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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 3 | Cirrhotic ascites review: Pathophysiology, diagnosis and management显示文摘Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities. | Christopher M Moore David H Van Thiel | 2013 | World Journal of Hepatology2013，5，5： | 13 |
| 4 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 5 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 6 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 7 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 8 | 采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果显示文摘目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ISH与RDN反应的可能交互作用。 | Fengler K Rommel KP Lapusca R Blazek S Besler C Hartung P von Roeder M Kresoja KP Desch S Thiele H Lurz P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，7： | 2 |
| 9 | 无创筛查酒精相关性肝纤维化的成本效果分析显示文摘【据《Hepatology》2019年10月报道】题:无创筛查酒精相关性肝纤维化的成本效果分析(作者Asphaug L等)酒精相关性肝病常常难以被发现,直到终末期出现肝功能失代偿表现时才被引起注意。该研究旨在分析针对进展期酒精相关性肝纤维化的经济、高效的无创筛查方法的成本效果。来自挪威的Asphaug等进行了一项现实世界数据的研究,作者从丹麦多中心招募了具有肝活检病理结果的大量饮酒者,评价一级诊疗中心采用的4种筛查策略:(1)传统的肝功能化验,如果结果阳性则进一步完善腹部超声;(2)肝纤维化血清学标志物:强化的肝纤维化(ELF)试验,如果结果阳性则进一步完善肝硬度(LSM)检查;(3)三级策略:在进行第2种策略前进行Forns索引(根据年龄、血小板计数、GGT、胆固醇水平得到的无创预测公式);(4)直接进行LSM检查。应用决策树和Markov联合模型进一步评价短期结果(每项准确诊断的成本)和长期结果[质量调整生命年(QALYs)]。 | 周胜云 段志辉 ASPHAUG L THIELE M KRAG A | 2020 | 临床肝胆病杂志2020，36，1： | 2 |
| 10 | A vital sugar code for ricin toxicity显示文摘 | Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger | 2017 | Cell Research2017，27，11： | 2 |
| 11 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 12 | Assays for the functional activity of the mannan-binding lectin pathway of complement activation显示文摘 | M? ller-Kristensen M Jensen L | 2002 | Immunobiology2002，205，45： | 1 |
| 13 | Charging processes in low vacuum scanning electron microscopy显示文摘 | THIEL B L TOTH M GRAVEN J P | 2004 | Microscopy and Microanalysis2004，，10： | 1 |
| 14 | Evidence for the presence of two novel pestivirus species 显示文摘 | Avalos-Ramirez R Orlich M Thiel H J | 2001 | Virology2001，286，： | 1 |
| 15 | Influence of observational noise on the recurrence quantification analysis显示文摘 | THIEL M ROMANO M C KURTHS J | 2002 | Physica D-Nonlinear Phenomena2002，171，： | 1 |
| 16 | Simulating flow in heterogeneous systems using streamtubes and streamlines显示文摘 | Thiele M R Batycky R P Blunt M J | 1996 | SPERE1996，10，1： | 1 |
| 17 | Imaging of posterior cham- ber phakic intraocular lens by optical coherence tomography 显示文摘 | Beelunann M Ullrich S Thiel M J | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 18 | Statistical analysis of the effect of magnet placement on cogging torque in fractional pitch permanent magnet motors 显示文摘 | HEINS G BROWN T THIELE M | 2011 | IEEE Transactions on Magnetics2011，47，8： | 1 |
| 19 | Recurrence plots for the analysis of complex systems显示文摘 | Norbert Marwan M Carmen Romano Marco Thiel | 2007 | Physics Reports2007，438，5： | 1 |
| 20 | Thermodynamic equipartition for increased second law efficiency显示文摘 | THIEL G P MCGOVERN P K ZUBAIR S M | 2014 | Applied Energy2014，136，4： | 1 |
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