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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 4 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 5 | Methods in laboratory investigation normal human urothelial cells in vitro: proliferation and induction of stratification显示文摘 | Southgate J Hutton K A R Thomas D F M | 1994 | Lab Invest1994，71，4： | 2 |
| 6 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 7 | Preparation and surface properties of acrylic polymers containing fluorinated monomers 显示文摘 | Richard R Thomas D R Anton W F | 1997 | Macromolecules1997，30，： | 1 |
| 8 | Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation显示文摘 | THOMAS R B DAVID L M GUO R F | 2005 | Oncogene2005，24，15： | 1 |
| 9 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 10 | Safety, feasibility, and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation 显示文摘 | Gupta R Al-Ali F Thomas AJ | 2006 | Stroke2006，37，10： | 1 |
| 11 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 12 | Sampling errors in the estimation of empirical orthogonal functions显示文摘 | North G B Thomas L B Cahalan R F | 1982 | Men Wen Bey1982，110，： | 1 |
| 13 | The environmental fate of phthalate esters:a literature review显示文摘 | Charles A S Dennis R P Thomas F P | 1997 | Chemesphere1997，35，4： | 1 |
| 14 | Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow 显示文摘 | Thomas S N Zhu F Schnaar R L | 2008 | J Biol Chem2008，283，15： | 1 |
| 15 | Surgery versus radiation theapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles 显示文摘 | NUYTTENS J J RUST P F THOMAS J R C R | 2000 | Cancer2000，88，： | 1 |
| 16 | Radiofrequency ablation in patients with primary breast carcinoma: a pilot study in 26 patients显示文摘 | Izzo F Thomas R Delrio P | 2001 | Cancer2001，92，8： | 1 |
| 17 | Reductions in the productivity of oil and low permeability gas reservoirs due to aque- ous phase trapping 显示文摘 | Bennion D B Bietz R F Thomas F B | 1994 | Journal of Crgstallization Process and Tech- nology1994，33，8： | 1 |
| 18 | Aurantiamine, a diketopiperazine from two varieties of Penicilium aurantiogriseum 显示文摘 | Thomas O L Jens C F Soren R J | 1992 | Phytochemistry1992，31，5： | 1 |
| 19 | Experimental investiga- tion of the confluent boundary layer of a high-lift system 显示文摘 | Thomas F O Nelson R C Liu X | 2000 | AIAA Journal2000，38，6： | 1 |
| 20 | The environmental fate of pbthalate esters-a literature review显示文摘 | CHARLES A S DENNIS R P THOMAS F P | 1997 | Chemosphere1997，35，4： | 1 |
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