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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection: Time Trends in a Spanish Multicenter Study of 1000 Patients显示文摘 | Javier P. Gisbert ángeles Pérez-Aisa Fernando Bermejo Manuel Castro-Fernández Pedro Almela Jesús Barrio ángel Cosme Inés Modolell Felipe Bory Miguel Fernández-Bermejo Luis Rodrigo Jesús Ortu?o Pilar Sánchez-Pobre Sam Khorrami Alejandro Franco Albert Tomas | 2013 | Journal of Clinical Gastroenterology2013，，2： | 5 |
| 3 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 4 | Insulin-like growth Factor- Ⅰ (IGF- Ⅰ ) and especially IGF- Ⅰ variants are anabolic in dexamethasone-treated rat显示文摘 | Tomas F M Knowles S E Owens P C | 1992 | Biochem J1992，282，： | 1 |
| 5 | Surface plasmon-coupled emission on plasmonic bragg gratings显示文摘 | TOMA M TOMA K ADAM P | 2012 | Optics Express2012，20，14： | 1 |
| 6 | Mechanisms of immunotherapy in allergic rhinitis显示文摘 | Jayasekera N P Toma T P Williams A | 2007 | Biomed Pharmacother2007，61，1： | 1 |
| 7 | Expression of c-kit in human osteosarcoma and its relevance as a prognostic parameter显示文摘 | Sulzbacher I Birner P Toma C | 2007 | J Clin Pathol2007，60，7： | 1 |
| 8 | Differentiation-related expression of the Thomsen-Friedenreich glycotope in developing human lung and in lung carcinoma:lack of association with malignancy显示文摘 | Toma V Sata T Vogt P | 1999 | Cancer1999，85，10： | 1 |
| 9 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 10 | Bronchoscopic lung vol- ume reduction for end-stage emphysema: report on the first 98 patients显示文摘 | Wan I Y Toma T P Geddes D M | 2006 | Chest2006，129，： | 1 |
| 11 | Themo-dynamic optimization of the Ni-Zn system显示文摘 | GEORGE P VASSILEV TOMAS G A | 2000 | J Phase Equilibria2000，21，3： | 1 |
| 12 | Cardiac involvement in genetically confirmed facioscapulohumeral muscular dystrophy显示文摘 | Laforet P de Toma C Eymard B | 1998 | Neurology1998，51，： | 1 |
| 13 | Fine mapping of an immunodominant region of the transmembrane protein of the human immunodefieieney virus (HIV-1)显示文摘 | Sven-Holger D Tomas P Peter H | 1989 | J Virol Method1989，25，2： | 1 |
| 14 | Role of desmoplasia in recurrence of stage Ⅱ coloreetal cancer within five years after surgery and therapeutic implicatian显示文摘 | Crispino P De Toma G Ciardi A | 2008 | Cancer Invest2008，26，4： | 1 |
| 15 | Oxidative elimination of cyanotoxins : comparison of ozone, chlorine, chlorine dioxide and permanganate显示文摘 | RODRIGUEZ EVA ONSTAD GRETCHEN D KULL TOMAS P J | 2007 | Water Research2007，41，15： | 1 |
| 16 | Glycolipids areinvolved in biofilm accumulation and prolonged bacteraemia in Enterococcus facealis显示文摘 | Theilacker C Sanchez-Carballo P Toma I | 2009 | Mol Microbiol2009，71，4： | 1 |
| 17 | Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epi- didymally derived white adipocyte cultures reveals a popula- tion of thermogenically competent, UCPl-containing adipocytes molecularly distinct from classic brown adipocytes 显示文摘 | Natasa P Tomas BW Irina GS | 2010 | J Biol Chem2010，285，10： | 1 |
| 18 | Characterization and photo- Fenton treatment of used tires leachate 显示文摘 | Judith S Tomas L Ormad P | 2006 | Journal of Hazardous Materials2006，136，1： | 1 |
| 19 | Contral of gonadotropin rdease in the Atlantic croaker (Macropogonias undulatus) Evidence for a lack of dopaminergic inhibition 显示文摘 | Copeland P A Tomas P | 1989 | Gen Comp Endocrinol1989，74，： | 1 |
| 20 | Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker显示文摘 | Sulzbacher I Birner P Toma C | | 0，，07： | 1 |
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