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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | 以食物为基础的膳食模式与慢性疾病预防显示文摘Matthias B Schulze及其同事讨论了目前已知的膳食模式与癌症、冠心病、卒中及2型糖尿病的关联,重点在仍不确定的领域和未来的研究方向。 | Matthias B Schulze Miguel A Martínez-González Teresa T Fung Alice H Lichtenstein Nita G Forouhi 陈夏燕(译) 王燕芳(译) 武阳丰(校) | 2021 | 英国医学杂志中文版2021，24，3： | 3 |
| 4 | Racial differences in effectiveness of α-fetoprotein for diagnosis of hepatocellular carcinoma in hepatitis C virus cirrhosis显示文摘 | Mindie H Nguyen Ruel T Garcia Peter W Simpson Teresa L Wright Emmet B Keeffe | 2002 | Hepatology2002，，2： | 2 |
| 5 | Leader behaviors and the work environment for creativity: Perceived leader support显示文摘 | Teresa M Amabile Elizabeth A Schatzel Giovanni B Moneta Steven J Kramer | 2004 | The Leadership Quarterly2004，，1： | 2 |
| 6 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 7 | A new five-parameter MOS transistor mismatch model显示文摘 | Teresa S G Bernabe L B | 2000 | IEEE Electron Device Letter2000，21，1： | 1 |
| 8 | Selenium:an essential element for immune function显示文摘 | Roderick C M Teresa S R Geoffrey J B | 1998 | Immunology today1998，19，8： | 1 |
| 9 | Amino acid composition of the milk of some mammalian species changes with stage of lactation 显示文摘 | Teresa A D Hanh V N Roselina G B | 1994 | British Journal of Nutrition1994，72，： | 1 |
| 10 | Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 显示文摘 | TERESA T F ERIC B R DONNA S | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 11 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 12 | Intimate relations-fact or fiction:An analysis of business to business relationships in IRISH companies显示文摘 | SEAN B TERESA B BRIAN F | 2001 | Irish Journal of Management2001，22，1： | 1 |
| 13 | Preparation, characterization and reactivity of V-and/or co-containing AlPO- 18 materials (VCoAPO-18) in the oxidative dehydrogenation of ethane 显示文摘 | PATRICIA C TERESA B JOSE M L N | 2004 | Micropor Mesopor Mater2004，67，23： | 1 |
| 14 | Calcineurin is essential for virulence in Candida albicans显示文摘 | Teresa B Barbara B Klaus S | 2003 | Infect Immu2003，71，9： | 1 |
| 15 | H2S Adsorption/oxidation on adsorbents obtained from pyrolysis of sewage-sludge-derived fertilizer using zinc chloride activation 显示文摘 | Andrey B David C L Teresa J B | 2001 | Ind Eng Chem Res2001，40，16： | 1 |
| 16 | Recent developments in ocular gene therapy显示文摘 | Teresa B | 2003 | Exp Eye Res2003，76，： | 1 |
| 17 | Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice显示文摘 | Mattia M Silvia B Teresa R | 2011 | Neurotherapeutics2011，8，2： | 1 |
| 18 | Influence of coal oxidation upon char gasification reactivity显示文摘 | Teresaálvarez Fuertes A B Pis J J | 1995 | Fuel1995，74，5： | 1 |
| 19 | What is personalized medicine: sharpening a vague term based on a systematic literature review显示文摘 | Sebastian S Corinna K Teresa B | 2013 | BMC Medical Ethics2013，14，1： | 1 |
| 20 | Effect of pore structure and surface chemistry of virgin activated carbons on removal of hydrogen sulfide显示文摘 | Teresa J B | 1999 | Carbon1999，37，： | 1 |
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