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| 1 | Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy显示文摘Acute appendicitis(AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy(LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended resection in patients with an appendiceal mass. Nonoperative management of AA may be tolerated only in children. Postoperative complications increase according to the patient's factors, and temporal avoidance of emergent general anesthesia may be beneficial for high-risk patients. The surgeon's skill and cooperation of the hospital are important for successful LA. Delaying appendectomy for less than 24 h from diagnosis is safe. Additionally, a semi-elective manner(i.e., LA within 24 h after onset of symptoms) may be paradoxically acceptable, according to the factors of the patient, physician, and institution. Prompt LA is mandatory for AA. Fortunately, the Japanese government uses a universal health insurance system, which covers LA. | tomohide hori takafumi machimoto yoshio kadokawa toshiyuki hata tatsuo ito shigeru kato daiki yasukawa yuki aisu yusuke kimura maho sasaki yuichi takamatsu taku kitano shigeo hisamori tsunehiro yoshimura | 2017 | World Journal of Gastroenterology2017，23，32： | 18 |
| 2 | Impact of changing our cannulation method on the incidenceof post-endoscopic retrograde cholangiopancreatography pancreatitis after pancreatic guidewire placement显示文摘AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation method. METHODS: Between April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection (CI) using a single-lumen catheter (April 2001-May 2008) to wire-guided cannulation (WGC) using a double-lumen catheter (June 2008-October 2009). The CI protocol was also changed during the study period: in the first period it was used for routine pancreatography for detecting small pancreatic cancer (April 2001-November 2002), whereas in the second period it was not (December 2002-May 2008). In PGW with CI using a singlelumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were investigated.RESULTS: CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients (15.5%), and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% (10/27) in the patients who underwent CI with routine pancreatography, 14.3% (11/77) in those who underwent CI without routine pancreatography, and 2.6% (1/38) in those who underwent WGC. In all patients who underwent CI using a singlelumen catheter, the incidence of PEP was 20% (21/104), which was significantly higher than that in WGC using a double-lumen catheter. In univariate and multivariate analysis, CI using a single-lumen catheter showed a high, statistically significant, odds ratio for PEP after PGW. CONCLUSION: The practice of a cannulation method involving the use of a double-lumen catheter minimizes the CI dose administered to the pancreatic duct and reduces the incidence of PEP after PGW. | Takeshi Hisa Ryusuke Matsumoto Masato Takamatsu Masayuki Furutake | 2011 | World Journal of Gastroenterology2011，17，48： | 7 |
| 3 | Recent advances in photodynamic diagnosis of gastriccancer using 5-aminolevulinic acid显示文摘Photodynamic diagnosis based on 5-aminolevulinic acidinduced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative realtime fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma. | Noriaki Koizumi Yoshinori Harada Takeo Minamikawa Hideo Tanaka Eigo Otsuji Tetsuro Takamatsu | 2016 | World Journal of Gastroenterology2016，22，3： | 7 |
