非晶合金具有弹性变形、屈服、明显塑性变形和锯齿流变行为。当应变速率从1×10^(-4) s^(-1)增加到1×10^(-2) s^(-1)时,屈服强度没有变化,然而,压缩断裂强度和塑性应力均降低。扫描电镜(SEM)和能谱(EDS)分析表明,即使在低氧含量的合金中,依然存在金属间化合物相CuZr_2,从而降低了合金的断裂强度和韧性。结果还证实在高氧含量的样品中存在枝晶状的Zr_(51)Cu_(28)Al_(21)相,会进一步降低其断裂强度。在断口表面可观察到韧性试样和脆性试样之间的差异。塑性应变越大,变形过程中形成的剪切带的密度越高,表现为应力-应变曲线上的锯齿流变行为。 | Tomasz KOZIE? Krzysztof PAJOR Grzegorz CIOS Piotr BA?A | 2019 | Transactions of Nonferrous Metals Society of China2019，29，5： | 3 |
| 4 | Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing显示文摘Localized surface plasmon resonance(LSPR)biosensing based on supported metal nanoparticles offers unparalleled possibilities for high-end miniaturization,multiplexing and high-throughput label-free molecular interaction analysis in real time when integrated within an opto-fluidic environment.However,such LSPR-sensing devices typically contain extremely large regions of dielectric materials that are open to molecular adsorption,which must be carefully blocked to avoid compromising the device readings.To address this issue,we made the support essentially invisible to the LSPR by carefully removing the dielectric material overlapping with the localized plasmonic fields through optimized wet-etching.The resulting LSPR substrate,which consists of gold nanodisks centered on narrow SiO2 pillars,exhibits markedly reduced vulnerability to nonspecific substrate adsorption,thus allowing,in an ideal case,the implementation of thicker and more efficient passivation layers.We demonstrate that this approach is effective and fully compatible with state-of-the-art multiplexed real-time biosensing technology and thus represents the ideal substrate design for high-throughput label-free biosensing systems with minimal sample consumption. | Srdjan S Aćimović Hana Šípová Gustav Emilsson Andreas B Dahlin Tomasz J Antosiewicz Mikael Käll | 2017 | Light(Science & Applications)2017，6，1： | 3 |
| 5 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 6 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 7 | Antibacterial efficacy of nisinagainst multidrug-resistant Grampositive pathogens 显示文摘 | SEVERINA E SEVERIN A TOMASZ A | 1998 | J Antimicrob Chemoth1998，41，： | 1 |
| 8 | CD1 4 is a pattern recognition receptor显示文摘 | Pugin J Heumann ID Tomasz A | 1994 | Immunity1994，1，6： | 1 |
| 9 | Methicillin-resistance Staphylococcus aureus isolates recovered from a New York city hospital :analysis by molecular fingerprinting techniques显示文摘 | de Lencastre H de Lencastre A Tomasz A | 1996 | J Clin Microbiol1996，34，9： | 1 |
| 10 | The challenge of antibiotic resistant bacterial pathogens: the medical need, the market and prospects for new antimierobial agents显示文摘 | Payne D Tomasz A | 2004 | Curr Opin Microbiol2004，7，5： | 1 |
| 11 | Decreased susceptibilities to teicoplanin and vancomycin among coagulase-negative methicillin-resistant clinical isolates of Staphylococci 显示文摘 | Sieradzki K Villari P Tomasz A | 1998 | J Antimicrob Agents Chemother1998，42，1： | 1 |
| 12 | Expression of metbicillin resistance in heterogeneous strains of Staphylococcus aureus显示文摘 | Hartman BJ Tomasz A | 1986 | Anti- microb Agents Chemother1986，，26： | 1 |
| 13 | Antibacterial efficary of nisin against multidrug-resistant Gram-positive pathogens显示文摘 | Severina E Severin A Tomasz A | 1998 | J Antimicrab Chemother1998，41，3： | 1 |
| 14 | Role of penicillin-binding protein 2(PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus:evidence for the cooperative functioning of PBP2,PBP4,and PBP2A显示文摘 | eski TA Tomasz A | 2005 | J Bacteriol2005，187，5： | 1 |
| 15 | The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth 显示文摘 | Tuomanen E Cozens R Tosch W Zak O Tomasz A | 1986 | J Gen Microbiol1986，132，5： | 1 |
| 16 | Antibiotic tolerance among clinical isolates of bacteria 显示文摘 | Tuomanen E Durack DT Tomasz A | 1986 | Antimicrob AgentsChemother1986，30，4： | 1 |
| 17 | Antibiotic resistance in Streptococcus Pneumoniae显示文摘 | Tomasz A | 1997 | Clirt Infect Dis1997，，： | 1 |
| 18 | Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Stapyulococcus aureus显示文摘 | Sieradzki K Tomasz A | 1997 | J Bacteriol1997，179，8： | 1 |
| 19 | Antibacterial efficiacy of nisin against multdrug-resistant Gram-positive pathogens显示文摘 | Severina E Severin A Tomasz A | 1998 | J Antimicrob Chemother1998，41，： | 1 |
| 20 | Inactivated pbp4 in highly glycopeptide-resistant laboratory mutants of Staphylococcus aureus显示文摘 | Sieradzki K Pinho MG Tomasz A | 1999 | J Biol Chem1999，274，18： | 1 |
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