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| 1 | 贵州省2003~2004年麻疹疫苗强化免疫效果评价显示文摘目的总结贵州省实施麻疹疫苗(MV)强化免疫的效果。方法综合分析强化免疫期间的现场调查、项目年度评估报告和强化免疫后1年的麻疹监测系统和法定传染病报告系统的疫情资料。结果本次强化免疫共计接种目标儿童8611528人,报告接种率和调查接种率均〉95%;共报告预防接种异常反应354例,发生率4.11/10万;接种后经过1个最长潜伏期,麻疹发病数明显减少,每周报告疑似麻疹2~34例,且近1/3为风疹;目前78.3%的麻疹病例发生在8月龄~14岁,病例71.1%无免疫史或免疫史不详。结论高质量MV强化免疫能够迅速降低麻疹发病,实施该项工作的关键环节包括广泛的社会动员、细致的培训和清晰的物流是前提保障;目标人群的确定必须结合当地流行病学监测的资料;尽可能在较大范围内开展,以形成有效的人群免疫屏障阻断麻疹病毒传播;接种时间选择在麻疹低发季节,且尽可能在15d内完成;保证〉95%接种率是活动的前提目标;必须针对可能发生的预防接种后异常反应做好充分准备;如果该地区常规免疫服务质量在1~2年内不能明显加强,需要同时考虑4~5年后的后续免疫。 | 左树岩 梁晓峰 殷大鹏 尤雪丹 郭飚 童亦兵 朱青 张大勇 杜雯 Lisa lee Yoshihiro Takashima 于竞进 | 2006 | 中国计划免疫2006，12，1： | 67 |
| 2 | 健康教育对提高农牧区新生儿乙型肝炎疫苗首针及时接种率的效果分析显示文摘目的探讨在农牧区开展健康教育推动新生儿乙型肝炎(乙肝)疫苗首针(HepB1)及时接种。方法开发宣传品、培训专业人员、动员当地知名人士开展宣传和健康教育活动。结果居民知晓率、新生儿HepB1及时接种率分别由项目前的48.84%、42.61%上升到项目后的91.27%、75.02%,差异均有非常显著的统计学意义(χ2=57.13,χ2=838.16;P均<0.001)。结论在农牧区开展乙肝预防控制健康教育,可促进新生儿HepB1及时接种率的提高。 | 李秀芹 万玛加 李青旗 李承宁 胡苑笙 张永基 乔华 王建仁 马耀军 崔富强 梁晓峰 倪大新 Yoshihiro Takashima | 2007 | 中国计划免疫2007，13，1： | 16 |
| 3 | Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis显示文摘AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis.METHODS: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/ HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%,respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION: The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis. | Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi | 2012 | World Journal of Hepatology2012，4，1： | 10 |
| 4 | 青海省2006年麻疹减毒活疫苗强化免疫效果评价显示文摘目的总结青海省2006年麻疹减毒活疫苗(MV)强化免疫效果,探讨消除麻疹策略。方法综合分析MV强化免疫现场调查资料、评估报告和法定传染病报告系统资料。结果青海省2006年MV强化免疫共接种目标儿童1 100 315人,报告接种率和调查接种率均>95%;强化免疫后麻疹发病锐减;漏卡儿童和零剂次免疫儿童主要分布在个别地区8~11月龄婴儿中。结论青海省2006年MV强化免疫后麻疹发病显著降低;但某些地区常规免疫服务质量如不能明显加强,需考虑4~5年后开展MV后续免疫。 | 张永基 张守荣 胡苑笙 阿克忠 赵建海 余文周 左树岩 Yoshihiro Takashima 石西安 | 2007 | 中国计划免疫2007，13，3： | 10 |
| 5 | Near-infrared photoimmunotherapy of pancreatic cancer using an indocyanine green-labeled anti-tissue factor antibody显示文摘AIM To investigate near-infrared photoimmunotherapeutic effect mediated by an anti-tissue factor(TF) antibody conjugated to indocyanine green(ICG) in a pancreatic cancer model.METHODS Near-infrared photoimmunotherapy(NIR-PIT) is a highly selective tumor treatment that utilizes an antibody-photosensitizer conjugate administration, followed by NIR light exposure. Anti-TF antibody 1849-ICG conjugate was synthesized by labeling of rat IgG2 b anti-TF monoclonal antibody 1849(anti-TF 1849) to a NIR photosensitizer,ICG. The