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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 3 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 4 | Characterization of polysac- charide structure and interactions by circular dichroism: Order - disorder transition in the calcium alginate system 显示文摘 | Morris E R Rees D A Thom D | 1973 | Journal of the Chemical Society - Chemical Communication1973，7，： | 1 |
| 5 | A study of resist flow during nanoimprint lithography显示文摘 | MACINTYRE D S THOMS S | 2005 | Microelectronic Engineering2005，7879，： | 1 |
| 6 | Role of nitric oxide - derived oxidants in vascular injury from carbon monoxide in the rat 显示文摘 | Fisher D Xu Ya | 1999 | Am J Physiol1999，276，3： | 1 |
| 7 | Delayed neuropathology after carbon monoxide poisoning is immune-mediated显示文摘 | Thom SR Bhopale VM Fisher D | 2004 | Proc Nat Acad Sci USA2004，101，13： | 1 |
| 8 | Fabrication of 3 nm wires using 100 keV electron beam lithography and poly(methyl methacrylate)resit显示文摘 | Thoms S Beaumont S P | 1996 | Appl Phys Lett1996，68，： | 1 |
| 9 | Delayed neuropathology after carbon monoxide poisoning is immune-mediated显示文摘 | THOM S R BHOPALE V M FISHER D | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 10 | Delayed neuropathology after carbon monoxide poisoning is immunemediated显示文摘 | Thom SR Bhopale VM Fisher D | 2004 | Proc Natl Acad Sci USA2004，101，13： | 1 |
| 11 | Chronic renal disease, inflammation and atherosclerosis: new concepts about an old problem 显示文摘 | Dummer C D Thomé F S Veronese F V | 2007 | Rev Assoc Med Bras2007，53，5： | 1 |
| 12 | Delayed neuropathology after carbon monoxide poisoning is immune-mediated显示文摘 | Thom SR Bhopale VM Fisher D | 2004 | PNAS2004，101，13： | 1 |
| 13 | Diagnosis,management and treatments of hepatitis C显示文摘 | Strade D B Wright T Thom D C | 2004 | Hepatology2004，39，： | 1 |
| 14 | Delayed neuropathology after carbon monoxide poisoning is immune-mediated显示文摘 | Thom S R Bhopale V M Fisher D | | 0，，： | 1 |
| 15 | Prevalence,serotype diversity, and antimicrobial resistance of Salmonellain imported shipments of spice offered for entry to theUnited States, FY2007-FY2009 显示文摘 | JANE MV D DARIA K THOM AS S H | 2013 | Food Microbiology2013，34，： | 1 |
| 16 | A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy 显示文摘 | Rouse D J Hirtz DG Thom E | 2008 | N Engl J Med2008，359，9： | 1 |
| 17 | The riverine eco- system synthesis: Biocomplexity in river networks across space and time 显示文摘 | Thorp J H Thoms M C and Delong M D | 2006 | River research and application2006，，22： | 1 |
| 18 | Release of vancomycin andteicoplanin from a plasticized and resorbable gelatin sponge: invitro investigation of a new antibiotic delivery system with glycopeptides 显示文摘 | Drognitz O Thom D KrUger T | 2006 | Infection2006，1，： | 1 |
| 19 | Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat显示文摘 | Fisher D Xu Ya | 1999 | Am J Physiocal1999，276，3： | 1 |
| 20 | Genetic variation in IL28B predicts hepatitis C treatm ent-induced viralclearance显示文摘 | Ge D Fellay J Thom pson AJ | 2009 | Nature2009，461，7262： | 1 |
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