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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Changes in rhizosphere populations of selected physiological groups of bacteria related to substitution of specific pairs of chromosomes in spring wheat显示文摘 | Neal J L Larson R I Atkinson T G | 1973 | Plant Soil1973，39，： | 1 |
| 4 | Testing the metals hypothesis in Spokane, Washington显示文摘 | CLAIBORN C S LARSON T SHEPPARD L | 2002 | Environ Health Perspect2002，110，4： | 1 |
| 5 | Fluorodeoxyglucose positron emission tomography as an outcome measure for castrate metastatic prostate cancer treated with antimicrotubule chemotherapy显示文摘 | Morris M J Akhurst T Larson SM | 2005 | Clin- ical cancer research : an official journal of the American Association for Cancer Research2005，11，： | 1 |
| 6 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 7 | SimpleScalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Ernst D | 2002 | IEEE Computer2002，35，2： | 1 |
| 8 | Two-Photon Luminescence Imaging of Cancer Cel s Using Molecularly Targeted Gold Nanorods显示文摘 | Durr NJ Larson T Smith DK | | 0，，04： | 1 |
| 9 | Two-photon luminescence imaging of cancer ceils using molecularly targeted gold nanorods显示文摘 | Durr N J Larson T Smith D K | 2007 | Nano Lett2007，7，4： | 1 |
| 10 | SAUNA--A system for automatic sampling, processing, and analysis of radioactive xenon显示文摘 | RINGBOM A LARSON T AXELSSON A | 2003 | Nuel Instrum Methods A2003，508，： | 1 |
| 11 | Observed microphysical structure of midlevel, mixed-phase ctouds显示文摘 | Fteishauer R P V E Larson T H Vonder Haar | 2002 | J Atmos Sci2002，59，： | 1 |
| 12 | Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructure 显示文摘 | Dong YD Larson I Hanley T | 2006 | Langmuir2006，22，： | 1 |
| 13 | A phase 2 multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma显示文摘 | Fehniger T Larson S Trinkaus K | 2011 | Blood2011，118，19： | 1 |
| 14 | Percutaneous plating of distal tibia1 fractures preliminary results in 21 patients 显示文摘 | Borg T Larson S Lindsjo U | 2004 | Injury2004，35，： | 1 |
| 15 | How do trays and packings stack up显示文摘 | Kister H Z Larson K F Yanagi T | 1994 | Chem Eng Prog1994，90，2： | 1 |
| 16 | Tungsten segregation in a2+Y titanium aluminides 显示文摘 | Larson D J Liu C T Miller M K | 1997 | Intermetallics1997，5，7： | 1 |
| 17 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 18 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses显示文摘 | WEIGHT C J LARSON B T FERGANY A F | 2010 | J Urol2010，183，4： | 1 |
| 19 | Relationships between spa- tial environmental heterogeneity and plant species diversity on a limestone pavement 显示文摘 | LUNDHOLM J T LARSON D W | 2003 | Ecography2003，26，6： | 1 |
| 20 | Identification of mRNAs expressed in tumor infiltrating lymphocytes by a strategy for rapid and high through put screening显示文摘 | Li B Chang T Larson A | 2000 | Gene2000，255，2： | 1 |
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