expression levels of TF in two human pancreatic cancer cell lines were examined by western blotting. Specific binding of the 1849-ICG to TF-expressing BxPC-3 cells was examined by fluorescence microscopy. NIR-PITinduced cell death was determined by cell viability imaging assay. In vivo longitudinal fluorescence imaging was used to explore the accumulation of 1849-ICG conjugate in xenograft tumors. To examine the effect of NIRPIT, tumor-bearing mice were separated into 5 groups:(1) 100 μg of 1849-ICG i.v. administration followed by NIR light exposure(50 J/cm2) on two consecutive days(Days 1 and 2);(2) NIR light exposure(50 J/cm2) only on two consecutive days(Days 1 and 2);(3) 100 μg of 1849-ICG i.v. administration;(4) 100 μg of unlabeled antiTF 1849 i.v. administration; and(5) the untreated control. Semiweekly tumor volume measurements, accompanied with histological and immunohistochemical(IHC) analyses of tumors, were performed 3 d after the 2nd irradiation with NIR light to monitor the effect of treatments. RESULTS High TF expression in BxPC-3 cells was observed via western blot analysis, concordant with the observed preferential binding with intracellular localization of 1849-ICG via fluorescence microscopy. NIR-PIT-induced cell death was observed by performing cell viability imaging assay. In contrast to the other test groups, tumor growth was significantly inhibited by NIR-PIT with a statistically significant difference in relative tumor volumes for 27 d after the treatment start date [2.83 ± 0.38(NIR-PIT) vs 5.42 ± 1.61(Untreated), vs 4.90 ± 0.87(NIR), vs 4.28 ±1.87(1849-ICG), vs 4.35 ± 1.42(anti-TF 1849), at Day 27, P < 0.05]. Tumors that received NIR-PIT showed evidence of necrotic cell death-associated features upon hematoxylin-eosin staining accompanied by a decrease in Ki-67-positive cells(a cell proliferation marker) by IHC examination.CONCLUSION The TF-targeted NIR-PIT with the 1849-ICG conjugate can potentially open a new platform for treatment of TF-expressing pancreatic cancer. | Winn Aung Atsushi B Tsuji Aya Sugyo Hiroki Takashima Masahiro Yasunaga Yasuhiro Matsumura Tatsuya Higashi | 2018 | World Journal of Gastroenterology2018，24，48： | 7 |
| 6 | 黄南藏族自治州2004年新生儿乙型肝炎疫苗首针及时接种率及影响因素调查显示文摘目的了解影响黄南藏族自治州新生儿乙型肝炎(乙肝)疫苗首针(HepB1)及时接种的因素,探索提高农牧区新生儿HepB1及时接种率的方法。方法通过查阅文献、现场访问、入户调查、问卷调查等方式收集有关资料及信息。结果2004年黄南藏族自治州新生儿HepB1报告及时接种率为42.61%,其中在医院出生新生儿HepB1及时接种率为91.77%,在家出生新生儿HepB1及时接种率为19.58%;全州住院分娩率为31.90%;入户接种占51.06%;HepB1未及时接种原因主要是家长不知道,占39.66%。结论2004年全州新生儿HepB1及时接种率较低。今后要加大宣传和开展健康教育活动,掌握在家分娩孕妇的分娩信息和合理安排在家出生新生儿及时接种,是提高新生儿HepB1及时接种率的有效手段之一。 | 李承宁 万玛加 李秀芹 张永基 张昕伟 巴文生 李青旗 乔华 胡苑笙 马耀军 崔富强 梁晓峰 Yoshihiro Takashima 倪大新 | 2007 | 中国计划免疫2007，13，1： | 6 |
