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| 1 | Peginterferon and ribavirin treatment for hepatitis C virus infection显示文摘Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. This combination therapy has drastically improved the rate of sustained virological response, specifically in difficult-to-treat patients. Recently, individualized treatment, such as response-guided therapy, is being developed based on host-, HCV- and treatment-related factors. Furthermore, modified regimens with currently available medications, novel modified IFNα and ribavirin or combinations with specifically targeted antiviral therapy for HCV agents, are currently being investigated. The purpose of this review is to address some issues and epoch-making topics in the treatment of chronic HCV infection, and to discuss more optimal and highly individualized therapeutic strategies for HCV-infected patients. | Akihito Tsubota Kiyotaka Fujise Yoshihisa Namiki Norio Tada | 2011 | World Journal of Gastroenterology2011，17，4： | 16 |
| 2 | 干扰素治疗慢性病毒性肝炎的疗效预测显示文摘目前临床用于治疗慢性肝炎的有普通干扰素和聚乙二醇干扰素,影响其抗病毒疗效的因素比较复杂。下面就干扰素治疗慢性乙型肝炎和慢性丙型肝炎疗效预测因素进行综述。 | 梅咏予 高志良 | 2011 | 中华肝脏病杂志2011，19，1： | 9 |
| 3 | The Predictive Value of On-treatment Virological Response for Sustained Virological Response in Patients with Chronic Hepatitis C Receiving a Personalized Treatment Program显示文摘To investigate the effects of individualised treatment with peginterferon alpha-2a(40 kD)plus ribavirin in Chinese patients with CHC.Methods Total of 297 consecutive Chinese patients were enrolled,including 250 nave cases and 47 cases who were previously treated.Treatment duration was determined according to viral genotypes,prior treatment history and viral responses at week 4,12 and 24.Results Totally,235 patients(79.1%)completed treatment and 186(87.3%)achieved SVR.And 219 out of 289(75.8%)patients achieved HCV RNA negative at week 4(RVR)and 259 of 276(93.8%)at week 12.Among the 164 patients with RVR who completed follow-up,158(96.3%)achieved SVR.Patients with RVR had lower baseline viral loads than patients without RVR(P=0.034).The positive predictive value(PPV)of RVR for SVR was 90.7%(OR 2.10 vs.non-RVR,95%CI:0.50-8.7).Similar outcomes were observed among patients with HCV undetectable at week 12.Conclusions Viral suppression by week 4 is associated with a high rate of treatment success in treatment nave and experienced patients receiving individualized CHC therapy. | Ming-hui Li Yao Xie Yao Lu Guo-hua Qiu Lu Zhang Ge Shen Li-wei Zhuang Ju-long Hu Jian-ping Dong Cai-qin Mu Lei-ping Hu Li-jun Chen Xing-hong Li Min Yang Yun-zhong Wu Hui Zhao Shu-jing Song Jun Cheng Dao-zhen Xu | 2013 | 国际感染病学(电子版)2013，2，2： | 2 |
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