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| 1 | Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas显示文摘In this review we focus on lymphoepitheliomalike hepatocellular carcinomas(LEL-HCC) and lymphoepithelioma-like cholangiocarcinomas(LEL-ICC). Despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune systemand neoplastic cells. Approximately half of LELHCC arise in the context of chronic hepatitis C virus(HCV) infection and have been described both in Eastern and Western patients. By contrast, LEL-ICC is associated in almost all cases with Epstein-Barr virus(EBV) infection and exhibits the same epidemiological features of EBV related malignancies. Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both LEL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival. How this behavior is related to distinct genetic alterations and tumor microenvironment is unclear. The pathophysiological mechanisms of lymphoid infiltrations seem to be different among the two groups of tumors. In fact, LEL-HCC frequently arises in the context of inflammatory changes driven by HCV infection, and has been recognized as a variant of classical hepatocellular carcinoma. At variance, lymphocyte recruitment of LEL-ICC is similar to that described in nasopharyngeal carcinoma and gastric LEL, and possibly depends on the expression pattern of latent EBV infection. | Antonio Solinas Diego F Calvisi | 2015 | World Journal of Gastroenterology2015，21，12： | 9 |
| 2 | The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages显示文摘 | Paola Allavena Antonio Sica Graziella Solinas Chiara Porta Alberto Mantovani | 2007 | Critical Reviews in Oncology and Hematology2007，，1： | 5 |
| 3 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 4 | Laparoscopic and open gastric resections for malignant lesions: A prospective comparative study显示文摘 | J.–L. Dulucq P. Wintringer C. Stabilini L. Solinas J. Perissat A. Mahajna | 2005 | Surgical Endoscopy2005，，7： | 2 |
| 5 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 6 | Mode of action and application of scorpion primers to mutation detection显示文摘 | THELWELL N MILLINGTON S SOLINAS A | 2000 | Nucleic Acids Res2000，28，： | 1 |
| 7 | Efficient arithmetic on Koblitz curves显示文摘 | Solinas J A | 2000 | Designs Codes and Cryptography2000，19，23： | 1 |
| 8 | Efficient arithmetic on Koblitz eurves 显示文摘 | Solinas J A | 2000 | Designs codes and Cryptography2000，19，19： | 1 |
| 9 | Tumor-associat- ed macrophages (TAM) as major players of the cancer-related inflammation显示文摘 | Solinas G Germano G Mantovani A | 2009 | J Leukoc Biol2009，86，5： | 1 |
| 10 | Efficient Arithmetic on Koblitz Curves显示文摘 | Solinas J A | 2000 | Designs Codes and Cryptography2000，19，23： | 1 |
| 11 | Part-level object recognition using superquadrics 显示文摘 | Jaka Krivic France Solina | 2004 | Computer Vision and Image Understanding (S1077-3142)2004，95，： | 1 |
| 12 | Determination of the anisotropy constant and saturation magnetization and magneticproperties of powders of an iron - platinum alloy 显示文摘 | Ivanov 0 A Solina L V Demshina V A | 1973 | Physics of Metals and Metallography1973，35，1： | 1 |
| 13 | Laparoscopic and open gastric resections for malignant lesions: A prospective comparative study显示文摘 | J.–L. Dulucq P. Wintringer C. Stabilini L. Solinas J. Perissat A. Mahajna | 2005 | Surgical Endoscopy2005，，7： | 1 |
| 14 | Effects of potassium addition on the acidity and reducibility of chromia/alumina dehydrogenation catalysts 显示文摘 | Rombi E Cutrufello M G Solinas V | 2003 | Ap- plied Catalysis A:General2003，251，： | 1 |
| 15 | The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages显示文摘 | Allavena P Sica A Solinas G | 2008 | Crit Rev Oneol Hematol2008，66，1： | 1 |
| 16 | The endocannabinoid system in brain reward processes显示文摘 | Solinas M Goldberq SR Piomelli D | 2008 | Br J Pharmacol2008，154，2： | 1 |
| 17 | 显示文摘 | | 2003 | JMol Catal A2003，20，4205： | 1 |
| 18 | Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance 显示文摘 | TUNCMAN G HIROSUMI J SOLINAS G | 2006 | Proc Natl Acad Sci USA2006，103，10： | 1 |
| 19 | Nanotribology of a Kr monolayer:a quartz crystal mierobalance study of atomicscale friction 显示文摘 | Krim J Solina D H Chiarello R | 1991 | Physical Review Letter1991，66，2： | 1 |
| 20 | Duplex scorpion primers in SNP analysis and FRET applications显示文摘 | Solinas A Brown L J McKeen C | 2001 | Nucl Acids Res2001，29，20： | 1 |
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