| 7 | 黄南藏族自治州提高新生儿乙型肝炎疫苗首针及时接种率策略研究显示文摘目的调查影响边远贫困农牧区新生儿乙型肝炎(乙肝)疫苗首针(HepB1)及时接种的主要因素,探索提高新生儿HepB1及时接种率的有效手段和模式。方法在黄南藏族自治州开展基线调查,制定针对性策略并实施。包括开展多途径、多渠道的健康教育及宣传活动;加强对医院相关人员的培训,确保在医院出生新生儿得到及时接种;加强疾病预防控制机构与妇幼保健机构、村医与接生员之间的沟通与合作,做好孕妇产前登记和随访工作,确保在家出生新生儿得到及时接种;加强督导和技术支持,定期监测、分析相关指标,不断完善相关策略。结果项目实施前、后全州HepB1及时接种率由2004年的42.61%上升到2005年的75.02%。结论通过项目的实施,显著提高了农牧区新生儿HepB1及时接种率。 | 张永基 胡苑笙 张昕伟 石西安 万玛加 李青旗 李承宁 李秀芹 崔富强 梁晓峰 倪大新 Yoshihiro Takashima | 2007 | 中国计划免疫2007，13，1： | 6 |
| 8 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 3 |
| 9 | Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse显示文摘AIM: To assess the risk of relapse in ulcerative colitis(UC) patients in clinical remission using mucosal status and fecal immunochemical test(FIT) results. METHODS: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores(MESs) and FIT results.RESULTS: Patients with an MES of 0(n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3(n = 100, 52%)(HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result(fecal hemoglobin concentrations ≤ 100 ng/m L) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score(HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse(HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing(MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk. | Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada Hiroyuki Okada | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 10 | 贝伐珠单抗联合S-1与伊立替康或mFOLF⁃OX6/CapeOX作为转移性结直肠癌一线治疗研究(TRICOLORE):一项随机、开放标签、Ⅲ期、非劣效性研究显示文摘目的:TRICOLORE研究既往报道的结果显示作为转移性结直肠癌一线治疗模式,S-1与伊立替康联合贝伐珠单抗的无疾病进展时间(PFS)非劣效于mFOLFOX6/CapeOX联合贝伐珠单抗,但首次报道时总生存期(OS)数据尚未完善。 | 邱萌 DENDA T TAKASHIMA A GAMOH M | 2021 | 结直肠肛门外科2021，27，5： | 3 |
| 11 | 《2021-2030年全球疫苗行动策略框架》给中国的启示显示文摘为更好地接种疫苗,使世界更健康、更安全和更繁荣,世界卫生组织拟定了《2021-2030年全球疫苗行动策略框架》,提出以接种对象为中心、突出国家领导力、合作伙伴助力、科学评价进展效果的四项核心工作原则和七项重点策略。中国需要制订国家未来十年疫苗接种行动计划,助力2019-2030年健康中国行动:以服务对象为中心,规划国家免疫规划长期目标和重点策略;加强系统合作、及早整合资源,提高疫苗接种率,最终控制和消除疾病;建立质量管理系统和风险管理系统,使“为每个接种对象接种安全、有效、优质和可负担的疫苗”成为初级卫生保健重要的一部分,助力人人享有健康和可持续发展目标。 | 左树岩 卢莉 Yoshihiro Takashima | 2020 | 首都公共卫生2020，14，2： | 2 |
