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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 3 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 4 | Apoptosis and necrosis: Detection, discrimination and phagocytosis显示文摘 | Dmitri V. Krysko Tom Vanden Berghe Katharina D'Herde Peter Vandenabeele | 2008 | Methods2008，，3： | 2 |
| 5 | 胶管胶带用硫化剂和防老剂显示文摘越来越高的汽车发动机温度对在汽车中使用的胶管和胶带用聚合物提出了更严格的要求。本文综述了胶管和胶带中使用的聚合物,并针对提高耐热、耐屈挠疲劳和耐臭氧老化性能讨论了每一种聚合物用的硫化体系和防老剂搭配。 | Sinha D P Jablonowski Tom Ohm Bob Vanis Vern 黄向前 | 2002 | 橡胶工业2002，49，12： | 2 |
| 6 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 7 | Optimizing an integrated membrane system for municipial wastewater treatment 显示文摘 | Tom K William D | 2008 | Desalina- tion2008，2，1： | 1 |
| 8 | Mesh optimization显示文摘 | HUGUES H TONY D TOM D | 1994 | Computer Aided Geometric Design1994，11，2： | 1 |
| 9 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 10 | Comparison of Plasma comartment versus two methods for effect compartment-controlled targetcontrolled infusion for propofol显示文摘 | STRUYS M R TOM D S BIRGIE D | 2000 | Ansthesiology2000，92，： | 1 |
| 11 | Epidermal growth factor-expressing Lactococcus lactis enhances intestinal development of early-weaned pigs显示文摘 | KANG P TOMS D YIN Y L | 2010 | The Journal of Nutrition2010，140，4： | 1 |
| 12 | Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease 显示文摘 | SANTIAGO R TOM R G IAN N M D | 2007 | Hum Genet2007，122，： | 1 |
| 13 | Quality assurance of a helical tomotherapy machine显示文摘 | J D Fenwick W A Tom'e H A Jaradat | 2004 | Phys Med Biol2004，，49： | 1 |
| 14 | Developmental validation of short tandem repeat reagent kit for forensic DNA profiling of canine biological material 显示文摘 | Dayton M Koskinen MT Tom BK Mattila A-M Johnston E Halverson J Fantin D Denise S Budowle B Smith DG Kan- thaswamy S | 2009 | Croatian Medical Journal2009，50，： | 1 |
| 15 | Piecewise regression:A tool for identifying ecological thresholds显示文摘 | Toms J D Lesperance M L | 2003 | Ecology2003，84，8： | 1 |
| 16 | EEG classification of imagined syllable rhythm using Hilbert spectrum methods 显示文摘 | Siyi D Ramesh S Tom L | 2010 | Journal of Neural Engineering2010，7，04： | 1 |
| 17 | Challenges, design and analysis of a large-scale p2p-vod system 显示文摘 | Huang Yah Fu Tom Z J Chiu D M | 2008 | ACM Sigtcomm Computer Communication Review2008，38，4： | 1 |
| 18 | Combining an au- tologous peripheral nervous system 'bridge' and matrix modi- fication by ehondroitinase, allows robust, functional regenera- tion beyond a hemisection lesion of the adult rat spinal cord 显示文摘 | HOULE J D TOM V J MAYES D | 2006 | Neurosci2006，26，28： | 1 |
| 19 | RIP kinases at the crossroads of cell death and survival 显示文摘 | Wim D Tom VB Peter V | 2009 | Cell2009，138，： | 1 |
| 20 | Controlling the Decoherence of a 'Meter',via stroboscopic feedback显示文摘 | VITALI D TOM BESI P MILBURN G J | 1997 | Phys Rev Lett1997，79，13： | 1 |
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