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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 3 | 局部供磷对玉米根系生长、磷吸收速率的影响显示文摘玉米幼苗种子根局部供磷可明显改变根系的形态。供磷区侧根生长增加,无磷区侧极生长减少。供磷区1次、2次侧根长度与2次侧根数量明显增加;而1次侧根数量则不增加。供磷区缩小时,根系生长加快,单位根区磷吸收速率增加,但单位根重磷吸收速率的增加不很明显。磷局部供应植株主要通过供磷区根系的生长来增加磷的吸收,以满足植株对磷的需求。局部供磷植株中转运到供磷根区的光合产物明显多于无磷根区。 | 朱祝军 孙羲 Sattelmacher B Thoms K | 1993 | 植物生理学报(0257-4829)1993，19，3： | 6 |
| 4 | Assessing adequacy of emergency provider documentation among interhospital transferred patients with acute aortic dissection显示文摘BACKGROUND: Acute aortic dissection(AoD) is a hypertensive emergency often requiring the transfer of patients to higher care hospitals; thus, clinical care documentation and compliance with the Emergency Medical Treatment and Active Labor Act(EMTALA) is crucial. The study assessed emergency providers(EP) documentation of clinical care and EMTALA compliance among interhospital transferred AoD patients.METHODS: This retrospective study examined adult patients transferred directly from a referring emergency department(ED) to a quaternary academic center between January 1, 2011 and September 30, 2015. The primary outcome was the percentage of records with adequate documentation of clinical care(ADoCC). The secondary outcome was the percentage of records with adequate documentation of EMTALA compliance(ADoEMTALA). RESULTS: There were 563 electronically identified patients with 287 included in the final analysis. One hundred and five(36.6%) patients had ADoCC while 166(57.8%) patients had ADoEMTALA. Patients with inadequate documentation of EMTALA(IDoEMTALA) were associated with a higher likelihood of not meeting the American Heart Association(AHA) ED Departure SBP guideline(OR 1.8, 95% CI 1.03–3.2, P=0.04). Male gender, handwritten type of documentation, and transport by air were associated with an increased risk of inadequate documentation of clinical care(IDoCC), while receiving continuous infusion was associated with higher risk of IDoEMTALA.CONCLUSION: Documentation of clinical care and EMTALA compliance by Emergency Providers is poor. Inadequate EMTALA documentation was associated with a higher likelihood of patients not meeting the AHA ED Departure SBP guideline. Therefore, Emergency Providers should thoroughly document clinical care and EMTALA compliance among this critically ill group before transfer. | Mark Rose Carina Newton Benchaa Boualam Nancy Bogne Adam Ketchum Umang Shah Jordan Mitchell Safura Tanveer Tucker Lurie Walesia Robinson Rebecca Duncan Stephen Thom Quincy Khoi Tran | 2019 | World Journal of Emergency Medicine2019，10，2： | 5 |
| 5 | 非传统的纺织品后整理 第一部分:以一氯三嗪-β-环糊精为粘合剂的多种功能整理显示文摘描述了以一氯三嗪-β-环糊精为粘合剂的多种功能整理的特性和应用。环糊精(CD)耐久纺织品后整理在纺织后整理中具有重要的地位,尤其是在异味控制与弱化、增加穿着舒适性及医用纺织品领域。最新的技术利用反应性一氯三嗪-β-环糊精(MCT-β-CD)作为交联剂和三官能团结合剂能够增加环糊精整理的粘合与配位,同时,使得开发多种生物活性高分子(化合物)耐久整理成为可能。 | D. Knittel G. Thoms H.-J. Buschmann E. Schollmeyer 钟毅(译) 陈水林(校) | 2007 | 国际纺织导报2007，35，3： | 4 |