| 4 | Regulation of immune cell responses by semaphorins and their receptors显示文摘Semaphorins 原来作为涉及 neuronal 系统的开发的轴突指导因素被识别。然而,积累证据显示那 semaphorins 的几个成员,所谓的鈥榠m mune semaphorins 鈥吗?关键地涉及有免疫力的回答的各种各样的阶段。这些 semaphorins 在生理、病理学的有免疫力的回答期间调整两个有免疫力的房间相互作用和有免疫力的房间 trafficking。这里,我们在有免疫力的回答考察 semaphorins 和他们的受体的下列二个功能的方面:他们在在有免疫力的房间 trafficking 的房间鈥揷e ll 相互作用和他们的参与的功能。 | Hyota Takamatsu Tatsusada Okuno Atsushi Kumanogoh | 2010 | Cellular & Molecular Immunology2010，7，2： | 6 |
| 5 | Segmental gastrectomy with radical lymph node dissection for early gastric cancer显示文摘AIM: To describe a new surgical technique and evaluate the early results of segmental gastrectomy (SG) with modified D2 lymph node (LN) dissection for early gastric cancer (EGC). METHODS: Fourteen patients with EGC underwent SG with modified D2 dissection from 2006 to 2008. Their operative results and postoperative courses were compared with those of 17 patients who had distal gastrectomy (DG) for EGC during the same period. RESULTS: Operating time, blood loss, and hospital stay were similar between the 2 groups. Postoperative complications developed significantly more frequently in the DG group than in the SG group. Mean number of dissected LNs per each station in the SG group was comparable with that in the DG group. Postoperative recovery of body weight was significantly better in the SG group than in the DG group. The incidence of reflux esophagitis and gastritis after surgery was less frequent in the SG group than in the DG group.CONCLUSION: SG with modified D2 LN dissection may be a new function-preserving gastrectomy that is feasible for treatment of EGC with possible LN involvement. | Takeru Matsuda Kunihiko Kaneda Manabu Takamatsu Keishi Aishin Masahide Awazu Akiko Okamoto Katsunori Kawaguchi | 2010 | World Journal of Gastroenterology2010，16，41： | 6 |
| 6 | Development of ICPF Actuated Underwater Microrobots显示文摘发展是我们的目标在水下为医药、工业的应用程序的 microrobots。这种在水下 microrobots 应该有灵活性,好反应和安全的特征。它的结构应该简单,它能被低电压驾驶并且不生产污染或噪音。低激活电压和爱奥尼亚的进行的聚合物电影(ICPF ) 的快弯曲回答被认为为构造致动器和传感器的各种各样的类型很有用、吸引人。在这篇论文,我们将首先学习致动器使用了在的 ICPF 的特征在水下认识到游泳并且走的 microrobot。然后,我们建议作为伺服致动器利用仅仅一个 ICPF 的在水下的游泳 microrobot 的一个新原型模型。通过理论上的分析, microrobot 的运动机制被说明。它能向前并且垂直地游泳。在动人的速度和信号电压振幅和信号频率之间的关系在试验性的学习以后被获得。最后,我们在场一篇小说在水下的像螃蟹的走 microrobot 说出 crabliker-1。它有八条腿,并且每条腿由二 ICPF 组成。八足类动物步法的三个样品过程与一个新分析方法被建议。试验性的结果显示像螃蟹在水下 microrobot 能表现横向并且旋转运动螃蟹的腿什么时候协作。关键词在水下 microrobot -爱奥尼亚的进行聚合物电影( ICPF )致动器-运动机制-汝收到了的步法Xiu分她在自动化的学士度和在从哈尔滨造船工程的控制理论和申请的 M.Sc 度开创,哈尔滨,在 1987 和 1990 的中国,分别地并且在从设计大学的哈尔滨的控制理论和控制工程的博士学位,哈尔滨,在 2003 的中国。她当前是在 Biomimetic 微机器人和系统的实验室的一个教授,哈尔滨工程大学,中国。她出版了超过 40 份杂志和会议报纸。她的当前的研究兴趣包括 biomimetic microrobot 系统,网络计算,图象处理和模式识别。高宝凤在辽宁出生了,在 1981 的中国。他收到了 B.Sc。在来自东北福雷斯特大学的森林工程(国际工程工程管理) 的度,哈尔滨,在 2003 的中国。他当前从 Biomimetic 微机器人和系统的实验室在控制理论和控制工程正在追求他的 M.Sc 学位,自动化的学院,哈尔滨工程大学,哈尔滨,中国。他的研究兴趣包括微机器人学和自动化,特别象步法控制那样的微机器人学的控制在水下 microrobot。郭淑祥从光学和好力学的长春研究所在 mechanical engineering 收到了他的学士和硕士学位,长春,在 1983 和 1986 的中国,分别地并且在来自名古屋大学的 mechano 信息科学和系统的博士学位,名古屋,在 1995 的日本。在 1995,他是在 Mie 大学的一个教师成员, Mie,日本并且在 1998 在 Kagawa 大学, Kagawa,日本。当前,他是在在 Kagawa 大学的聪明的机械系统工程的部门的一个教授。他出版了大约 140 篇审阅杂志和会议论文。他的当前的研究兴趣包括微机器人学和 mechatronics,为最小的侵略外科的微机器人学系统,微导管系统,微泵,和聪明的材料(SMA, ICPF ) 基于致动器。收到的研究从机械工程师( JSME )的日本协会的 Tokai 节授于的郭教授, Tokai 科技基础,和最好糊 IS 国际会议的奖品,控制科技上的 2003 国际会议的最好的论文奖品和 IEEE ROBIO2004 的最好的会议论文奖品在 1997 , 1998 , 2000 , 2003 和 2004 ,分别地。 | Xiu-Fen Ye,Bao-Feng Gao Automation College, Harbin Engineering University, Harbin 150001, PRC Shu-Xiang Guo Automation College, Harbin Engineering University, Harbin 150001, PRC Faculty of Engineering, Kagawa University, Takamatsu 761-0396, Japan Li-Quan Wang College of Mechanical Electrical Engineering, Harbin Engineering University, Harbin 150001, PRC | 2006 | International Journal of Automation and computing2006，3，4： | 4 |