| 12 | 定西市2005年出生儿童乙型肝炎疫苗首针及时接种率及影响因素调查显示文摘[目的]寻找影响定西市新生儿乙型肝炎(乙肝)疫苗首针(HepB1)及时接种的因素,探索提高贫困山区新生儿HepB1及时接种率的方法。[方法]通过查阅资料、入户调查、问卷调查等方式收集相关资料。[结果]共调查2005年出生新生儿840名,住院分娩率48.93%,HepB1及时接种率61.31%,其中住院分娩新生儿HepB1及时接种率88.56%,在家分娩新生儿HepB1及时接种率35.20%。未住院分娩的原因主要是住院费用太高、离医院太远和认为住院分娩没有必要(占87.18%)。村级接种工作仍以入户接种(占82.16%)为主,从所在村到乡镇卫生院领取疫苗和入户接种主要通过步行(分别占43.11%和68.58%)完成。[结论]定西市2005年新生儿HepB1及时接种率处于较低水平。主要影响因素是经济文化落后、新生儿住院分娩率较低、免疫规划宣传不够、对辖区内的孕产妇和新生儿摸底不清等。今后要通过加大宣传教育力度、开展孕产妇和新生儿入户调查摸底、加强与妇幼机构和妇检机构的合作等措施,进一步提高新生儿HepB1及时接种率。 | 漆可发 李慧 高丽 张晓曙 崔富强 Yoshihiro Takashima 倪大新 彭博识 | 2010 | 卫生软科学2010，24，2： | 2 |
| 13 | Focal fatty change of the liver adjacent to the falciform ligament: CT and sonographic findings in five surgically confirmed cases显示文摘 | Yoshikawa J Matsui O Takashima T | 1987 | AJR Am J Roentgenol1987，149，3： | 2 |
| 14 | Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor显示文摘 | Shay Soker Seiji Takashima Hua Quan Miao Gera Neufeld Michael Klagsbrun | 1998 | Cell1998，，： | 2 |
| 15 | Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction: Possible Contribution of Endoplasmic Reticulum Stress to Cardiac Myocyte Apoptosis显示文摘 | Ken-ichiro Okada Tetsuo Minamino Yoshitane Tsukamoto Yulin Liao Osamu Tsukamoto Seiji Takashima Akio Hirata Masashi Fujita Yoko Nagamachi Takeshi Nakatani Chikao Yutani Kentaro Ozawa Satoshi Ogawa Hitonobu Tomoike Masatsugu Hori Masafumi Kitakaze | 2004 | Circulation2004，，6： | 2 |
| 16 | Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection显示文摘 | Takaaki Koma Kumiko Yoshimatsu Midori Taruishi Daisuke Miyashita Rika Endo Kenta Shimizu Shumpei P. Yasuda Takako Amada Takahiro Seto Ryo Murata Haruka Yoshida Hiroaki Kariwa Ikuo Takashima Jiro Arikawa | 2012 | Journal of Virological Methods2012，，1： | 2 |
| 17 | 牛磺酸的神经变性机制与阿尔茨海默症治疗(英文)显示文摘1.Introduction In Alzheimer’s disease(AD),β-amyloid deposition and neurofibrilla y tangles(NFTs),composed of hyperphosphorylated tau fibrils are considered to be major pathologic features.Evidence from the genetic studies of familial AD has given rise to theβ-amyloid hypothesis in whichβ-amyloid is proposed as the cause of AD;thus,the reduction ofβ-amyloid has been | Akihiko Takashima | 2016 | Journal of Sport and Health Science2016，5，4： | 2 |
| 18 | Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau 显示文摘 | Takashima A Murayama M Murayama O | 1998 | Proc Natl Acad Sci USA1998，95，16： | 1 |
| 19 | Lamrl functional retroposen causes right ventricular dysplasia in mice 显示文摘 | Asano Y Takashima S Asakura M | 2004 | Nat Genet2004，36，2： | 1 |
| 20 | CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern显示文摘 | Takashima S Maruyama Y Hasegawa M | 2003 | AJR2003，180，3： | 1 |
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