| 6 | 案例教学法——一种很有效的环境教育方式显示文摘在教师进行有关环境知识的教学时,经常将学生作为听众,把知识记忆当成是目标,但这样做,很可能丧失了更富有教育意义的“思维过程”,这一过程的意义在于:教师可以有效地培养学生分析问题的方法、技能和态度,而这些宝贵的东西也正是通过学生自己的参与实现的。下面介绍的案例教学法无疑为大家开启了一扇能有效促进学生学习角色转变和参与方法训练的新窗口。 | Thom J.McEvoy | 2001 | 环境教育2001，，4： | 4 |
| 7 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 8 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 9 | 华盛顿湾鲑鱼(Oncorhynchus spp.)生境恢复方案探讨显示文摘基于华盛顿湾生境恢复工程项目,分析了人类历史行为对华盛顿湾造成的景观格局演变,介绍了华盛顿湾作为鲑鱼(Oncorhynchus spp.)栖息地的生境受损问题。围堤、铺设堤道等历史活动造成了华盛顿湾内的生境破碎化及湾内潮汐水文和动力沉积过程的改变,并且影响了湾内植物和鱼类的分布。堤道和涵洞有限的水通量所造成的湾内水文连通度和能量输入的下降,是导致华盛顿湾内生境受损的关键原因。对为了恢复湾内水文传输过程而提出的拆堤变桥的生境恢复方案,进行了比较、讨论和经验总结。讨论了该生境恢复方案对长江河口地区鱼类资源保护、尤其是对幼鱼栖息地恢复工作的借鉴作用;提出应注意从系统生态学的角度出发,充分结合历史调查数据,对华盛顿湾生境状况进行评估,以掌握其生境受损关键原因,借助生态系统自我平衡能力,实现生态系统功能的恢复;就完善鱼类栖息地功能的完整性和连续性提出了建议。 | 孟海星 陆健健 Ronald Thom | 2014 | 湿地科学2014，12，2： | 3 |
| 10 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 11 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 12 | 2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Peripheral Artery Disease (Updating the 2005 Guideline)显示文摘 | Thom W. Rooke Alan T. Hirsch Sanjay Misra Anton N. Sidawy Joshua A. Beckman Laura K. Findeiss Jafar Golzarian Heather L. Gornik Jonathan L. Halperin Michael R. Jaff Gregory L. Moneta Jeffrey W. Olin James C. Stanley Christopher J. White John V. White R. E | 2011 | Journal of the American College of Cardiology2011，，： | 2 |
| 13 | Seasonal degree-day statistics for the Unite States显示文摘 | THOM H C S | 1952 | Mon Wea Rew1952，80，9： | 1 |
| 14 | Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:Principal results of the conduit Function Evaluation stndy显示文摘 | CAFé:Willam SB Lacy PS Thom SM | 2006 | Circulation2006，113，： | 1 |
| 15 | Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:principal results of the Conduit Artery Function evaluation (CAFE) Study显示文摘 | Willinams B Lacv PS Thom SM | 2006 | Circulation2006，113，9： | 1 |
| 16 | Risks of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery显示文摘 | Landon MB Spong CY Thom E | 2006 | Am J Obstet Gynecol2006，108，： | 1 |
| 17 | An ecosystem approach for determining environmental water allocations in Australian dryland river systems: the role of geomorphology显示文摘 | Thoms M C Sheldon F | 2002 | Geomorphology2002，47，： | 1 |
| 18 | A multicenter, ran- domized trial of treatment for mild gestational diabetes 显示文摘 | Landon MB Spong CY Thom E | 2009 | N Engl J Med2009，361，14： | 1 |
| 19 | Probingaprotein-protein interaction by in vitro evolution显示文摘 | THOM G COCKROFT A C BUCHANAN A G | 2006 | Proc Natl Acad SciUSA2006，103，20： | 1 |
| 20 | Characterization of polysac- charide structure and interactions by circular dichroism: Order - disorder transition in the calcium alginate system 显示文摘 | Morris E R Rees D A Thom D | 1973 | Journal of the Chemical Society - Chemical Communication1973，7，： | 1 |
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