| 7 | Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan显示文摘 | Seiki Tashiro T. Imaizumi H. Ohkawa A. Okada T. Katoh Y. Kawaharada H. Shimada H. Takamatsu H. Miyake T. Todani | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，5： | 4 |
| 8 | A case of very large intrahepatic bile duct adenoma followed for 7 years显示文摘A 70-year-old man was referred to our hospital due to abnormal liver function. A tumor of 92 mm × 61 mm was detected on ultrasound screening of the left liver lobe. Although the tumor was suspected to be intrahepatic bile duct carcinoma, he had chronic heart disease and was unable to undergo surgery. Therefore, he was followed without further testing. No increase in tumor serum markers or tumor size was observed for the subsequent 7 years. We continued to suspect intrahepatic bile duct carcinoma, and we decided to perform a tumor biopsy. Tumor biopsy findings indicated intrahepatic bile duct adenoma(BDA), which is a rare benign epithelial liver tumor typically ranging from 1 mm to20 mm. We herein report a case of very large BDA followed for 7 years. | Futa Koga Hiroto Tanaka Seigo Takamatsu Shinnichi Baba Hiroshi Takihara Akioko Hasegawa Eri Yanagihara Taro Inoue Toshihiro Nakano Chie Ueda Wataru Ono | 2012 | World Journal of Clinical Oncology2012，3，4： | 3 |
| 9 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 10 | Four-week pegylated interferon a-2a monotherapy for chronic hepatitis C with genotype 2 and low viral load:A pilot,randomized study显示文摘AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33) with genotype 2 and low viral load(< 100 KIU/mL),who became HCV RNA negative after 1 wk of IFN treatment,were randomly allocated to receive a 4-or 12-wk treatment course at a ratio of 2:1,respectively,with a subsequent 24-wk follow-up period.Peg-IFN-a2a was administered subcutaneously at a dose of 180 μg or 90 μg once weekly.SVR was defined as absence of serum HCV RNA at the end of the follow-up period.RESULTS:All patients completed the treatment schedule,and more than half were symptom-free during the treatment.In the 4-wk treatment group,20 of 22(91%) patients achieved SVR.Two patients relapsed,but achieved SVR following re-treatment with peg-IFN-a2a alone.In the 12-wk treatment group,11 of 11(100%) patients attained SVR.CONCLUSION:Our results show that a 4-wk course of peg-IFN-a2a monotherapy can achieve a high SVR rate in 'IFN-sensitive' patients,without negatively affecting outcome. | Akihito Tsubota Ken-ichi Satoh Mashu Aizawa Seishi Takamatsu Yoshihisa Namiki Toshifumi Ohkusa Kiyotaka Fujise Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，47： | 3 |
| 11 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 12 | 不同摩尔质量聚碳酸酯的增韧改性显示文摘研究了弹性体SEBS(苯乙烯-乙烯/丁烯-苯乙烯共混物)和SEP(苯乙烯-乙烯/丙烯共混物)的加入对不同摩尔质量聚碳酸酯(PC)力学性能的影响。对于通用级PC及低摩尔质量的PC,其缺口冲击强度随样品厚度增加大幅度降低,而少量弹性体(SEPTON1003、SEPTON8006)的加入使其6.4mm厚样品缺口冲击强度有大幅度的提高,其它的力学性能如拉伸强度等变化不大。SEM和DSC分析表明:SEPTON与PC的相容性较好,共混物由PC明显的脆性断裂转变为韧性断裂。 | 张海涛 曹亚 陈金耀 何玉晖 Hideo Takamatsu Xiangsheng Zeng Noboru Higashida | 2005 | 塑料工业2005，33，11： | 2 |
