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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women显示文摘 | Thomas T Burguera B Melton III LJ | 2001 | Bone2001，29，： | 1 |
| 3 | Vaccine induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis 显示文摘 | RITTERSHAUS CW MILLER DP THOMAS LJ | 2000 | Arterioscler Thromb Vasc Biol2000，20，2： | 1 |
| 4 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 5 | Hydrophobic Strip-of-helix algorithm for selection of T cell-presented peptides 显示文摘 | Stille CJ Thomas LJ Reyes VE | 1987 | Mol Immunol1987，24，10： | 1 |
| 6 | Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis显示文摘 | Rittershaus CW Miller DP Thomas LJ | 2000 | Arteriascler Thromb Vasc Biol2000，20，9： | 1 |
| 7 | Sensitive detection of the effects of reperfusion on myocardium by ultrasonic tissue characterization with integrated backscatter显示文摘 | Thomas Ⅲ LJ Miller JG | 1986 | Circulation1986，74，： | 1 |
| 8 | Sensitive detection of the effects of reperfusion on myocardium by ultrasonic tissue characterization with integrated backscatter显示文摘 | Wickline SA Thomas LJ 3rd Miller JG | 1986 | Circulation1986，74，2： | 1 |
| 9 | The dependence of myocardial ultrasonic integrated backscatter on contractile performance显示文摘 | Thomas III LJ Miller JG | 1985 | Circulation1985，72，： | 1 |
| 10 | Recombinant glycoproteins that inhibit complement activation and also bind the selectin adhesion molecules显示文摘 | Ritterhaus CW Thomas LJ Miller DP | 1999 | Biol Chem1999，274，11： | 1 |
| 11 | Proteolytic cleavage of Ii to p25显示文摘 | Thomas LJ Nguyen QV Elliott WL | 1988 | J Immunol1988，140，8： | 1 |
| 12 | Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women显示文摘 | Thomas T Burguera B Melton LJ | 2001 | Bone2001，29，： | 1 |
| 13 | Estrogen levels do not correlate with improvement in cognition显示文摘 | Thal LJ Thomas RG Mulnard R | 2003 | Arch Neurol2003，60，： | 1 |
| 14 | The clependence of myocardial ultrasonic integrated backscatter on contracfile performance显示文摘 | Wickline SA Thomas III LJ Miller JG | 1985 | Circulation1985，72，： | 1 |
| 15 | Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries显示文摘 | Leurs LJ Bell R Degrieck Y Thomas S | 2004 | J Vase Surg2004，40，4： | 1 |
| 16 | The PINK1lPark in pathway regulates mitochondrial morphology显示文摘 | Poole AC Thomas RE Andrews LA McBride HM Whitworth A J Pallanck LJ | 2008 | Proc Natl Acad Sci USA2008，105，5： | 1 |
| 17 | Vitamin E and donepezil for the treatment of mild cognitive impairment显示文摘 | Petersen RC Thomas RG Grundman M Bennett D Doody R Ferris S Galasko D Jin S Kaye J Levey A Pfeiffer E Sano M van Dyck CH Thal LJ Alzheimer's Disease Cooperative Study Group | | 0，，23： | 1 |
| 18 | Effectiveness of universal pre-enrichment broth for recovery of Salmonella from selected dairy foods显示文摘 | Thomas SH Amaguana RM Mildred LJ | 2003 | J AOAC Int2003，86，： | 1 |
| 19 | Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women显示文摘 | Thomas T Burguera B Melton LJ | 2001 | Bone2001，29，： | 1 |
| 20 | Cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment resistant depression in primary care:the CoBalT randomised controlled trial protocol 显示文摘 | Thomas LJ Abel A Ridgway N | 2012 | Contemp Clin Trials2012，33，2： | 1 |
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