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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Systemic inflammation and copd: the framing, ham heart study 显示文摘 | Walter R E Wilk J B Larson M G | 2008 | Chest2008，133，1： | 1 |
| 3 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 4 | A dynamic estimator for tracking the state of a power system显示文摘 | DebsA S Larson R E | 1970 | IEEE Transactions on Power Apparatus arid Systems1970，89，7： | 1 |
| 5 | Processing aspects of the space shuttle orbiter's ceramic reusable surface insu- lation显示文摘 | Banas R P Gzowski E R Larson W L | 1983 | Ceram Eng Sci Proc1983，4，78： | 1 |
| 6 | Helicobaeter pylori infection显示文摘 | Larson JT Skjelbo E Gram LF | 1997 | Lancet1997，349，9055： | 1 |
| 7 | A theory of high-frequency distortion in bipolar transistors显示文摘 | Vaidyanathan Mani Iwamoto Masaya Larson Lawrence E | 2003 | IEEE Trans on Microwave Theory and Techniques2003，51，2： | 1 |
| 8 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 9 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 10 | Nurse workingconditions,organizational climate,and intent to leave in ICUs : aninstrumental variable approach part I显示文摘 | Stone P Mooney-Kane C Larson E | 2007 | Health Serv Hes2007，42，3： | 1 |
| 11 | The rising tide of dementia worldwide显示文摘 | Larson E Langa K | | 0，，9637： | 1 |
| 12 | Sitagliptin,a dipeptidyl peptidase-4 inhibitor,does not affect the pharmaeokinetics of ethinyl estradiol or norethindrone in healthy female subjects显示文摘 | Migoya E Larson P Bergman A et a1 | 2011 | J Clin Pharmacol2011，51，9： | 1 |
| 13 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 14 | SimpleScalar:An Infrastructure for Computer System Modeling显示文摘 | Austin T Larson E Ernst D | 2002 | IEEE Computer2002，35，2： | 1 |
| 15 | Efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive acute myeloid leukemia in first relapse显示文摘 | Sievers E L Larson R A Stadtmauer E A | 2001 | J Clin Oncol2001，，： | 1 |
| 16 | Geological consequences of superplumes显示文摘 | Sheridan R E Larson R L | 1992 | Geology1992，20，5： | 1 |
| 17 | Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide,doxorubicin,vincristine,and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lympho显示文摘 | Karmali R Larson M L Wooldridge J E | | 0，，11： | 1 |
| 18 | Community factors in the development of antibiotic resistance 显示文摘 | Larson E | 2007 | Annu Rev Public Health2007，28，： | 1 |
| 19 | Rebound of five one-dimensionally compressed unsaturated granular soils显示文摘 | STONE J A LARSON W E | 1980 | Soil Science Society of America Journal1980，44，4： | 1 |
| 20 | Observed microphysical structure of midlevel, mixed-phase ctouds显示文摘 | Fteishauer R P V E Larson T H Vonder Haar | 2002 | J Atmos Sci2002，59，： | 1 |
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