| 13 | Growth process of small pancreatic carcinoma: A case report with imaging observation for 22 months显示文摘This report describes serial observations of the growth process of a small invasive ductal carcinoma (IDC) of the pancreas from imaging studies. Histopathological studies showed IDC with macroscopic retention cysts proximal to an intraductal papillary-mucinous adenoma with mild atypia of the branch duct type in the pancreatic body, with no relation between the two lesions. IDC was demonstrated as an extremely low-echoic mass resembling a cyst with an unclear margin on the initial endoscopic ultrasonography. We misinterpreted the low-echoic mass as a benign intraductal mucinous-papillary neoplasm (IPMN) based on findings of other imaging studies, and the patient was followed-up. The mass increased from 7 mm to 13 mm in diameter over 22 mo, and remained smaller than 10 mm in diameter for about 420 d. The tumor volume doubling time was 252 d. The Ki67 labeling index was 15.9%, similar to that described in previous reports. Hence, IDC may grow slowly while remaining small. | Takeshi Hisa Hiroki Ohkubo Satoshi Shiozawa Hiroki Ishigame Masato Takamatsu Masayuki Furutake Bunsei Nobukawa Koichi Suda | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 14 | Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission显示文摘 | Tetsuya Eto Ken Takase Toshihiro Miyamoto Yuju Ohno Tomohiko Kamimura Koji Nagafuji Yasushi Takamatsu Takanori Teshima Hisashi Gondo Shuichi Taniguchi Koichi Akashi Mine Harada | 2013 | International Journal of Hematology2013，，2： | 2 |
| 15 | Influence of Separated Vortex on Aerodynamic Noise of an Airfoil Blade显示文摘In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade,the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD code.In the case of rear surface separation,the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack angle.The aerodynamic noise level then becomes small according to the vortex scale in the blade chord.When the flow is separated at the leading edge,a separated vortex of low pressure is formed at the vicinity of the trailing edge.The pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the wake.It is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding. | Soichi Sasaki Hajime Takamatsu Masao Tsujino Haruhiro Tsubota Hidechito Hayashi | 2010 | Journal of Thermal Science2010，19，1： | 2 |
| 16 | Enhaneed Protective response and immuno-adjuvant effects of porcine GM CSF on DNA vaccination of npigs Aujeszky's disease virus显示文摘 | Somasundaram C Takamatsu H Andreoni C | 1999 | Vet Immunol Immunopathol1999，70，： | 1 |
| 17 | Thermosensitive suicide vectors for gene replacement in Streptococcus suis显示文摘 | Takamatsu D Osaki M Sekizaki T | 2001 | Plasmid2001，46，2： | 1 |
| 18 | Expression of gapjunction protein connexin 43 in the adult rat cochlea;comparison with counexin 26显示文摘 | Suzuki T Takamatsu T Oyamada M | 2003 | J Histochem Cytochem2003，51，： | 1 |
| 19 | Effect of remifentanil on plasma propofol concentration and bispectral index during propofol anaesthesia 显示文摘 | Yufune S Takamatsu 1 Masui K | 2011 | Br J Anaesth2011，106，2： | 1 |
| 20 | Specific antibodies to moe- sin,a membrane-cytoskeleton linker protein,are frequently detected in patients with acquired aplastie anaemia显示文摘 | Takamatsu H Feng X Chuhjo T | 2007 | Blood2007，109，6： | 1 |
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