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| 1 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 2 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 3 | Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: a retrospective cohort study显示文摘BackgroundDisturbed 生理节奏的节奏是谵妄的一个潜在的原因并且被连接到生理节奏的 rhythmicity 的 disorganisation。动态光(DL ) 能由 suprachiasmatic 原子核的激活重设生理节奏的节奏阻止谵妄。关于轻治疗的效果的证据主要集中于精神病学的混乱和生理节奏的节奏睡觉混乱。在这研究,我们在停留(LOS ) 的全部的医院长度上调查了 DL 的效果,在病人的谵妄的出现承认 .MethodsThis 是回顾的队研究到联合起来的冠的照顾(CCU ) 。比 18 年老的病人,在 CCU 比 12 h 长被就医并且为至少 24 h 有全部的医院 LOS,被包括。病人们与 DL 被分到一个房间(n = 369 ) 或常规点亮条件(n = 379 ) 。DL 被与在 2700 和 6500 度凯尔文之间的颜色温度交付光的二块装天花板的轻面板在 CCU 管理。报导结果数据是:全部的医院 LOS,谵妄发生,一个老人病学者的会诊和 prescripted antipsychotics.ResultsBetween 2015 年 5 月和 2016 年 5 月的数量,从 748 个病人的数据被收集。包括挑起谵妄的风险因素,基线特征在两个组是相等的。在 DL 组的中部的全部的医院 LOS 是 100.5 (70.8-186.0 ) 并且 101.0 (73.0-176.4 ) 在控制组的 h (P = 0.935 ) 。在 DL 和控制组的谵妄的发生是 5.4%(20/369 ) 并且 5.0%(19/379 ) ,分别地(P = 0.802 ) 。DL 和控制组之间的重要差别都没在第二等的端点被观察。亚群分析也基于年龄和 CCU LOS 证明当一条早单个的途径不导致全部的医院 LOS 的减小或减少谵妄的发生,没有 differences.ConclusionOur 学习建议暴露到 DL。当谵妄被诊断时,它与差的医院结果被联系。 | Tobias Pustjens Antonius MC Schoutens Loes Janssen Wilfred F Heesen | 2018 | Journal of Geriatric Cardiology2018，15，9： | 2 |
| 4 | Assessing hydrological and provisioning ecosystem services in a case study in Western Central Brazil显示文摘Introduction:Current land use in the Federal District,Western Central Brazil,causes problems related to the water supply which are linked to the regulation of ecosystem services(ES).In scope of an Integrated Water Resources Management concept,we further developed the web-based planning support tool GISCAME for the Pipiripau river basin case study.Methods:We introduced analyses on ecosystem potentials in the raster-based tool to assess,in a spatially explicit manner,the scenario impact on water purification,sediment retention,water retention,and provision of food and fodder in order to identify potential pathways for conserving water resources.To demonstrate the method,we assess ES depending on a number of land use/land cover change(LULCC)scenarios.Results:We found that a considerable increase of water purification and sediment retention is difficult to achieve with realistic small scale LULCC,mainly because in areas with a low potential to provide hydrological ES and thus with a high demand for sustainable land use,such as native Savanna(Cerrado)and natural forests(Mata),favorable land uses were often already existing.We observed synergies in the response of regulating hydrological ES to LULCC but at the same time also trade-offs with provision of food and fodder.Conclusions:Our findings suggest that further degradation and loss of Cerrado and Mata must be avoided and their restoration should be promoted in order to safeguard water resources.We suggest that restoration measures should be focused on arable land located at steep slopes near surface waters to effectively increase hydrological ES through the marginal reduction of provision services. | Lars Koschke Carsten Lorz Christine Fürst Tobias Lehmann Franz Makeschin | 2014 | Ecological Processes2014，3，1： | 2 |
| 5 | A comprehensive urinary metabolomie approach for identifying kidney cancer显示文摘 | VLADIMIR T OLIVER F | 2007 | Anal Biochem2007，363，2： | 1 |
| 6 | Emotion and attention: event-related brain potential studies显示文摘 | HARALD T S TOBIAS F JESSICA S | 2006 | Progress in Brain Research2006，156，： | 1 |
| 7 | Hemibody Irradiation:an effect ive second-line therapy in drug-resistance multiple myeloma显示文摘 | Singer CR Tobias JS Giles F | 1989 | Cancer1989，63，12： | 1 |
| 8 | Affective prime and target picture processing: an ERP analysis of early and late interference effects 显示文摘 | TOBIAS F JESSICA S HARALDT S | 2008 | Brain Topography2008，20，： | 1 |
| 9 | Characterization of high-intensity sub-4-fs laser pul- ses using spatially encoded spectral shearing interfer- ometry显示文摘 | TOBIAS W FELIX F CHRISTOPHER A | 2011 | Optics Letters2011，36，9： | 1 |
| 10 | Hemodynamic Effects of Dex- medetomidine in Critically Ill Neonates and Infants With Heart Disease 显示文摘 | Lam F Bhutta AT Tobias JD | 2012 | Pediatr Cardiol2012，34，1： | 1 |
| 11 | The roh of rear surface in thin silicon solar cells显示文摘 | LLOPIS F TOBIAS I | 2005 | Solar Energy Materials and Solar Cells2005，87，14： | 1 |
| 12 | Hemodynamic Effects ofDexmedetomidine in critically III Neonates and Infants with HeartDisease 显示文摘 | Lam F Bhutta HT Tobias JD | 2012 | Pediatr cardiol2012，11，： | 1 |
| 13 | Harald,Experimental demonstration of free-space decoy-state quantum key distribution over 144km显示文摘 | Tobias S M Henning W Martin F | 2007 | Phys Rev Lett2007，98，01： | 1 |
| 14 | Wind turbine reliability analysis显示文摘 | PINAR PéREZ J M GARCíA MáRQUEZ F P ANDREW TOBIAS | 2013 | Renewable and Sustainable Energy Reviews2013，23，： | 1 |
| 15 | Evaluation of two commercial loopmediated isothermal amplification assays for detection of avian influenza H5 and H7 hemagglutinin genes显示文摘 | Alexander P Tobias L Sieghard F | 2010 | J Vet Diagn Invest2010，22，： | 1 |
| 16 | A critical analysis of the reported association between vasectomy and frontotemporal dementia显示文摘 | Tobias S K6hler Jeremy T Choy Anees A Fazili Joel F Koenig Robert E Brannigan | 2012 | Asian Journal of Andrology2012，14，6： | 1 |
| 17 | Color-coded perfused blood volume imaging using multidetector CT: initial results of whole-brain peffusion analysis in acute cerebral ischemia 显示文摘 | Stephan P Tobias F Darius G | 2007 | Eur Radiol2007，17，： | 1 |
| 18 | Rep and Rep' protein of porcine circovirus type 1 bind to the origin of replication in vitro显示文摘 | TOBIAS S TIM F ANNETI'E M | 2001 | Virol2001，291，1： | 1 |
| 19 | Soil microbial parameters and luminescent bacteria assays as indicators for in situ bioremedition of TNT-contaminated soils显示文摘 | TOBIAS F HEINRICH H | 2003 | Chemosphere2003，50，： | 1 |
| 20 | Alpine grassland phenology as seen in AVHRR, VEGETATION, and MODIS NDVI time series: A comparison with in Situ measurements显示文摘 | FABIO F CHRISTIAN R TOBIAS J | 2008 | Sensors2008，8，4： | 1 |
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