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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014,5,2: | 5 |
| 2 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996,100,15: | 3 |
| 3 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996,275,20: | 1 |
| 4 | Genome remodelling in a basal-like breast cancer metastasis and xenograft显示文摘 | Ding L Ellis MJ Li S Larson DE | 2010 | Nature2010,464,7291: | 1 |
| 5 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005,182,2: | 1 |
| 6 | A dynamic estimator for tracking the state of a power system显示文摘 | DebsA S Larson R E | 1970 | IEEE Transactions on Power Apparatus arid Systems1970,89,7: | 1 |
| 7 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008,63,6: | 1 |
| 8 | Testing the metals hypothesis in Spokane, Washington显示文摘 | CLAIBORN C S LARSON T SHEPPARD L | 2002 | Environ Health Perspect2002,110,4: | 1 |
| 9 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980,85,: | 1 |
| 10 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006,46,5: | 1 |
| 11 | A survey of thyroidgland scintigraphy显示文摘 | CRAWFORDE S GUARASCI DT LARSON S A | 2009 | J Nucl Med Technol2009,37,3: | 1 |
| 12 | A phase Ⅱ multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma显示文摘 | Fehniger TA Larson S Trinkaus K | 2009 | Blood2009,114,: | 1 |
| 13 | Making sense of loss and benefiting from the experience:Two construals of meaning显示文摘 | Davis C.G Nolen-Hoeksema S Larson J | | 0,,02: | 1 |
| 14 | Binding and insertion of alpha-helical anti-microbial peptides in POPC bilay- ers studied by molecular dynamics simulations 显示文摘 | Kandasamy S K Larson R G | 2004 | Chemistry and physics of lipids2004,132,1: | 1 |
| 15 | Circulating CD31+leukocyte frequency is associated with cardiovascular risk factors显示文摘 | GE Y CHENG S LARSON MG | 2013 | Atherosclerosis2013,229,1: | 1 |
| 16 | Gamma knife radiosurgery in children 显示文摘 | Baumanna S Wara WM Larson DA | 1996 | Pediatr Neurosurg1996,24,: | 1 |
| 17 | Towards multidimensional radiotherapy(MD-CRT):biological imaging and biological conformality显示文摘 | Ling CC Humm J Larson S | 2000 | Int J Radiat Oncol Biol Phys2000,47,3: | 1 |
| 18 | Polycystin-1,STAT6,and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease显示文摘 | Low S H Vasanth S Larson C H | 2006 | Dev Cell2006,10,1: | 1 |
| 19 | Contrasting mode of evolution at a coat color locus in wild and domestic pigs显示文摘 | FANG M LARSON G RIBEIRO H S | 2009 | PloS Genetics2009,5,10: | 1 |
| 20 | Antitumor and antiviral activity of synthetic α- and β-ribonucleosides of certain substituted pyrimidopyrimidines:a new synthetic strategy for exocyclic aminonucleosides显示文摘 | Sanghvi Y S Larson S B Matsumoto S S | 1989 | J Med Chem1989,32,3: | 1 |